Joseph Brama chepụtara usoro extrusion maka mmepụta ọkpọkọ ndu na njedebe narị afọ nke 18.Ọ bụ n'etiti narị afọ nke 19 ka a malitere iji nkà na ụzụ extrusion na-ekpo ọkụ na-agbaze na ụlọ ọrụ plastik.A na-eji ya na mbụ na-emepụta ihe mkpuchi mkpuchi polymer maka wires eletrik.Taa a na-eji nkà na ụzụ na-agbaze ọkụ na-ekpo ọkụ eme ihe ọ bụghị nanị na mmepụta nke ngwaahịa polymer, kamakwa na mmepụta na ngwakọta nke polymers n'onwe ha.Ka ọ dị ugbu a, a na-emepụta ihe karịrị ọkara nke ngwaahịa rọba, gụnyere akpa rọba, mpempe akwụkwọ plastik na ọkpọkọ plastik, site na iji usoro a.
Ka e mesịrị, nkà na ụzụ a ji nwayọọ nwayọọ pụta n'ọhịa ọgwụ ma jiri nwayọọ nwayọọ ghọọ nkà na ụzụ dị mkpa.Ugbu a ndị mmadụ na-eji teknụzụ extrusion na-ekpo ọkụ na-ekpo ọkụ iji kwadebe granules, mbadamba ihe na-adịgide adịgide, transdermal na transmucosal usoro nnyefe ọgwụ wdg. Gịnị mere ndị mmadụ ji ahọrọ nkà na ụzụ a ugbu a?Ihe kpatara ya bụ n'ihi na e jiri ya tụnyere usoro mmepụta omenala n'oge gara aga, nkà na ụzụ extrusion na-ekpo ọkụ nwere uru ndị a:
Melite mgbasa nke ọgwụ na-adịghị mma soluble
Enwere uru dị n'ịkwado usoro mwepụta na-adịgide adịgide
Nkwadebe nke ihe ntọhapụ nke eriri afọ nwere ọnọdụ ziri ezi
Melite mkpakọ ihe na-akpali akpali
A na-eme usoro slicing n'otu nzọụkwụ
Mepee ụzọ ọhụrụ maka nkwadebe nke micropellets
N'ime ha, cellulose ether na-arụ ọrụ dị mkpa na usoro a, ka anyị leba anya na ntinye nke cellulose ether anyị na ya!
Eji ethyl cellulose mee ihe
Ethyl cellulose bụ ụdị hydrophobic ether cellulose.Na ọgwụ ubi, a na-eji ya ugbu a na microencapsulation nke nọ n'ọrụ bekee, mgbaze na extrusion granulation, mbadamba piping na dị ka mkpuchi nke achịkwa ntọhapụ mbadamba na beads.Ethyl cellulose nwere ike ịbawanye ibu arọ dị iche iche.Okpomọkụ mgbanwe iko ya bụ 129-133 Celsius, ebe mgbaze kristal ya na-ebelata ogo Celsius 180.Ethyl cellulose bụ ezigbo nhọrọ maka extrusion n'ihi na ọ na-egosipụta thermoplastic Njirimara n'elu iko mgbanwe okpomọkụ na n'okpuru ya nbibi okpomọkụ.
Iji wedata okpomọkụ mgbanwe iko nke polymers, usoro a na-emekarị bụ ịgbakwunye ihe ndị na-emepụta ihe, ya mere enwere ike ịhazi ya na obere okpomọkụ.Ụfọdụ ọgwụ nwere ike ime dị ka ndị na-emepụta ihe n'onwe ha, n'ihi ya, ọ dịghị mkpa itinyeghachi plasticizers n'oge usoro nhazi ọgwụ.Dịka ọmụmaatụ, achọpụtara na ihe nkiri extruded nwere ibuprofen na ethyl cellulose nwere okpomọkụ mgbanwe iko dị ala karịa ihe nkiri nwere nanị ethyl cellulose.Enwere ike ịme ihe nkiri ndị a n'ime ụlọ nyocha na ndị na-arụkọ ọrụ ejima-screw extruders.Ndị nchọpụta ahụ gbasakwara ya ka ọ bụrụ ntụ ntụ wee mee nyocha nke okpomọkụ.Ọ tụgharịrị na ịba ụba ibuprofen nwere ike belata okpomọkụ mgbanwe iko.
Nnwale ọzọ bụ ịgbakwunye ihe mgbakwunye hydrophilic, hypromellose, na xanthan gum na ethylcellulose na ibuprofen micromatrices.E kwubiri na micromatrix mepụtara site na usoro extrusion na-ekpo ọkụ na-agbaze nwere usoro ntinye ọgwụ mgbe niile karịa ngwaahịa ndị a na-ere ahịa.Ndị nyocha ahụ mepụtara micromatrix ahụ site na iji nhazi ụlọ nyocha na-agbanwe agbanwe na ihe eji ekpuchi ejima nwere anwụ cylindrical 3-mm.Ibé akwụkwọ ndị e ji aka kpụọ bụ 2mm n'ogologo.
A na-eji hypromellose mee ihe
Hydroxypropyl methylcellulose bụ ether cellulose hydrophilic nke na-adaba n'ime ngwọta colloidal doro anya ma ọ bụ dịtụ ntakịrị na mmiri oyi.Ihe ngwọta mmiri nwere ọrụ elu, nghọta dị elu na arụmọrụ kwụsiri ike.Solubility dị iche na viscosity.Na ala viscosity, ka ukwuu solubility.Njirimara nke hydroxypropyl methylcellulose nwere nkọwa dị iche iche dị iche iche, na mgbaze ya na mmiri adịghị emetụta uru pH.
Na ụlọ ọrụ na-emepụta ọgwụ, a na-ejikarị ya na matrix ntọhapụ a na-achịkwa, nhazi mkpuchi mbadamba, nrapado granulation, wdg. The iko mgbanwe okpomọkụ nke hydroxypropyl methylcellulose bụ 160-210 degrees Celsius, nke pụtara na ọ bụrụ na ọ na-adabere na ndị ọzọ na-anọchi, ya mmebi okpomọkụ. gafere 250 Celsius.N'ihi okpomọkụ mgbanwe iko ya dị elu yana ọnọdụ okpomọkụ dị ala, a naghị eji ya eme ihe na nkà na ụzụ extrusion ọkụ ọkụ.Iji gbasaa ohere iji ya mee ihe, otu ụzọ bụ ijikọta ọnụ ọgụgụ buru ibu nke plasticizer na usoro nhazi dị ka ndị ọkà mmụta abụọ ahụ kwuru, na-eji usoro extrusion matrix nke ịdị arọ nke plasticizer dịkarịa ala 30%.
Ethylcellulose na hydroxypropylmethylcellulose nwere ike jikọta ya n'ụzọ pụrụ iche na nnyefe ọgwụ.Otu n'ime ụdị ọgwụgwọ a bụ iji ethylcellulose dị ka tube dị n'èzí, wee dozie ọkwa hypromellose A iche.Isi cellulose isi.
A na-emepụta tubing ethylcellulose site na iji extrusion na-ekpo ọkụ na-agbaze na igwe na-agbanwe agbanwe na ụlọ nyocha na-etinye mgbanaka ígwè die tube, nke a na-eji aka ya eme ya site na ikpokọta mgbakọ ahụ ruo mgbe ọ gbazee, na-esote homogenization.A na-eji aka tinye ihe ndị bụ isi n'ime pipeline.Ebumnuche nke ọmụmụ ihe a bụ ikpochapụ mmetụta nke popping nke na-eme mgbe ụfọdụ na mbadamba hydroxypropyl methylcellulose matrix.Ndị nyocha ahụ ahụghị ihe dị iche na ọnụego ntọhapụ maka hydroxypropyl methylcellulose nke otu viscosity, Otú ọ dị, dochie hydroxypropyl methylcellulose na methylcellulose mere ka ọnụego mwepụta ngwa ngwa.
Outlook
Ọ bụ ezie na ịgbaze ọkụ na-ekpo ọkụ bụ nkà na ụzụ ọhụrụ dị na ụlọ ọrụ ọgwụ, ọ dọtara ọtụtụ nlebara anya ma jiri ya mee ka mmepụta nke ọtụtụ ụdị usoro onunu ogwu dị iche iche na usoro.Nkà na ụzụ extrusion na-ekpo ọkụ na-agbaze aghọwo nkà na ụzụ na-eduga maka ịkwadebe mgbasa siri ike na mba ọzọ.N'ihi na ụkpụrụ teknụzụ ya yiri ọtụtụ ụzọ nkwadebe, yana etinyere ya na ụlọ ọrụ ndị ọzọ ruo ọtụtụ afọ ma chịkọta ọtụtụ ahụmahụ, ọ nwere atụmanya mmepe sara mbara.Site na omimi nke nyocha, a kwenyere na a ga-abawanye ngwa ngwa ya.N'otu oge ahụ, nkà na ụzụ extrusion na-ekpo ọkụ na-ekpo ọkụ na-enwe obere kọntaktị na ọgwụ ọjọọ na ọkwa dị elu nke akpaaka.Mgbe mgbanwe na ụlọ ọrụ ọgwụ, a kwenyere na mgbanwe GMP ya ga-adị ngwa ngwa.
Oge nzipu: Dec-16-2022