IHydroxypropyl methylcellulose ukuncipha kobunzima

Intshayelelo

IHydroxypropyl methylcellulose (HPMC) sisixhobo sepolymeric esisetyenziswa ngokubanzi kushishino lokutya, amayeza, kunye nezokuthambisa.Yipolymer enyibilikayo emanzini, engekho i-ionic, kunye ne-biodegradable evela kwi-cellulose.I-HPMC isetyenziswe iminyaka emininzi njenge-arhente yokutyebisa, i-emulsifier, i-stabilizer, kunye ne-gelling agent kwiimveliso zokutya ezahlukeneyo.Kwiminyaka yakutshanje, kufunyenwe ukuba izicelo ezinokubakho ekulahlekeni kobunzima.

Indlela yokwenza

I-HPMC yipolima ye-hydrophilic ekwazi ukufunxa amanzi kwaye idumbe ukwenza ijeli.Esi sakhiwo esifana nejeli sicingelwa ukuba sinoxanduva lokukwazi ukunciphisa ukutya kunye nokukhuthaza ukuhlutha.Kukholelwa ukuba i-gel-like structure ye-HPMC yenza umqobo womzimba esiswini, onciphisa ukufunxa kokutya kunye nokwandisa imvakalelo yokuhlutha.Ukongeza, i-HPMC icingelwa ukunciphisa ukufunxwa kwamafutha kunye ne-carbohydrates, enokukhokelela ekulahlekeni kobunzima.

Ubungqina beklinikhi

Kukho izifundo ezininzi zeklinikhi eziye zavavanya iziphumo ze-HPMC ekulahlekeni kobunzima.Kuphononongo olungahleliwe, oluyimfama oluphindwe kabini, olulawulwa yi-placebo, izifundo zanikwa i-HPMC okanye i-placebo kwiiveki ezisibhozo.Ekupheleni kophononongo, izifundo ezazithathe i-HPMC zilahlekelwe kakhulu ubunzima kunabo bathathe indawo ye-placebo.Kwesinye isifundo, izifundo zanikwa i-HPMC okanye i-placebo kwiiveki ze-12.Ekupheleni kophononongo, izifundo ezazithathe i-HPMC zilahlekelwe kakhulu ubunzima kunabo bathathe indawo ye-placebo.

Ukongeza kwezi zifundo, kukho ezinye izifundo ezininzi eziye zavavanya iziphumo ze-HPMC ekulahlekeni kobunzima.Kuphononongo olungahleliwe, oluyimfama oluphindwe kabini, olulawulwa yi-placebo, izifundo zanikwa i-HPMC okanye i-placebo kwiiveki ezisibhozo.Ekupheleni kophononongo, izifundo ezazithathe i-HPMC zilahlekelwe kakhulu ubunzima kunabo bathathe indawo ye-placebo.

Ukhuseleko

I-HPMC ngokuqhelekileyo ithathwa njengekhuselekile ukuba isetyenziswe ngabantu.Ngokuqhelekileyo inyamezeleke kakuhle kwaye ineziphumo ebezingalindelekanga ezimbalwa.Ezona ziphumo bezingalindelekanga zixhaphakileyo ezixeliweyo kukuphazamiseka kancinci kwesisu, okufana nesicaphucaphu, ukuhlanza, kunye norhudo.Ukongeza, i-HPMC inokunxibelelana namayeza athile, ngoko ke kubalulekile ukubonisana nomboneleli wezempilo phambi kokuthatha i-HPMC.

Ukuqukumbela

IHydroxypropyl methylcellulose (HPMC) sisixhobo sepolymeric esisetyenziswa ngokubanzi kushishino lokutya, amayeza, kunye nezokuthambisa.Kufunyaniswe ukuba kunezicelo ezinokubakho ekulahlekeni kobunzima, njengoko kukholelwa ukuba yenze umqobo womzimba esiswini kunye nokunciphisa ukufunxa kwamafutha kunye neecarbohydrates.Izifundo ezininzi zeklinikhi ziye zavavanya iziphumo ze-HPMC ekulahlekeni kobunzima, kwaye iziphumo bezithembisa.I-HPMC ngokuqhelekileyo ithathwa njengekhuselekile ukuba isetyenziswe ngabantu, nangona inokunxibelelana namayeza athile.