O mea fa'aoga masani ole tu'u gutu malō

O sauniuniga mautu o loʻo faʻasalalau faʻasalalau ma sili ona faʻaaogaina fomu i le maketi, ma e masani ona aofia ai ni mea autu se lua ma mea faʻaoga.Excipients, e taʻua foi o mea faʻapitoa, e faʻatatau i le faaupuga lautele mo mea faʻaopoopo uma i sauniuniga faʻamalosi sei vagana ai le vailaʻau autu.E tusa ai ma meatotino eseese ma galuega a mea faʻapitoa, o mea faʻapitoa o sauniuniga faʻamalosi e masani ona vaevaeina i: faʻatumu, faʻapipiʻi, faʻamavae, lubricants, faʻasaʻo faʻatonu, ma o nisi taimi e mafai ona faʻaopoopoina mea faʻalanu ma mea manogi e tusa ai ma manaʻoga o le sauniuniga. e faʻaleleia Pe fetuutuunai foliga ma le tofo o le faʻavae.
O mea e faʻaogaina i sauniuniga malosi e tatau ona fetaui ma manaʻoga mo le faʻaaogaina o vailaʻau, ma ia iai uiga nei: ①E tatau ona maualuga le mautu o vailaʻau ma e leai ni gaioiga faʻaletino ma vailaʻau faʻatasi ma le vailaʻau autu;②E le tatau ona aʻafia ai le togafitiga faʻamaʻi ma le faʻamautuina o mea o le vailaʻau autu;③Leai se afaina i le tino o le tagata E afaina, lima oona, leai ni mea leaga.
1. Fa'atumu (mea manifinifi)
Ona o le maualalo o le fua o le vailaʻau autu, o le fua o nisi vailaʻau o nisi taimi e naʻo ni nai milligrams pe itiiti, lea e le faʻaogaina i le faʻatulagaina o papa poʻo le faʻatonuga o falemaʻi.O le mea lea, pe a oʻo i lalo ole 50mg le vailaʻau autu, e manaʻomia le faʻaopoopoina o se vailaʻau faʻatumu, lea e taʻua o le diluent.
O se mea e fa'atumu lelei e tatau ona fa'aogaina fa'aletino ma kemikolo ma e le a'afia ai le bioavailability o le vaega malosi ole vaila'au.O mea fa'atumu e masani ona fa'aaogaina e aofia ai: ① Masoa, e aofia ai masoa saito, masoa sana, ma pateta pateta, lea e masani ona fa'aaogaina ai le masoa sana;mautu i le natura, maualalo i le hygroscopicity, ae le lelei i le compressibility;② Lactose, sili ona lelei i meatotino ma compressible, suavai lelei;③ sucrose, e malosi hygroscopicity;④ masoa pregelatinized, e lauiloa foi o le masoa compressible, e lelei le compressibility, fluidity ma le tagata lava lubricity;⑤ microcrystalline cellulose, e taʻua o le MCC, e malosi le mafai ona fusifusia ma lelei le faʻamalosi;ua ta'ua o le “fa'amau fa'amago”;⑥Mannitol, faʻatusatusa i mea faʻatumu o loʻo i luga, e sili atu le taugata, ma e masani ona faʻaaogaina i papamaʻa lamu, lea e iai foi se tofo maʻaleʻale;⑦Masima inorganic, e masani lava e aofia ai le calcium sulfate, calcium phosphate, calcium carbonate, ma isi, faʻatasi ai ma mea faʻaletino ma vailaʻau.
2. Su'e susu ma fa'apipi'i
O mea fa'asusu ma mea fa'apipi'i o mea fa'aopoopo e fa'aopoopo i le taimi o le fa'aputuga.O le susū lava ia e le o se viscous, ae o se vai e faʻaosofia ai le viscosity o mea e ala i le susu o mea.O mea fa'asusu masani e fa'aaogaina e aofia ai le vai fa'amama ma le ethanol, ma o vai fa'amama o le filifiliga muamua lea.
O mea fa'apipi'i o lo'o fa'atatau i mea fa'aopoopo e fa'alagolago i lo latou lava viscosity e maua ai mea e le viscous po'o le le lava o mea viscous ma le viscosity talafeagai.O mea fa'apipi'i masani e fa'aaogaina e aofia ai: ① Starch slurry, o se tasi lea o mea fa'apipi'i e masani ona fa'aaogaina, e taugofie, ma e lelei le fa'atinoga, ma o le fa'aoga masani e 8% -15%;②Methylcellulose, e taʻua o le MC, e lelei le solubility vai;③Hydroxypropylcellulose, e taʻua o le HPC, e mafai ona faʻaaogaina e avea o se paʻu faʻapipiʻi tuusaʻo;④Hydroxypropylmethylcellulose, e taʻua o le HPMC, o mea e mafai ona solu i le vai malulu;⑤Carboxymethylcellulose sodium, e taʻua o le CMC-Na, talafeagai mo fualaau faasaina ma le le lelei compressibility;⑥Ethylcellulose, e taʻua o le EC, o le meafaitino e le mafai ona faʻafefe i le vai, ae soluble i le ethanol;⑦Povidone, e taʻua o le PVP, o mea e matuaʻi hygroscopic, soluble i le vai ma le ethanol;⑧E le gata i lea, o loʻo i ai polyethylene glycol (e taʻua o le PEG), Mea e pei o gelatin.
3. Fa'aleaga
O mea fa'aleagaina e fa'atatau i mea fa'aoga e fa'aolaina ai le vave malepe o papa i ni vaega laiti i totonu ole sua o le manava.Se'i vagana ai fualaau tuugutu e iai mana'oga fa'apitoa e pei o papa'a fa'asa'o, fa'atonu-fa'asa'o, ma papa'a lamu, e masani ona mana'omia le fa'aopoopoina o mea fa'apalapala.O mea fa'ama'i e masani ona fa'aaogaina o: ① masoa mago, talafeagai mo vaila'au e le mafai ona solu po'o sina solu;② carboxymethyl starch sodium, e taʻua o le CMS-Na, o lenei mea o se faʻamaʻi maualuga-lelei;③ hydroxypropyl cellulose maualalo-sui, e taʻua o le L -HPC, lea e mafai ona fulafula vave pe a uma ona faʻafefe vai;④Cross-linked methyl cellulose sodium, e taʻua o CCMC-Na;e fufula muamua le mea i le vai ona solo lea, ma e le mafai ona solu i le ethanol;O le fa'aletonu o le malosi o le hygroscopicity ma e masani ona fa'aaogaina i le fa'aputuina o papa effervescent po'o papa'a lamu;⑥Effervescent disintegrants e masani ona aofia ai le paluga o le sodium bicarbonate ma le citric acid, ma le citric acid, fumaric acid, ma le sodium carbonate e mafai foi ona faʻaaogaina, Patassium Carbonate ma Patassium Bicarbonate ma isi.
4. Lubricant
Lubricants e mafai ona vaevaeina lautele i ni vaega se tolu, e aofia ai glidants, anti-sticking agents, ma lubricants i se uiga vaapiapi.① Glidant: o lana galuega autu o le faʻaitiitia o feteʻenaʻiga i le va o vaega, faʻaleleia le suavai o le paʻu, ma fesoasoani e faʻaitiitia le eseesega i le mamafa o le laulau;② anti-pipii sui: o lana galuega autu o le puipuia o le pipii i le taimi o le faʻapipiʻiina o laupepa, Ina ia faʻamautinoa le sologa lelei o le faʻaogaina o laupepa, e mafai foi ona faʻaleleia foliga o papa;③ lubricant chivalrous: faʻaitiitia le feteʻenaʻiga i le va o mea ma le puipui puipui, ina ia mautinoa le faʻagaioiina o le faʻapipiʻiina ma le tuleia.O lubricants masani e faʻaaogaina (i se uiga lautele) e aofia ai le talc paʻu, magnesium stearate (MS), micronized silica gel, polyethylene glycols, sodium lauryl sulfate, suauʻu fualaau faisua, ma isi.
5. Fa'asa'oloto modulator
Faʻasaʻo faʻatonuga i totonu o laulau tuʻu gutu e talafeagai mo le faʻatonutonuina o le saoasaoa ma le tikeri o le tuʻuina atu o vailaʻau i le tuʻuina atu o le tuʻuina atu o sauniuniga, ina ia mautinoa o loʻo tuʻuina atu le vailaʻau i le nofoaga o maʻi i se saoasaoa patino ma faʻatumauina se faʻatonuga i totonu o masini poʻo sua o le tino. , e maua ai le fa'amoemoega fa'afoma'i a'afiaga ma fa'aitiitia ai a'afiaga oona ma itu.E masani ona fa'aaogaina fa'atonuga fa'asa'oloto e masani ona vaevaeina i le matrix type, polymer fa'asa'oloto fa'asolo fa'asolo ata ma mafiafia.
(1) Matrix-ituaiga tatala modulator
①Hydrophilic gel skeleton mea: e fula pe a faʻaalia i le vai e fai ai se pa puipui e pulea ai le faʻamalolo o fualaau, e masani ona faʻaaogaina o le methyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, povidone, carbomer, alginic acid Salt, chitosan, ma isi.
② Mea auivi e le mafai ona solu: O mea auivi e le mafai ona solu e faasino ile polymer mole mole maualuga e le mafai ona solu ile vai pe itiiti foi le soluble vai.E masani ona faʻaaogaina o le ethyl cellulose, polyethylene, five-toxic polyethylene, polymethacrylic acid, ethylene-vinyl acetate copolymer, silicone rubber, etc.
③ Bioerodible framework material: E masani ona faʻaogaina mea faʻavae bioerodible e aofia ai gaʻo manu, suauʻu fualaau faisua, beeswax, stearyl alcohol, carnauba wax, glyceryl monostearate, ma isi.
(2) Fa'apipi'i fa'asa'oloto fa'aliliu
① O mea faʻapolopolo e le mafai ona faʻaaogaina: mea masani e le mafai ona faʻaaogaina e pei ole EC.
②Enteric polymer mea: mea masani enteric polymer mea masani e aofia ai resini acrylic, L-ituaiga ma S-ituaiga, hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate phthalate (CAP), hydroxypropylmethylcellulose phthalate (HPMCP), ma isi. mea i luga i le sua intestinal, ma solo i vaega patino e faia se matafaioi.
6. Isi mea fa'aoga
I le faaopoopo atu i mea faʻaoga masani o loʻo taʻua i luga, o isi mea faʻapitoa e faʻaopoopoina i nisi taimi ina ia sili atu ona fetaui ma manaʻoga o le faʻatonutonuina o vailaʻau, faʻaleleia le iloa o vailaʻau poʻo le faʻaleleia atili o le tausisia.Mo se faʻataʻitaʻiga, valivali, faʻamalo ma faʻamalieina.
①Sui valivali: O le faʻamoemoega autu o le faʻaopoopoina o mea nei o le faʻaleleia o foliga o le laulau ma faʻafaigofie ona iloa ma iloa.O lanu e masani ona faʻaaogaina e tatau ona fetaui ma faʻamatalaga tau vailaʻau, ma o le aofaʻi faʻaopoopo e le tatau ona sili atu i le 0.05%.
②Aromatics ma suamalie: O le faʻamoemoe autu o mea manogi ma suamalie o le faʻaleleia lea o le tofo o vailaʻau, e pei o papaʻa lamu ma laulau faʻamaʻi tautala.O mea manogi e masani ona fa'aaogaina e masani ona aofia ai essences, suau'u manogi eseese, ma isi;suamalie e masani ona faʻaaogaina e aofia ai sucrose, aspartame, ma isi.