ethula
IHydroxypropyl methylcellulose (HPMC) i-nonionic cellulose ether esetshenziswa kakhulu ezimbonini ezahlukahlukene ngenxa yezindawo zayo ezinhle kakhulu njengokuncibilika kwamanzi, impahla yokwakha ifilimu, nokunamathela.Ikhono layo lokushintsha i-viscosity liyenza ilungele ukusetshenziswa okuningi, okuhlanganisa ukudla, imithi kanye nopende.I-HPMC isuselwa ku-cellulose ye-polymer yemvelo, e-glycosylated ukuze yakhe isakhiwo senethiwekhi ye-cellulose-oxygen.Izakhiwo kanye ne-viscosity ye-HPMC kuncike ezicini ezifana nesisindo samangqamuzana, izinga lokushintsha, ukugxila, uhlobo lwe-solvent, i-pH, izinga lokushisa namandla e-ionic.
Kulesi sihloko, sizoxoxa ngezinto ezithonya i-HPMC viscosity kanye nezindlela zabo.
isisindo samangqamuzana
Isisindo samangqamuzana e-HPMC ikakhulukazi sinquma i-viscosity yayo.Ngokusobala, ukuphakama kwesisindo samangqamuzana, kuba yilapho kuba ne-viscous eyengeziwe.Isisindo samangqamuzana e-HPMC sisuka ku-10^3 siye ku-10^6 Da.Njengoba isisindo samangqamuzana sikhula, inani lokubopha phakathi kwamaketanga e-HPMC nalo liyakhula, okuholela ekwandeni kwe-viscosity.
Izinga lokushintsha
Izinga lokushintshwa (DS) le-HPMC linquma inani le-hydroxypropyl namaqembu e-methyl ngesakhiwo sayo.I-HPMC ene-DS ephakeme i-hydrophobic kakhulu futhi ayincibiliki emanzini kune-HPMC ene-DS ephansi.Izinga lokushintsha lithinta ukunyibilika kwe-HPMC emanzini, okubuye kuthinte ikhono layo lokwakha amanethiwekhi abambene futhi andise i-viscosity.
gxila
Ukugxila kungenye yezinto ezibaluleke kakhulu ezithinta i-viscosity ye-HPMC.Ngokuvamile, i-viscosity yezixazululo ze-HPMC iyanda ngokugxila okukhulayo.Lokhu kuziphatha kubangelwe ekuboshweni kwamaketanga e-HPMC ezindaweni eziphakeme kakhulu.
Uhlobo lwe-solvent
Uhlobo lwe-solvent ludlala indima ebalulekile ku-viscosity ye-HPMC.Kwezinye izimo, i-HPMC ine-viscosity ephakeme emanzini kunakwamanye ama-organic solvents.Isizathu singase sibe ngenxa yokusebenzisana okuhlukile phakathi kwe-solvent kanye nama-molecule e-HPMC.
pH
I-pH yesisombululo ingathinta kakhulu i-viscosity ye-HPMC.Ku-pH ene-acidic, i-HPMC ingenza ibhondi ye-hydrogen ne-solvent, ibangele ukwanda kwe-viscosity.Ngaphezu kwalokho, i-pH ithinta izinga le-ionization ye-hydroxypropyl namaqembu e-methyl, okubuye kuthinte ukusebenzisana kwe-electrostatic kanye ne-hydrophobic phakathi kwamaketanga e-HPMC.
izinga lokushisa
Izinga lokushisa liphinde libe nomthelela ku-viscosity ye-HPMC.Emazingeni okushisa aphezulu, ama-molecule e-HPMC anokuhamba okuphezulu, okuholela ekunciphiseni ukusebenzisana kwama-intermolecular.Lokhu kuziphatha ngokuvamile kubangela ukuncipha kwe-viscosity yesixazululo.Isimo esiphambene sibhekwa emazingeni okushisa aphansi.Ngenxa yokuqina kwama-molecule e-HPMC, i-viscosity yesisombululo iyanda ngokuncipha kwezinga lokushisa.
amandla e-ionic
Amandla e-Ionic angenye into ethinta i-viscosity ye-HPMC.Le parameter ibhekisela ekugxilweni kwama-ion esixazululweni.Usawoti onjenge-sodium chloride ungathinta kakhulu i-viscosity ye-HPMC ngokudala izinguquko esimweni se-ionization samaqembu e-hydroxypropyl kanye ne-methyl.Lolu shintsho lushintsha ukusebenzisana phakathi kwama-molecule e-HPMC, ngaleyo ndlela kuthinte i-viscosity yesisombululo.
Ekuphetheni
I-viscosity ye-HPMC ithintwa izici eziningi, okuhlanganisa isisindo samangqamuzana, izinga lokushintshwa, ukugxila, uhlobo lwe-solvent, i-pH, izinga lokushisa namandla e-ionic.Lapho wenza imikhiqizo equkethe i-HPMC, kubalulekile ukucabangela zonke lezi zici ukuze uqinisekise ukuthi i-viscosity oyifunayo iyafinyelelwa.Ukwenziwa kahle kwalezi zici kungaholela ekwakhekeni komkhiqizo osebenzayo futhi ozinzile ohlangabezana nenhloso yawo.
Isikhathi sokuthumela: Sep-12-2023