Kodi ndi zinthu ziti zomwe zimakhudza kukhuthala kwa HPMC?

dziwitsani

Hydroxypropyl methylcellulose (HPMC) ndi nonionic cellulose ether yomwe imagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana chifukwa cha zinthu zake zabwino kwambiri monga kusungunuka kwamadzi, kupanga mafilimu, ndi kumamatira.Kuthekera kwake kusintha mamasukidwe akayendedwe kumapangitsa kukhala koyenera pazinthu zambiri, kuphatikiza chakudya, mankhwala ndi utoto.HPMC limachokera ku chilengedwe polima mapadi, amene glycosylated kupanga mapadi-oxygen network dongosolo.The katundu ndi mamasukidwe akayendedwe a HPMC zimadalira zinthu monga molecular kulemera, mlingo wa m'malo, ndende, zosungunulira mtundu, pH, kutentha ndi ionic mphamvu.

M'nkhaniyi, tikambirana zinthu zomwe zimakhudza kukhuthala kwa HPMC ndi njira zawo.

kulemera kwa maselo

Kulemera kwa maselo a HPMC makamaka kumatsimikizira kukhuthala kwake.Mwachiwonekere, kulemera kwa mamolekyu kukukwera kwambiri, kumakhala kowoneka bwino kwambiri.Kulemera kwa mamolekyulu a HPMC kumayambira 10^3 mpaka 10^6 Da.Pamene kulemera kwa maselo kumawonjezeka, chiwerengero cha zomangira pakati pa maunyolo a HPMC chimawonjezekanso, zomwe zimapangitsa kuwonjezeka kwa mamasukidwe akayendedwe.

Digiri ya m'malo

Digiri ya m'malo (DS) ya HPMC imatsimikizira kuchuluka kwa magulu a hydroxypropyl ndi methyl pamapangidwe ake.HPMC yokhala ndi DS yapamwamba imakhala ya hydrophobic komanso yosasungunuka m'madzi kuposa HPMC yokhala ndi DS yotsika.Mlingo wa m'malo amakhudza kusungunuka kwa HPMC m'madzi, zomwe zimakhudzanso kuthekera kwake kupanga maukonde omangika ndikuwonjezera kukhuthala.

kuganizira

Kukhazikika ndi chimodzi mwazinthu zofunika kwambiri zomwe zimakhudza kukhuthala kwa HPMC.Nthawi zambiri, kukhuthala kwa mayankho a HPMC kumachulukirachulukira.Khalidweli limabwera chifukwa chomangika kwa maunyolo a HPMC pamalo okwera kwambiri.

Mtundu wa zosungunulira

Mtundu wa zosungunulira umagwira ntchito yofunika kwambiri pakukhazikika kwa HPMC.Nthawi zina, HPMC imakhala ndi mamasukidwe apamwamba m'madzi kuposa m'madzi ena osungunulira.Chifukwa chikhoza kukhala chifukwa cha kuyanjana kosiyana pakati pa zosungunulira ndi mamolekyu a HPMC.

pH

PH ya yankho imatha kukhudza kwambiri kukhuthala kwa HPMC.Pa acidic pH, HPMC imatha kupanga zomangira za haidrojeni ndi zosungunulira, zomwe zimapangitsa kuwonjezereka kwa mamasukidwe.Kuphatikiza apo, pH imakhudzanso kuchuluka kwa ionization ya hydroxypropyl ndi magulu a methyl, omwe amakhudzanso kuyanjana kwa electrostatic ndi hydrophobic pakati pa maunyolo a HPMC.

kutentha

Kutentha kumakhudzanso kukhuthala kwa HPMC.Pakutentha kwambiri, mamolekyu a HPMC amakhala ndi kuyenda kwakukulu, zomwe zimapangitsa kuti pakhale kuchepetsedwa kwa ma intermolecular.Khalidwe limeneli nthawi zambiri limabweretsa kuchepa kwa kukhuthala kwa yankho.Chotsutsanacho chimawonedwa pa kutentha kochepa.Chifukwa cha kuuma kwa mamolekyu a HPMC, kukhuthala kwa yankho kumawonjezeka ndi kuchepa kwa kutentha.

mphamvu ya ionic

Mphamvu ya Ionic ndi chinthu china chomwe chimakhudza kukhuthala kwa HPMC.Izi parameter zikutanthauza ndende ya ayoni mu yankho.Mchere monga sodium chloride ukhoza kukhudza kwambiri kukhuthala kwa HPMC poyambitsa kusintha kwa ionization yamagulu a hydroxypropyl ndi methyl.Kusintha kumeneku kumasintha kuyanjana pakati pa mamolekyu a HPMC, motero kumakhudza kukhuthala kwa yankho.

Pomaliza

The mamasukidwe akayendedwe a HPMC amakhudzidwa ndi zinthu zambiri, kuphatikizapo kulemera kwa maselo, mlingo wa m'malo, ndende, zosungunulira mtundu, pH, kutentha ndi ionic mphamvu.Popanga zinthu zomwe zili ndi HPMC, ndikofunikira kuganizira zonsezi kuti muwonetsetse kuti kukhuthala komwe mukufuna kukwaniritsidwa.Kukhathamiritsa koyenera kwa zinthu izi kungapangitse kuti pakhale mankhwala othandiza komanso okhazikika omwe amakwaniritsa cholinga chake.