ukwazisa
I-Hydroxypropyl methylcellulose (HPMC) yi-ether ye-cellulose ye-nonionic esetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeempawu zayo ezintle ezifana nokunyibilika kwamanzi, ipropati yokwenza ifilimu, kunye nokubambelela.Ukukwazi kwayo ukutshintsha i-viscosity kwenza ukuba ilungele izicelo ezininzi, kubandakanya ukutya, amayeza kunye neepeyinti.I-HPMC ithathwe kwi-cellulose ye-polymer yendalo, efakwe kwi-glycosylated ukwenza i-cellulose-oxygen network structure.Iimpawu kunye ne-viscosity ye-HPMC ixhomekeke kwizinto ezifana nobunzima be-molecular, i-degree of substitution, i-concentration, uhlobo lwe-solvent, i-pH, ubushushu kunye namandla e-ionic.
Kweli nqaku, siza kuxubusha izinto ezichaphazela i-HPMC viscosity kunye neendlela zabo.
ubunzima bemolekyuli
Ubunzima bemolekyuli ye-HPMC ikakhulu bumisela i-viscosity yayo.Ngokucacileyo, okukhona buphezulu ubunzima bemolekyuli, kokukhona buba ne-viscous.Ubunzima be-molecular ye-HPMC buvela kwi-10 ^ 3 ukuya kwi-10 ^ 6 Da.Njengoko ubunzima bemolekyuli bukhula, inani leentanglement phakathi kwamatyathanga e-HPMC nawo ayanda, okukhokelela ekunyukeni kwe-viscosity.
Isidanga sokutshintsha
Umgangatho wokutshintshwa (DS) we-HPMC umisela inani le-hydroxypropyl kunye namaqela e-methyl kubume bayo.I-HPMC ene-DS ephezulu i-hydrophobic kwaye i-soluble encinci emanzini kune-HPMC ene-DS ephantsi.Iqondo lokutshintshwa kuchaphazela ukunyibilika kwe-HPMC emanzini, nto leyo echaphazela ukukwazi kwayo ukwenza uthungelwano olubambekayo kunye nokwandisa i-viscosity.
ingqalelo
Ukugxila yenye yezona zinto zibalulekileyo ezichaphazela i-HPMC viscosity.Ngokubanzi, i-viscosity yezisombululo ze-HPMC iyanda ngokuxinana okukhulayo.Oku kuziphatha kubalelwa ekubopheleleni kwamatyathanga e-HPMC kwiindawo eziphezulu.
Uhlobo lokunyibilikisa
Uhlobo lwesinyibilikisi ludlala indima ebalulekileyo kwi-viscosity ye-HPMC.Kwezinye iimeko, i-HPMC ine-viscosity ephezulu emanzini kunezinye izinyibilikisi eziphilayo.Isizathu sisenokuba ngenxa yentsebenziswano eyahlukileyo phakathi kwe-solvent kunye ne-HPMC molekyuli.
pH
I-pH yesisombululo inokuchaphazela kakhulu i-viscosity ye-HPMC.Kwi-acidic pH, i-HPMC inokwenza iibhondi ze-hydrogen kunye ne-solvent, ebangela ukwanda kwe-viscosity.Ngaphaya koko, i-pH ichaphazela iqondo le-ionization ye-hydroxypropyl kunye namaqela e-methyl, ethi yona ichaphazele unxibelelwano lwe-electrostatic kunye ne-hydrophobic phakathi kwamatyathanga e-HPMC.
ubushushu
Ubushushu bukwanefuthe kwi-viscosity ye-HPMC.Kubushushu obuphezulu, iimolekyuli ze-HPMC zinokuhamba okuphezulu, okukhokelela ekunciphiseni ukusebenzisana kwe-intermolecular.Oku kuziphatha ngokuqhelekileyo kubangela ukuhla kwe-viscosity yesisombululo.Imeko echaseneyo ibonwa kumaqondo aphantsi.Ngenxa yokuqina kweemolekyuli ze-HPMC, i-viscosity yesisombululo iyanda ngokuhla kweqondo lokushisa.
amandla e-ionic
Amandla e-Ionic yenye into echaphazela i-viscosity ye-HPMC.Le parameter ibhekiselele kuxinzelelo lwee-ion kwisisombululo.Iityuwa ezifana ne-sodium chloride zinokuchaphazela kakhulu i-viscosity ye-HPMC ngokubangela utshintsho kwimeko ye-ionization ye-hydroxypropyl kunye namaqela e-methyl.Olu tshintsho luguqula intsebenziswano phakathi kweeamolekyu ze-HPMC, ngaloo ndlela ichaphazela i-viscosity yesisombululo.
ukuququmbela
I-viscosity ye-HPMC ichaphazeleka kwizinto ezininzi, kubandakanywa ubunzima be-molecular, i-degree of substitution, i-concentration, uhlobo lwe-solvent, i-pH, ubushushu kunye namandla e-ionic.Xa uqulunqa iimveliso eziqulathe i-HPMC, kubalulekile ukuqwalasela zonke ezi zinto ukuqinisekisa ukuba i-viscosity efunwayo iyafezekiswa.Ukulungiswa ngokufanelekileyo kwezi zinto kunokubangela ukuqulunqwa kwemveliso esebenzayo kunye nezinzileyo ehlangabezana nenjongo yayo.
Ixesha lokuposa: Sep-12-2023