ewebata
Hydroxypropyl methylcellulose (HPMC) bụ nonionic cellulose ether nke a na-ejikarị eme ihe na ụlọ ọrụ dị iche iche n'ihi ihe ndị magburu onwe ya dị ka mmiri solubility, ihe na-emepụta ihe nkiri, na adhesion.Ikike ya ịgbanwe viscosity na-eme ka ọ dị mma maka ọtụtụ ngwa, gụnyere nri, ọgwụ na agba.A na-enweta HPMC site na cellulose polymer eke, bụ nke glycosylated iji mepụta usoro netwọkụ cellulose-oxygen.Njirimara na viscosity nke HPMC na-adabere n'ihe ndị dị ka ịdị arọ molekụla, ogo nke nnọchi, ntinye uche, ụdị mgbaze, pH, okpomọkụ na ike ionic.
N'isiokwu a, anyị ga-atụle ihe ndị na-emetụta viscosity HPMC na usoro ha.
molekụla arọ
The molekụla arọ nke HPMC tumadi na-ekpebi ya viscosity.N'ụzọ doro anya, ka ịdị arọ ahụ dị elu, ka ọ na-aghọkwu viscous.Arọ molikula nke HPMC sitere na 10^3 ruo 10^6 Da.Ka ịdị arọ molekụla na-abawanye, ọnụọgụ nke njikọ dị n'etiti agbụ HPMC na-abawanye, na-ebute mmụba na viscosity.
Ogo nke nnọchi
Ogo nke nnọchi (DS) nke HPMC na-ekpebi ọnụọgụ hydroxypropyl na otu methyl na nhazi ya.HPMC nwere DS dị elu bụ hydrophobic na obere mmiri soluble karịa HPMC nwere DS dị ala.Ogo nke nnọchi na-emetụta solubility nke HPMC na mmiri, nke n'aka nke ya na-emetụta ike ya ịmepụta netwọk jikọtara ọnụ na ịbawanye viscosity.
lekwasị anya
Ntinye uche bụ otu n'ime ihe kacha mkpa na-emetụta viscosity HPMC.N'ozuzu, viscosity nke HPMC ngwọta na-abawanye na-amụba itinye uche.A na-ekwu na omume a bụ njikọ nke agbụ HPMC n'ogo dị elu.
Ụdị mgbaze
Ụdị ihe mgbaze na-arụ ọrụ dị mkpa na viscosity nke HPMC.N'ọnọdụ ụfọdụ, HPMC nwere viscosity dị elu na mmiri karịa na ụfọdụ ihe mgbaze organic.Ihe kpatara ya nwere ike ịbụ n'ihi mmekọrịta dị iche iche n'etiti ihe mgbaze na ụmụ irighiri ihe HPMC.
pH
PH nke ngwọta nwere ike imetụta viscosity nke HPMC.Na pH acidic, HPMC nwere ike ịmepụta njikọ hydrogen na ihe mgbaze, na-eme ka mmụba nke viscosity.Ọzọkwa, pH na-emetụta ogo ionization nke hydroxypropyl na methyl otu, nke na-emetụta electrostatic na hydrophobic mmekọrịta n'etiti HPMC chains.
okpomọkụ
Okpomọkụ na-enwekwa mmetụta na viscosity nke HPMC.N'ebe okpomọkụ dị elu, ụmụ irighiri ihe HPMC nwere ngagharị dị elu, na-ebute mbelata mmekọrịta intermolecular.Omume a na-ebutekarị mbelata nke viscosity ngwọta.A na-ahụ ọnọdụ dị iche na obere okpomọkụ.N'ihi nkwụsi ike nke mkpụrụ ndụ HPMC, viscosity nke ngwọta na-abawanye na okpomọkụ na-ebelata.
ike ionic
Ike ionic bụ ihe ọzọ na-emetụta viscosity HPMC.Oke a na-ezo aka na ntinye nke ion na ngwọta.Nnu dị ka sodium chloride nwere ike imetụta viscosity nke HPMC nke ukwuu site n'iweta mgbanwe na ọnọdụ ionization nke hydroxypropyl na otu methyl.Mgbanwe a na-agbanwe mmekọrịta dị n'etiti ụmụ irighiri ihe HPMC, si otú a na-emetụta viscosity nke ngwọta.
na ngwụcha
The viscosity nke HPMC na-emetụta ọtụtụ ihe, gụnyere molekul arọ, ogo nke nnọchi, itinye uche, ihe mgbaze ụdị, pH, okpomọkụ na ionic ike.Mgbe ị na-emepụta ngwaahịa nwere HPMC, ọ dị mkpa ịtụle ihe ndị a niile iji hụ na e nwetara viscosity achọrọ.Ịmepụta nke ọma nke ihe ndị a nwere ike ime ka ịmepụta ngwaahịa dị irè ma kwụsie ike nke na-emezu ebumnuche ya.
Oge nzipu: Sep-12-2023