He aha nā mea e pili ana i ka viscosity o HPMC?

hoolauna

ʻO ka Hydroxypropyl methylcellulose (HPMC) he ether nonionic cellulose i hoʻohana nui ʻia i nā ʻoihana like ʻole ma muli o kāna mau waiwai maikaʻi loa e like me ka hoʻoheheʻe wai, ka waiwai hana kiʻiʻoniʻoni, a me ka adhesion.ʻO kona hiki ke hoʻololi i ka viscosity he mea kūpono ia no nā noi he nui, me ka meaʻai, nā lāʻau lapaʻau a me nā pena.Loaʻa ʻia ka HPMC mai ka cellulose polymer maoli, kahi glycosylated e hana i kahi ʻōnaehana pūnaewele cellulose-oxygen.ʻO nā waiwai a me ka viscosity o ka HPMC e hilinaʻi ʻia i nā mea e like me ke kaumaha molekala, degere o ka hoʻololi ʻana, ka ʻike, ke ʻano solvent, pH, ka mahana a me ka ikaika ionic.

Ma kēia ʻatikala, e kūkākūkā mākou i nā mea e hoʻopili ai i ka viscosity HPMC a me kā lākou mau hana.

kaumaha molekala

ʻO ke kaumaha molekala o HPMC ka mea e hoʻoholo ai i kona viscosity.ʻIke loa, ʻoi aku ka kiʻekiʻe o ke kaumaha molekala, ʻoi aku ka ʻoi aku o ka viscous.ʻO ke kaumaha molekala o HPMC mai ka 10^3 a hiki i ka 10^6 Da.Ke piʻi aʻe ka paona molekala, piʻi pū ka helu o nā entanglements ma waena o nā kaulahao HPMC, e hoʻonui ai i ka viscosity.

Degere o ka pani

Hoʻoholo ka degere o ka hoʻololi ʻana (DS) o HPMC i ka helu o nā pūʻulu hydroxypropyl a me methyl i kona ʻano.ʻO ka HPMC me ka DS kiʻekiʻe, ʻoi aku ka hydrophobic a me ka liʻiliʻi o ka wai ma mua o ka HPMC me ka DS haʻahaʻa.Hoʻopili ka degere o ka hoʻololi ʻana i ka solubility o ka HPMC i ka wai, a ʻo ia hoʻi ka hopena i kona hiki ke hana i nā ʻupena pili a hoʻonui i ka viscosity.

kālele

ʻO ka concentrate kekahi o nā mea koʻikoʻi e pili ana i ka viscosity HPMC.ʻO ka maʻamau, piʻi ka viscosity o nā hoʻonā HPMC me ka hoʻonui ʻana i ka ʻike.Hoʻopili ʻia kēia ʻano i ka hoʻopili ʻana o nā kaulahao HPMC i nā kiʻekiʻe kiʻekiʻe.

ʻAno solvent

He kuleana koʻikoʻi ke ʻano o ka solvent i ka viscosity o HPMC.I kekahi mau hihia, ʻoi aku ka nui o ka viscosity o ka HPMC i ka wai ma mua o kekahi mau mea hoʻoheheʻe organik.ʻO ke kumu paha ma muli o nā pilina like ʻole ma waena o ka solvent a me nā molekala HPMC.

pH

Hiki i ka pH o ka hopena ke hoʻololi nui i ka viscosity o HPMC.Ma ka pH ʻakika, hiki i ka HPMC ke hana i nā paʻa hydrogen me ka mea hoʻoheheʻe, e hoʻonui ai i ka viscosity.Eia kekahi, pili ka pH i ke kiʻekiʻe o ka ionization o nā pūʻulu hydroxypropyl a me methyl, ka mea e pili ana i ka pilina electrostatic a me ka hydrophobic ma waena o nā kaulahao HPMC.

mahana wela

He hopena nō hoʻi ka mahana i ka viscosity o HPMC.Ma nā wela kiʻekiʻe, ʻoi aku ka ʻoi aku o ka neʻe ʻana o nā molekala HPMC, e hoʻemi ana i nā pilina intermolecular.ʻO kēia hana maʻamau ka hopena i ka emi ʻana o ka viscosity solution.ʻIke ʻia ke kūlana kūʻē i nā mahana haʻahaʻa.Ma muli o ka paʻakikī o nā molekala HPMC, piʻi ka viscosity o ka hopena me ka emi ʻana o ka mahana.

ikaika ionic

ʻO ka ikaika Ionic kekahi mea e pili ana i ka viscosity HPMC.ʻO kēia ʻāpana e pili ana i ka neʻe ʻana o nā ion i ka hopena.Hiki i nā paʻakai e like me ka sodium chloride ke hoʻololi nui i ka viscosity o ka HPMC ma o ka hoʻoulu ʻana i nā loli i ke kūlana ionization o nā hui hydroxypropyl a me methyl.Hoʻololi kēia hoʻololi i ka pilina ma waena o nā molekala HPMC, a laila e hoʻopili ai i ka viscosity o ka hopena.

i ka hopena

Hoʻopili ʻia ka viscosity o ka HPMC e nā kumu he nui, e like me ke kaumaha molecular, degere o ka hoʻololi ʻana, ka ʻike, ke ʻano solvent, pH, ka mahana a me ka ikaika ionic.I ka hoʻokumu ʻana i nā huahana i loaʻa iā HPMC, pono e noʻonoʻo i kēia mau mea āpau e hōʻoia i ka loaʻa ʻana o ka viscosity i makemake ʻia.ʻO ka hoʻopono kūpono o kēia mau mea hiki ke hopena i ka hoʻokumu ʻana i kahi huahana kūpono a kūpaʻa e kū i kāna kumu i manaʻo ʻia.