tsebisa
Hydroxypropyl methylcellulose (HPMC) ke nonionic cellulose ether e sebelisoang haholo liindastering tse sa tšoaneng ka lebaka la thepa ea eona e babatsehang e kang ho qhibiliha ha metsi, thepa ea ho etsa lifilimi, le ho khomarela.Bokhoni ba eona ba ho fetola viscosity bo etsa hore e be bo loketseng bakeng sa lits'ebetso tse ngata, ho kenyelletsa lijo, meriana le lipente.HPMC e tsoa ho cellulose ea tlhaho ea polymer, e leng glycosylated ho theha sebopeho sa marang-rang sa cellulose-oksijene.Thepa le viscosity ea HPMC e itšetlehile ka lintlha tse kang boima ba limolek'hule, tekanyo ea ho fetola, mahloriso, mofuta oa solvent, pH, mocheso le matla a ionic.
Sehloohong sena, re tla tšohla lintlha tse susumetsang viscosity ea HPMC le mekhoa ea bona.
boima ba molek'hule
Boima ba molek'hule ea HPMC haholo-holo bo lekanyetsa viscosity ea eona.Ho hlakile hore ha boima ba limolek'hule bo phahame, bo ba bo hlakileng haholoanyane.Boima ba molek'hule ea HPMC bo tloha ho 10^3 ho isa ho 10^6 Da.Ha boima ba limolek'hule bo ntse bo eketseha, palo ea likhohlano lipakeng tsa liketane tsa HPMC le eona ea eketseha, e bakang keketseho ea viscosity.
Boemo ba ho nka sebaka
Tekanyo ea ho fetola (DS) ea HPMC e etsa qeto ea palo ea lihlopha tsa hydroxypropyl le methyl sebopeho sa eona.HPMC e nang le DS e phahameng e na le hydrophobic ho feta 'me ha e qhibilihe ka metsing ho feta HPMC e nang le DS e tlase.Tekanyo ea ho kenya sebaka e ama ho qhibiliha ha HPMC metsing, e leng se amang bokhoni ba eona ba ho theha marang-rang a ts'oaretsoeng le ho eketsa viscosity.
tsepamisa maikutlo
Ho tsepamisa maikutlo ke e 'ngoe ea lintlha tsa bohlokoa tse amang HPMC viscosity.Ka kakaretso, viscosity ea tharollo ea HPMC e eketseha ka khatello e ntseng e eketseha.Boitšoaro bona bo bakoa ke ho ts'oaroa ha liketane tsa HPMC maemong a holimo.
Mofuta oa solvent
Mofuta oa solvent o bapala karolo ea bohlokoa ho viscosity ea HPMC.Maemong a mang, HPMC e na le viscosity e phahameng ka metsing ho feta ka har'a metsoako e meng ea tlhaho.Lebaka e kanna ea ba ka lebaka la litšebelisano tse fapaneng lipakeng tsa limolek'hule tsa solvent le HPMC.
pH
PH ea tharollo e ka ama haholo viscosity ea HPMC.Ho acidic pH, HPMC e ka theha maqhama a hydrogen le solvent, e bakang keketseho ea viscosity.Ho feta moo, pH e ama boemo ba ionization ea hydroxypropyl le lihlopha tsa methyl, tse amang tšebelisano ea motlakase le hydrophobic lipakeng tsa liketane tsa HPMC.
mocheso
Mocheso o boetse o na le phello ho viscosity ea HPMC.Lithempereichara tse phahameng, limolek'hule tsa HPMC li na le motsamao o phahameng, e leng se bakang ho fokotseha ha likamano tsa li-intermolecular.Boitšoaro bona hangata bo fella ka ho fokotseha ha viscosity ea tharollo.Boemo bo fapaneng bo bonoa ka mocheso o tlase.Ka lebaka la ho tiea ha limolek'hule tsa HPMC, viscosity ea tharollo e eketseha ka mocheso o fokolang.
matla a ionic
Matla a ionic ke ntlha e 'ngoe e amang viscosity ea HPMC.Paramethara ena e bua ka bongata ba li-ion tharollong.Matsoai a kang sodium chloride a ka ama viscosity ea HPMC haholo ka ho etsa hore ho be le liphetoho boemong ba ionization ba lihlopha tsa hydroxypropyl le methyl.Phetoho ena e fetola litšebelisano pakeng tsa limolek'hule tsa HPMC, kahoo e ama viscosity ea tharollo.
ha re phethela
The viscosity ea HPMC angoa ke lintho tse ngata, ho akarelletsa le boima ba molek'hule, tekanyo ea ho fetola, mahloriso, mofuta oa solvent, pH, mocheso le matla a ionic.Ha ho etsoa lihlahisoa tse nang le HPMC, ho bohlokoa ho nahana ka lintlha tsena kaofela ho netefatsa hore viscosity e lakatsehang e ea fihlelleha.Ntlafatso e nepahetseng ea lintlha tsena e ka fella ka tlhahiso ea sehlahisoa se sebetsang hantle le se tsitsitseng se fihlelang sepheo sa sona.
Nako ea poso: Sep-12-2023