gabatar
Hydroxypropyl methylcellulose (HPMC) wani nonionic cellulose ether ne wanda aka yi amfani da shi sosai a masana'antu daban-daban saboda kyawawan kaddarorinsa irin su solubility na ruwa, kayan samar da fim, da mannewa.Ƙarfinsa don canza danko ya sa ya dace don aikace-aikace da yawa, gami da abinci, magunguna da fenti.An samo HPMC daga cellulose polymer na halitta, wanda aka glycosylated don samar da tsarin cibiyar sadarwa na cellulose-oxygen.Kaddarorin da danko na HPMC sun dogara da dalilai kamar nauyin kwayoyin halitta, matakin maye gurbin, maida hankali, nau'in sauran ƙarfi, pH, zafin jiki da ƙarfin ionic.
A cikin wannan labarin, za mu tattauna abubuwan da ke tasiri danko na HPMC da hanyoyin su.
nauyin kwayoyin halitta
Nauyin kwayoyin halitta na HPMC yafi kayyade danko.Babu shakka, yayin da mafi girman nauyin kwayoyin halitta, zai zama mafi danko.Nauyin kwayoyin halitta na HPMC yana daga 10^3 zuwa 10^6 Da.Yayin da nauyin kwayoyin halitta ya karu, adadin ruɗewa tsakanin sarƙoƙi na HPMC kuma yana ƙaruwa, yana haifar da karuwa a cikin danko.
Digiri na canji
Matsayin maye gurbin (DS) na HPMC yana ƙayyade adadin hydroxypropyl da ƙungiyoyin methyl a cikin tsarin sa.HPMC tare da mafi girma DS ya fi hydrophobic kuma ƙasa da ruwa mai narkewa fiye da HPMC tare da ƙananan DS.Matsayin maye gurbin yana rinjayar solubility na HPMC a cikin ruwa, wanda hakan yana rinjayar ikonsa na samar da hanyoyin sadarwa da kuma ƙara danko.
mayar da hankali
Hankali yana ɗaya daga cikin mahimman abubuwan da ke shafar dankowar HPMC.Gabaɗaya, danko na mafita na HPMC yana ƙaruwa tare da haɓaka haɓakawa.Ana danganta wannan halin zuwa ga haɗa sarƙoƙi na HPMC a mafi girman taro.
Nau'in narkewa
Nau'in sauran ƙarfi yana taka muhimmiyar rawa a cikin danko na HPMC.A wasu lokuta, HPMC yana da ɗanko mafi girma a cikin ruwa fiye da wasu kaushi na halitta.Dalilin yana iya zama saboda ma'amala daban-daban tsakanin sauran ƙarfi da kwayoyin HPMC.
pH
pH na maganin zai iya tasiri sosai ga danko na HPMC.A pH acidic, HPMC na iya samar da haɗin gwiwar hydrogen tare da sauran ƙarfi, yana haifar da karuwa a cikin danko.Bugu da ƙari kuma, pH yana rinjayar matakin ionization na hydroxypropyl da ƙungiyoyin methyl, wanda hakan ya shafi hulɗar electrostatic da hydrophobic tsakanin sarƙoƙi na HPMC.
zafin jiki
Hakanan yanayin zafi yana da tasiri akan dankowar HPMC.A yanayin zafi mafi girma, kwayoyin HPMC suna da motsi mafi girma, yana haifar da raguwar hulɗar intermolecular.Wannan hali yawanci yana haifar da raguwa a cikin dankowar bayani.Ana lura da akasin yanayin a ƙananan yanayin zafi.Saboda rigidity na kwayoyin HPMC, dankowar maganin yana ƙaruwa tare da rage yawan zafin jiki.
ƙarfin ionic
Ƙarfin Ionic wani abu ne wanda ke shafar dankowar HPMC.Wannan siga yana nufin ƙaddamar da ions a cikin maganin.Gishiri irin su sodium chloride na iya tasiri sosai ga danko na HPMC ta hanyar haifar da canje-canje a cikin yanayin ionization na hydroxypropyl da ƙungiyoyin methyl.Wannan canjin yana canza mu'amala tsakanin kwayoyin HPMC, ta haka yana shafar ɗankowar maganin.
a karshe
Dankowar HPMC yana shafar abubuwa da yawa, gami da nauyin kwayoyin halitta, matakin maye gurbin, maida hankali, nau'in sauran ƙarfi, pH, zafin jiki da ƙarfin ionic.Lokacin ƙirƙirar samfuran da ke ɗauke da HPMC, yana da mahimmanci a yi la'akari da duk waɗannan abubuwan don tabbatar da samun ɗanƙon da ake so.Haɓakawa da kyau na waɗannan abubuwan na iya haifar da ƙirƙirar samfur mai inganci kuma barga wanda ya dace da manufar sa.
Lokacin aikawa: Satumba-12-2023