Ukulungiselela i-hydroxypropyl methylcellulose (HPMC) izisombululo zokugquma kubandakanya amanyathelo amaninzi kwaye kufuna ingqalelo enonophelo kwiinkcukacha.I-HPMC iqhele ukusetyenziswa njengesixhobo sokugquma ifilimu kumashishini oxubo mayeza kunye nokutya.Izisombululo zokugqoka zisetyenziselwa iipilisi okanye iigranules ukubonelela ngoluhlu olukhuselayo, ukuphucula ukubonakala, kunye nokuququzelela ukugwinya.
1. Intshayelelo yokwaleka kweHPMC:
IHydroxypropylmethylcellulose (HPMC) yi-cellulose-based polymer ephuma kwimicu yezityalo.Ngenxa yeempawu zayo zokwenza ifilimu kunye nokuqina, isetyenziswa ngokubanzi kwiingubo zefilimu kumashishini amayeza kunye nokutya.
2. Imathiriyeli efunekayo:
I-Hydroxypropyl methylcellulose powder
Hlambulula amanzi
Izikhongozeli zePlastiki okanye zensimbi engenasici
Izixhobo ezishukumisayo (umz. imagnethi yokushukuma)
Izixhobo zokulinganisa (izikali, iisilinda zokulinganisa)
imitha ye-pH
Iplastiki okanye i-pan yokugquma intsimbi
I-oveni yomoya oshushu
3.inkqubo:
Yenza umlinganiselo weHPMC:
Ukulinganisa ngokuchanekileyo inani elifunekayo lepowder ye-HPMC esekelwe kuyilo olufunwayo lwengubo.Ugxininiso ludla ngokuba phakathi kwe-2% kunye ne-10%.
Lungisa amanzi acocekileyo:
Sebenzisa amanzi ahlanjululweyo ukuqinisekisa ukuba ayinakungcoliswa okunokuchaphazela umgangatho wengubo.Amanzi kufuneka abe kwiqondo lobushushu begumbi.
Ukusasazwa kwe-HPMC:
Yongeza kancinane umgubo we-HPMC olinganisiweyo kumanzi ahlambulukileyo ngelixa uvuselela ngokuqhubekayo.Oku kuthintela ukuba i-clumps yenze.
Gxuma:
Gxuma umxube usebenzisa i-stirrer magnetic okanye esinye isixhobo esifanelekileyo esishukumisayo de umgubo we-HPMC uhlakazwe ngokupheleleyo emanzini.
Uhlengahlengiso lwe-pH:
Ukulinganisa i-pH yesisombululo se-HPMC usebenzisa imitha ye-pH.Ukuba kuyimfuneko, i-pH inokulungelelaniswa ngokongeza inani elincinci le-asidi okanye isiseko ngokufanelekileyo.I-pH efanelekileyo yokugquma ifilimu idla ngokuba kuluhlu lwe-5.0 ukuya kwi-7.0.
Ukufuma kunye nokuguga:
Isisombululo se-HPMC sivumelekile ukuba sifakwe emanzini kunye nobudala bexesha elithile.Oku kwandisa iipropati zokwenza ifilimu.Ixesha lokuguga linokwahluka kodwa ngokuqhelekileyo likuluhlu lweeyure ezi-2 ukuya kwezingama-24.
isihluzi:
Hlunga isisombululo se-HPMC ukususa nawaphi na amasuntswana anganyibilikiyo okanye ukungcola.Eli nyathelo liyimfuneko ukuze ufumane isisombululo esigudileyo, esicacileyo sokugquma.
Uhlengahlengiso lweViscosity:
Ukulinganisa i-viscosity yesisombululo kwaye uyilungelelanise kwinqanaba elifunekayo.I-Viscosity ichaphazela ukufana kunye nobukhulu bengubo.
Ukuhambelana kovavanyo:
Ukuvavanya ukuhambelana kwesisombululo sokugubungela kunye ne-substrate (iipilisi okanye i-granules) ukuqinisekisa ukunamathela ngokufanelekileyo kunye nokwakheka kwefilimu.
Inkqubo yokwaleka:
Sebenzisa i-pan yokugqoka efanelekileyo kwaye usebenzise umatshini wokugquma ukusebenzisa isisombululo se-HPMC sokugubungela kwiipilisi okanye iigranules.Lungisa isantya sembiza kunye neqondo lobushushu lomoya ukuze ufumane ukutyabeka kakuhle.
ukomisa:
Iipilisi okanye i-granules ezigqunyiweyo zomiswa kwi-oven yomoya oshushu olawulwa ngubushushu kuze kube yilapho ubukhulu obufunwayo bufezekiswa.
QC:
Ukuqhuba uvavanyo lokulawula umgangatho weemveliso ezigqunyiweyo kubandakanywa inkangeleko, ubukhulu kunye neempawu zokutshatyalaliswa.
4. Ekuqukumbeleni:
Ukulungiswa kwezisombululo zokugquma kwe-HPMC kubandakanya uthotho lwamanyathelo achanekileyo okuqinisekisa umgangatho kunye nokusebenza kakuhle kwengubo.Ukuthotyelwa kweenkqubo ezimiselweyo kunye namanyathelo okulawula umgangatho kubalulekile ekufumaneni iziphumo ezihambelanayo nezithembekileyo kumashishini amayeza kunye nokutya.Ngalo lonke ixesha ulandela i-Good Manufacturing Practices (GMP) kunye nezikhokelo ezihambelanayo ngexesha lenkqubo yokugubungela.
Ixesha lokuposa: Jan-18-2024