Ho lokisa tharollo ea hydroxypropyl methylcellulose (HPMC) ho kenyelletsa mehato e mengata mme ho hloka tlhokomelo e hlokolosi ho lintlha.HPMC e atisa ho sebelisoa e le thepa ea ho roala filimi indastering ea meriana le ea lijo.Litharollo tsa ho roala li sebelisoa matlapeng kapa li-granules ho fana ka lera le sireletsang, ho ntlafatsa ponahalo, le ho nolofatsa ho metsa.
1. Kenyelletso ea ho roala HPMC:
Hydroxypropylmethylcellulose (HPMC) ke polymer e entsoeng ka selulose e nkiloeng ho likhoele tsa semela.Ka lebaka la thepa ea eona ea ho etsa filimi le e teteaneng, e sebelisoa haholo ka ho roala lifilimi ho indasteri ea meriana le ea lijo.
2. Lisebelisoa tse hlokahalang:
Hydroxypropyl methylcellulose phofo
Hloekisa metsi
Lijana tsa polasetiki kapa tse se nang tšepe
Thepa e hlohlelletsang (mohlala, magnetic stirrer)
Lisebelisoa tsa ho lekanya (likarolo, lisilindara)
pH metara
Plastiki kapa tšepe e sa hloekang ea ho roala pan
Setofo sa moea o chesang
3.lenaneo:
Leka HPMC:
Lekanya ka nepo palo e hlokahalang ea phofo ea HPMC ho latela mokhoa o lakatsehang oa ho roala.Hangata likhakanyo li pakeng tsa 2% le 10%.
Lokisetsa metsi a hloekisitsoeng:
Sebelisa metsi a hloekisitsoeng ho netefatsa hore ha a na litšila tse ka amang boleng ba ho roala.Metsi a lokela ho ba mocheso oa kamore.
Phatlalatso ea HPMC:
Butle-butle eketsa phofo ea HPMC e lekantsoeng metsing a hloekisitsoeng ha u ntse u susumetsa ka ho tsoelang pele.Sena se thibela li-clumps ho theha.
Hlohlelletsa:
Hlohlelletsa motsoako o sebelisa mochine oa magnetic stirrer kapa sesebelisoa se seng se loketseng se susumetsang ho fihlela phofo ea HPMC e hasane ka ho feletseng metsing.
Phetoho ea pH:
Lekanya pH ya tharollo ya HPMC o sebedisa pH meter.Haeba ho hlokahala, pH e ka fetoloa ka ho eketsa palo e nyane ea asiti kapa setsi ho latela.PH e nepahetseng ea ho roala filimi hangata e pakeng tsa 5.0 le 7.0.
Moisturizing le botsofali:
Tharollo ea HPMC e lumelloa ho fana ka metsi le ho tsofala ka nako e itseng.Sena se ntlafatsa thepa ea ho etsa lifilimi.Nako ea botsofali e ka 'na ea fapana empa hangata e pakeng tsa lihora tse 2 ho isa ho tse 24.
sefe:
Sefa tharollo ea HPMC ho tlosa likaroloana tse sa qhibilihang kapa litšila.Mohato ona ke oa bohlokoa ho fumana tharollo e boreleli, e hlakileng ea ho roala.
Ho lokisoa ha viscosity:
Lekanya viscosity ea tharollo 'me u e fetole ho ea boemong bo lakatsehang.Viscosity e ama ho tšoana le botenya ba ho roala.
Teko e tsamaellana:
Lekola ho lumellana ha tharollo ea ho roala le substrate (matlapa kapa granules) ho etsa bonnete ba ho khomarela hantle le sebopeho sa filimi.
Mokhoa oa ho roala:
Sebelisa pane e loketseng ea ho roala 'me u sebelise mochini oa ho roala ho kenya tharollo ea HPMC ho matlapa kapa li-granules.Fetola lebelo la pitsa le mocheso oa moea bakeng sa ho roala hantle.
ho omisa:
Matlapa kapa li-granules tse koahetsoeng li omisitsoe ka ontong ea moea o chesang o laoloang ke mocheso ho fihlela botenya bo lakatsehang bo finyelloa.
QC:
Etsa tlhahlobo ea taolo ea boleng ba lihlahisoa tse koahetsoeng ho kenyelletsa ponahalo, botenya le thepa ea ho qhibiliha.
4. Qetellong:
Ho lokisoa ha litharollo tsa ho roala HPMC ho kenyelletsa letoto la mehato e nepahetseng ho netefatsa boleng le katleho ea ho roala.Ho khomarela mekhoa e behiloeng le mehato ea ho laola boleng ho bohlokoa ho fumana liphello tse tsitsitseng le tse ka tšeptjoang indastering ea meriana le ea lijo.Kamehla latela Mekhoa e Metle ea Tlhahiso (GMP) le litataiso tse amanang le tsona nakong ea ho roala.
Nako ea poso: Jan-18-2024