Kodi mungakonzekere bwanji yankho la zokutira la HPMC?

Kukonzekera njira zokutira za hydroxypropyl methylcellulose (HPMC) kumaphatikizapo masitepe angapo ndipo kumafuna kusamalitsa mwatsatanetsatane.HPMC imagwiritsidwa ntchito ngati chotchingira filimu m'mafakitale azamankhwala ndi zakudya.Njira zokutira zimagwiritsidwa ntchito pamapiritsi kapena ma granules kuti apereke chitetezo, kusintha maonekedwe, ndikuthandizira kumeza.

1. Chiyambi cha zokutira za HPMC:

Hydroxypropylmethylcellulose (HPMC) ndi polima yopangidwa ndi cellulose yochokera ku ulusi wa zomera.Chifukwa cha mawonekedwe ake opanga mafilimu ndi makulidwe, amagwiritsidwa ntchito kwambiri popaka mafilimu m'makampani opanga mankhwala ndi zakudya.

2. Zida zofunika:

Hydroxypropyl methylcellulose ufa
Yeretsani madzi
Zotengera za pulasitiki kapena zitsulo zosapanga dzimbiri
Zipangizo zoyambukira (monga maginito osonkhezera)
Zida zoyezera (sikelo, masilindala)
pH mita
Pulasitiki kapena zitsulo zosapanga dzimbiri zokutira poto
Uvuni wa mpweya wotentha

3. Pulogalamu:

Kuyeza HPMC:

Yezerani molondola kuchuluka kwa ufa wa HPMC potengera kapangidwe kake komwe mukufuna.Nthawi zambiri zimakhala pakati pa 2% ndi 10%.

Konzani madzi oyeretsedwa:

Gwiritsani ntchito madzi oyeretsedwa kuti muwonetsetse kuti alibe zonyansa zomwe zingakhudze ubwino wa zokutira.Madzi ayenera kukhala kutentha.

Kubalalika kwa HPMC:

Pang'onopang'ono yonjezerani ufa wa HPMC wolemera m'madzi oyeretsedwa pamene mukugwedeza mosalekeza.Izi zimalepheretsa kupanga clumps.

Limbikitsani:

Sakanizani chisakanizocho pogwiritsa ntchito maginito osonkhezera kapena chipangizo china choyenera chogwedeza mpaka ufa wa HPMC utamwazikana m'madzi.

Kusintha kwa pH:

Yezerani pH ya yankho la HPMC pogwiritsa ntchito mita ya pH.Ngati ndi kotheka, pH ikhoza kusinthidwa ndikuwonjezera pang'ono asidi kapena maziko molingana.Mulingo woyenera kwambiri wa pH wokutira filimu nthawi zambiri umakhala pakati pa 5.0 mpaka 7.0.

Moisturizing ndi kukalamba:

Yankho la HPMC limaloledwa kuthira madzi ndi kukalamba kwa nthawi inayake.Izi zimawonjezera mawonekedwe opanga mafilimu.Nthawi yokalamba imatha kusiyanasiyana koma nthawi zambiri imakhala ya maola awiri mpaka 24.

fyuluta:

Sefa njira ya HPMC kuti muchotse tinthu tating'onoting'ono tomwe tasungunuka kapena zonyansa.Njira imeneyi ndi yofunika kwambiri kuti mupeze njira yothetsera yosalala, yomveka bwino.

Kusintha kwa viscosity:

Kuyeza mamasukidwe akayendedwe a yankho ndi kusintha kwa mlingo wofunidwa.Viscosity imakhudza kufanana ndi makulidwe a zokutira.

Kuyenderana ndi mayeso:

Yesani kugwirizana kwa yankho la zokutira ndi gawo lapansi (mapiritsi kapena ma granules) kuti muwonetsetse kumamatira koyenera komanso kupanga filimu.

Njira yokutira:

Gwiritsani ntchito poto yoyakira yoyenera ndikugwiritsa ntchito makina opaka kuti mugwiritse ntchito yankho la HPMC pamapiritsi kapena ma granules.Sinthani liwiro la mphika ndi kutentha kwa mpweya kuti muzitha kuyanika bwino.

kuyanika:

Mapiritsi ophimbidwa kapena ma granules amawumitsidwa mu uvuni wotentha woyendetsedwa ndi kutentha mpaka makulidwe omwe amafunidwa akwaniritsidwa.

QC:

Yesetsani kuwongolera khalidwe lazinthu zokutidwa kuphatikizapo maonekedwe, makulidwe ndi kusungunuka kwa katundu.

4. Pomaliza:

Kukonzekera kwa mayankho a HPMC kumaphatikizapo njira zingapo zowonetsetsa kuti zokutira zili bwino komanso zogwira mtima.Kutsatira ndondomeko zovomerezeka ndi njira zoyendetsera khalidwe ndizofunikira kuti tipeze zotsatira zokhazikika komanso zodalirika m'makampani opanga mankhwala ndi zakudya.Nthawi zonse tsatirani Njira Zabwino Zopangira (GMP) ndi malangizo okhudzana nawo pakuyala.