Olee otú iji kwadebe HPMC mkpuchi ngwọta?

Ịkwadebe hydroxypropyl methylcellulose (HPMC) ngwọta mkpuchi gụnyere ọtụtụ usoro ma chọọ nlezianya anya na nkọwa.A na-ejikarị HPMC eme ihe dị ka ihe mkpuchi ihe nkiri na ụlọ ọrụ ọgwụ na nri.A na-etinye ihe mkpuchi mkpuchi na mbadamba nkume ma ọ bụ granules iji nye oyi akwa nchebe, meziwanye ọdịdị, na ịkwado ilo.

1. Okwu Mmalite nke HPMC mkpuchi:

Hydroxypropylmethylcellulose (HPMC) bụ polymer sitere na cellulose sitere na eriri osisi.N'ihi ihe nkiri na-emepụta ihe na-emepụta ihe na-emepụta ihe, a na-ejikarị ya eme ihe na mkpuchi ihe nkiri na ụlọ ọrụ ọgwụ na nri.

2. Ihe achọrọ:

Hydroxypropyl methylcellulose ntụ ntụ
Mee ka mmiri dị ọcha
Akpa plastik ma ọ bụ igwe anaghị agba nchara
Akụrụngwa na-akpali akpali (dịka magnetik stirrer)
Ngwa eji atụ ihe (ihe ọ̀tụ̀tụ̀, ihe ọ̀tụ̀tụ̀ cylinders)
mita pH
Ihe mkpuchi plastik ma ọ bụ igwe anaghị agba nchara
Igwe ọkụ ikuku na-ekpo ọkụ

3. mmemme:

Tulee HPMC:

Jiri nlezianya tụlee ego achọrọ nke HPMC ntụ ntụ dabere na nhazi mkpuchi achọrọ.Ntinye uche na-adịkarị n'etiti 2% na 10%.

Kwadebe mmiri dị ọcha:

Jiri mmiri dị ọcha mee ka ọ ghara ịdị ọcha nke nwere ike imetụta àgwà mkpuchi ahụ.Mmiri kwesịrị ịdị na ụlọ okpomọkụ.

Mgbasa nke HPMC:

Jiri nwayọ tinye ntụ ntụ HPMC a tụrụ atụ na mmiri a na-eme ka ọ dị ọcha ka ị na-akpalite mgbe niile.Nke a na-egbochi clumps ịmalite.

kpalite:

Mee ka ngwakọta na-eji magnetik stirrer ma ọ bụ ngwaọrụ mkpagharị ọzọ kwesịrị ekwesị ruo mgbe HPMC ntụ ntụ na-agbasasị kpamkpam na mmiri.

Nhazi pH:

Tụọ pH nke ngwọta HPMC site na iji mita pH.Ọ bụrụ na ọ dị mkpa, enwere ike gbanwee pH site na ịgbakwunye ntakịrị acid ma ọ bụ isi ya.PH kacha mma maka mkpuchi ihe nkiri na-abụkarị 5.0 ruo 7.0.

Moisturizing na ịka nká:

A na-ahapụ ngwọta HPMC ka ọ na-agbapụta mmiri ma mee ka ọ dị afọ ruo oge ụfọdụ.Nke a na-eme ka ihe ndị na-emepụta ihe nkiri dịkwuo elu.Oge ịka nká nwere ike ịdị iche mana ọ na-adịkarị n'ime awa 2 ruo 24.

nyo:

Wepụ ihe ngwọta HPMC iji wepụ irighiri ihe ọ bụla na-agbazebeghị ma ọ bụ adịghị.Nzọụkwụ a dị mkpa iji nweta ngwọta mkpuchi dị nro, doro anya.

Ndozi viscosity:

Tụlee viscosity nke ngwọta ma dozie ya na ọkwa achọrọ.Viscosity na-emetụta ịdị n'otu na ọkpụrụkpụ nke mkpuchi.

Ndakọrịta nwale:

Nyochaa ndakọrịta nke ngwọta mkpuchi na mkpụrụ (mbadamba ma ọ bụ granules) iji hụ na adhesion kwesịrị ekwesị na mmepụta ihe nkiri.

Usoro mkpuchi:

Jiri pan mkpuchi kwesịrị ekwesị ma jiri igwe mkpuchi tinye ihe ngwọta mkpuchi HPMC na mbadamba nkume ma ọ bụ granules.Gbanwee ọsọ ite na okpomọkụ ikuku maka mkpuchi kacha mma.

ihicha:

A na-akpọ mbadamba mbadamba nkume ma ọ bụ granules n'ime ọkụ ọkụ na-ekpo ọkụ na-achịkwa ruo mgbe a ga-enweta ọkpụrụkpụ mkpuchi achọrọ.

QC:

Mee nnwale njikwa mma nke ngwaahịa mkpuchi gụnyere ọdịdị, ọkpụrụkpụ na ihe mgbaze.

4.n'ikpeazụ:

Nkwadebe nke ngwọta mkpuchi HPMC gụnyere usoro usoro ziri ezi iji hụ na ịdị mma na ịdị irè nke mkpuchi ahụ.Irube isi na usoro edepụtara na njikwa mma dị oke mkpa iji nweta nsonaazụ na-agbanwe agbanwe na ntụkwasị obi na ụlọ ọrụ ọgwụ na nri.Soro Usoro Nrụpụta Dị Mma (GMP) yana ụkpụrụ ndị yiri ya n'oge usoro mkpuchi.