IHydroxypropylmethylcellulose (HPMC) iphuma ku-cellulose esetshenziswa kabanzi ezimbonini ezahlukahlukene ezifana nemithi, ukudla kanye nezimonyo.I-polymer esebenzayo engakha ijeli ngaphansi kwezimo ezithile, futhi izinga lokushisa layo lejeli liyimpahla ebalulekile.
Ithempelesha ye-HPMC ye-gelation isho izinga lokushisa lapho i-polymer ingena khona uguquko lwesigaba ukusuka esixazululo ukuya esimweni sejeli.Inqubo ye-gelation ithintwa yizici ezihlukahlukene, okuhlanganisa ukugxila kwe-HPMC esixazululweni, ukuba khona kwezinye izinto, nezimo zemvelo.
Izinga lokushisa le-gelation le-HPMC lithintwa izinga lokushintshwa kwe-hydroxypropyl namaqembu e-methyl kumgogodla we-cellulose.Amadigri aphezulu okushintsha ngokuvamile aholela emazingeni okushisa aphansi e-gelation.Ngaphezu kwalokho, ukugxila kwe-HPMC esixazululweni nakho kudlala indima ebalulekile.Ukugxila okuphezulu ngokuvamile kubangela amazinga okushisa aphansi e-gelling.
I-gelation mechanism ye-HPMC ihilela ukwakheka kwenethiwekhi enezinhlangothi ezintathu zamaketanga e-polymer ngokusebenzisa i-intermolecular association (isb, i-hydrogen bonding).Lesi sakhiwo senethiwekhi sinquma izici ezibonakalayo zejeli, njenge-viscosity namandla emishini.
Ukuqonda izinga lokushisa le-gelation le-HPMC kubalulekile ezinhlelweni ezihlukahlukene.Isibonelo, emkhakheni wezokwenziwa kwemithi, kubalulekile ekuthuthukisweni kwezinhlelo ezilawulwayo zokulethwa kwezidakamizwa.Izinga lokushisa le-Gelation linquma isikhathi esisithathayo ukuze i-matrix yejeli yakheke emgudwini wokugaya ukudla, ngaleyo ndlela kuthinte i-kinetics yokukhululwa kwezidakamizwa.
Ekwakhekeni kokudla nezimonyo, izinga lokushisa lejeli le-HPMC libalulekile ukulawula ukuthungwa nokuqina komkhiqizo.Kuthinta izici ezifana nokunambitha, ukubukeka nempilo yeshalofu.I-HPMC ivamise ukusetshenziswa njenge-thickener noma i-ejenti ye-gelling kulezi zimboni.
Amasu amaningana angasetshenziswa ukukala nokulawula izinga lokushisa lejeli le-HPMC.I-Differential scanning calorimetry (DSC) kanye nezifundo ze-rheological izindlela ezivamile zokuveza izakhiwo ezishisayo nemishini yamajeli e-HPMC.Ngokulungisa izici ezifana nokugxilisa ingqondo nokuba khona kwezithasiselo, abakhi bangakwazi ukulungisa izinga lokushisa le-gelation ukuze lihlangabezane nezidingo ezithile zohlelo lokusebenza.
Kafushane, izinga lokushisa lejeli le-hydroxypropyl methylcellulose liyipharamitha ebalulekile ezimbonini ezahlukahlukene.Umthelela wayo ezimpahleni zejeli uwenza ube yinto ebalulekile yokusetshenziswa kusukela kwezemithi kuya kokudla nezimonyo.Ukuqonda izici ezithonya izinga lokushisa lejeli le-HPMC kuvumela ukulawula okunembile kanye nokwenza kahle kokusetshenziswa kwayo ekwenziweni okuhlukile.
Isikhathi sokuthumela: Dec-11-2023