Hydroxypropylmethylcellulose (HPMC) ke derivative ea cellulose e sebelisoang haholo liindastering tse fapaneng joalo ka meriana, lijo le litlolo.Ke polymer e sebetsang ka bongata e ka etsang gel tlas'a maemo a itseng, 'me mocheso oa eona oa gel ke thepa ea bohlokoa.
Mocheso oa mocheso oa HPMC o bolela mocheso oo polima e kenang ho oona ho tloha ho tharollo ho ea ho boemo ba gel.Ts'ebetso ea gelation e angoa ke lintlha tse fapaneng, ho kenyelletsa le khatello ea maikutlo ea HPMC tharollong, boteng ba lintho tse ling, le maemo a tikoloho.
Thempereichara ea gelation ea HPMC e angoa ke tekanyo ea ho nkela sebaka sa hydroxypropyl le lihlopha tsa methyl mokokotlong oa cellulose.Likhato tse phahameng tsa ho nka sebaka ka kakaretso li baka mocheso o tlase oa gelation.Ntle le moo, khatello ea HPMC tharollong le eona e bapala karolo ea bohlokoa.Lithempereichara tse phahameng hangata li baka mocheso o tlase oa gelling.
Mochine oa gelation oa HPMC o kenyelletsa ho thehoa ha marang-rang a mararo a marang-rang a liketane tsa polymer ka ho kopana ha limolek'hule (mohlala, hydrogen bonding).Sebopeho sena sa marang-rang se etsa qeto ea hore na ke lintho life tsa 'mele tsa gel, tse kang viscosity le matla a mochine.
Ho utloisisa mocheso oa gelation oa HPMC ho bohlokoa bakeng sa lits'ebetso tse fapaneng.Ka mohlala, lefapheng la meriana, ho bohlokoa bakeng sa nts'etsopele ea mekhoa e laoloang ea phepelo ea meriana.Thempereichara ea Gelation e etsa qeto ea nako eo e e nkang hore gel matrix e thehoe ka har'a tšilo ea lijo, ka hona e ama kinetics ea tokollo ea lithethefatsi.
Lijong le litlolong tsa litlolo, mocheso oa gel oa HPMC o bohlokoa ho laola sebopeho sa sehlahisoa le botsitso.E ama lintlha tse kang tatso, ponahalo le bophelo ba sethala.HPMC e atisa ho sebelisoa e le motenya kapa moemeli oa gelling liindastering tsena.
Mekhoa e mengata e ka sebelisoa ho lekanya le ho laola mocheso oa gel oa HPMC.Differential scanning calorimetry (DSC) le lithuto tsa rheological ke mekhoa e tloaelehileng ea ho khetholla thepa ea mocheso le mochini oa li-gel tsa HPMC.Ka ho fetola lintlha tse kang ho tsepamisa mohopolo le boteng ba li-additives, li-formalator li ka fetola mocheso oa gelation ho finyella litlhoko tse khethehileng tsa kopo.
Ka kakaretso, mocheso oa gel ea hydroxypropyl methylcellulose ke paramente ea bohlokoa bakeng sa liindasteri tse fapaneng.Tšusumetso ea eona ho thepa ea li-gel e etsa hore e be thepa ea bohlokoa bakeng sa likopo ho tloha ho meriana ho ea ho lijo le litlolo.Ho utloisisa lintlha tse susumetsang mocheso oa gel ea HPMC ho lumella taolo e nepahetseng le ho ntlafatsa ts'ebeliso ea eona mefuteng e fapaneng.
Nako ea poso: Dec-11-2023