IHydroxypropylmethylcellulose (HPMC) iphuma kwi cellulose esetyenziswa kakhulu kumashishini ahlukeneyo afana namayeza, ukutya kunye nezithambiso.I-polymer esebenzayo enokuthi yenze i-gel phantsi kweemeko ezithile, kwaye ukushisa kwayo kwe-gel kuyipropati ebalulekileyo.
Iqondo lobushushu le-HPMC libhekisa kwiqondo lobushushu apho ipholima ingena kwinguqu yesigaba ukusuka kwisisombululo ukuya kwimeko yejeli.Inkqubo ye-gelation ichatshazelwa yizinto ezahlukeneyo, kubandakanya ukuxinana kwe-HPMC kwisisombululo, ubukho bezinye izinto, kunye neemeko zokusingqongileyo.
Ubushushu be-gelation ye-HPMC buchatshazelwa yinqanaba lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl kumqolo we-cellulose.Amanqanaba aphezulu okutshintsha ngokubanzi akhokelela kumaqondo asezantsi e-gelation.Ngaphaya koko, ukugxila kwe-HPMC kwisisombululo kukwadlala indima ebalulekileyo.Uxinzelelo oluphezulu lukhokelela kubushushu obuphantsi be-gelling.
I-gelation mechanism ye-HPMC ibandakanya ukusekwa kothungelwano lwe-dimensional-dimensional network of polymer chain ngokusebenzisa i-intermolecular association (umz., i-hydrogen bonding).Esi sakhiwo sothungelwano sinquma iipropati ezibonakalayo ze-gel, ezifana ne-viscosity kunye namandla omatshini.
Ukuqonda ubushushu be-gelation ye-HPMC kubalulekile kwizicelo ezahlukeneyo.Umzekelo, kwinkalo yoxubo-mayeza, kubalulekile kuphuhliso lweenkqubo zokuhanjiswa kweziyobisi ezilawulwayo.Ubushushu be-Gelation bumisela ixesha elithathayo ukuze i-matrix ye-gel yenze kwi-digestive tract, ngaloo ndlela ichaphazela i-kinetics yokukhululwa kweziyobisi.
Kwizinto zokutya kunye neendlela zokuthambisa, ubushushu bejeli ye-HPMC bubalulekile ukulawula ukuthungwa kwemveliso kunye nokuzinza.Ichaphazela izinto ezifana nencasa, inkangeleko kunye nobomi beshelufu.I-HPMC isoloko isetyenziswa njenge-thickener okanye i-agent ye-gelling kula mashishini.
Iindlela ezininzi zingasetyenziswa ukulinganisa nokulawula ubushushu bejeli yeHPMC.Umahluko ukuskena calorimetry (DSC) kunye nezifundo rheological iindlela eziqhelekileyo uphawu iimpawu thermal kunye nomatshini iijeli HPMC.Ngokuhlenga-hlengisa izinto ezinje ngoxinaniso kunye nobukho bezongezo, iifomyula zinokulungisa ubushushu be-gelation ukuhlangabezana neemfuno ezithile zesicelo.
Isishwankathelo, ubushushu bejeli ye-hydroxypropyl methylcellulose yiparameter ebalulekileyo kumashishini ahlukeneyo.Impembelelo yayo kwiipropati ze-gel yenza ukuba ibe yinto exabisekileyo kwizicelo ezivela kwi-pharmaceuticals ukuya kukutya kunye nezithambiso.Ukuqonda izinto eziphembelela ubushushu bejeli ye-HPMC ivumela ulawulo oluchanekileyo kunye nokuphucula ukusetyenziswa kwayo kwiindlela ezahlukeneyo.
Ixesha lokuposa: Dec-11-2023