Hydroxypropyl methylcellulose gel ubushyuhe

Hydroxypropylmethylcellulose (HPMC) ni inkomoko ya selile ikoreshwa cyane mu nganda zitandukanye nk'ubuvuzi, ibiryo ndetse no kwisiga.Ni polymer ikora cyane ishobora gukora gel mubihe bimwe, kandi ubushyuhe bwa gel ni umutungo wingenzi.

Ubushyuhe bwa HPMC bivuga ubushyuhe polimeri ihura nicyiciro kuva mubisubizo bikagera kuri leta.Inzira ya gelation yibasiwe nibintu bitandukanye, harimo kwibanda kuri HPMC mugisubizo, kuba hari ibindi bintu, hamwe nibidukikije.

Ubushyuhe bwa gelation ya HPMC bugira ingaruka ku rwego rwo gusimbuza hydroxypropyl na methyl matsinda ku mugongo wa selile.Impamyabumenyi zo hejuru zisimburwa muri rusange zitera ubushyuhe buke.Byongeye kandi, kwibanda kwa HPMC mubisubizo nabyo bigira uruhare runini.Ubushuhe bwinshi muri rusange butera ubushyuhe buke.

Uburyo bwa gelation ya HPMC burimo gushiraho urusobe rwibice bitatu byiminyururu ya polymer binyuze mumashyirahamwe hagati (urugero, guhuza hydrogen).Uru rusobe rugena imiterere yumubiri wa gel, nkubwiza bwimbaraga nimbaraga.

Gusobanukirwa ubushyuhe bwa gelation ya HPMC nibyingenzi mubikorwa bitandukanye.Kurugero, murwego rwa farumasi, nibyingenzi mugutezimbere uburyo bwo gutanga imiti igenzurwa-irekurwa.Ubushyuhe bwa gelation bugena igihe bifata kugirango matelike ya geli ibe mumyanya yumubiri, bityo bikagira ingaruka kumiti irekura.

Mu biribwa no kwisiga, ubushyuhe bwa HPMC ni ngombwa kugenzura ibicuruzwa no guhagarara neza.Ihindura ibintu nkuburyohe, isura nubuzima bwubuzima.HPMC ikoreshwa nkumubyimba cyangwa gelling muri izi nganda.

Tekinike nyinshi zirashobora gukoreshwa mugupima no kugenzura ubushyuhe bwa gel ya HPMC.Itandukaniro rya scanning calorimetry (DSC) hamwe nubushakashatsi bwa rheologiya nuburyo busanzwe bwo kuranga ubushyuhe nubukanishi bwa geles ya HPMC.Muguhindura ibintu nko kwibanda hamwe no kongeramo inyongeramusaruro, abayikora barashobora guhuza ubushyuhe bwimiterere kugirango babone ibisabwa byihariye.

Muri make, hydroxypropyl methylcellulose gel ubushyuhe nibintu byingenzi mubikorwa bitandukanye.Ingaruka zayo kumiterere ya gel ituma iba ibikoresho byingirakamaro mubisabwa kuva muri farumasi kugeza ibiryo ndetse no kwisiga.Gusobanukirwa nibintu bigira ingaruka kubushyuhe bwa HPMC butuma igenzura neza nogutezimbere imikoreshereze yayo muburyo butandukanye.