IHydroxypropyl methylcellulose (HPMC), ekwabizwa ngokuba yi-hypromellose, yipolymer eguquguqukayo esetyenziswa kumashishini ahlukeneyo kubandakanya amayeza, ukutya kunye nokwakha.Yinto ephuma kwi-cellulose eguqulelwe ngokusabela kweekhemikhali ukuphucula iimpawu zayo.Le polymer ibonakaliswe kukunyibilika kwamanzi, i-biocompatibility, kunye nobuchule bokwenza ifilimu.
Ubume beMichiza ye-hydroxypropyl methylcellulose (HPMC):
I-Hydroxypropyl methylcellulose ithathwe kwi-cellulose, i-polysaccharide yendalo efumaneka kwiindonga zeeseli zezityalo.Ubume bekhemikhali be-HPMC bubonakaliswa bubukho be-hydroxypropyl kunye namaqela e-methyl kumqolo we-cellulose.
Umqolo weCellulose:
I-Cellulose yi-polysaccharide ehambelanayo eyenziwe ngeeyunithi ze-glucose ezidityaniswe ngamabhondi e-β-1,4-glycosidic.Iiyunithi eziphindaphindayo zenza amatyathanga amade, aqinileyo abonelela ngesiseko se-HPMC.
I-methyl:
Amaqela e-Methyl (CH3) angeniswa kwi-cellulose backbone ngokusebenzisa i-chemical reaction kunye ne-methanol.Oku kutshintshwa kwandisa i-hydrophobicity ye-polymer, echaphazela ukunyibilika kwayo kunye neempawu zokwenza ifilimu.
IHydroxypropyl:
Amaqela e-Hydroxypropyl (C3H6O) afakwe kwi-cellulose backbone ngokuphendula ngepropylene oxide.La maqela e-hydroxypropyl anegalelo kwi-solubility yamanzi ye-HPMC kunye nefuthe kwi-viscosity yayo.
Iqondo lokuthatha indawo (DS) yamaqela e-methyl kunye ne-hydroxypropyl inokwahluka, echaphazela ukusebenza ngokubanzi kwe-HPMC.I-DS ibhekisa kwi-avareji yenani lababambeleyo kwiyunithi nganye yeglucose kwikhonkco leselulosi.
Ukwenziwa kweHydroxypropyl Methylcellulose (HPMC):
Ukwenziwa kwe-HPMC kubandakanya amanyathelo amaninzi ekhemikhali azisa amaqela e-methyl kunye ne-hydroxypropyl kwi-cellulose backbone.Iimpendulo eziphambili ziquka i-etherification nge-methyl chloride kunye ne-hydroxypropylation ene-propylene oxide.Nantsi isishwankathelo esenziwe lula:
Ukuqaliswa kwe-cellulose:
Inkqubo iqala ngokuvula i-cellulose usebenzisa isiseko, ngokuqhelekileyo i-sodium hydroxide.Eli nyathelo lonyusa ukusebenza kwakhona kwamaqela e-cellulose hydroxyl ukwenzela ukusabela okulandelayo.
I-Methylation:
I-Methyl chloride isetyenziselwa ukwazisa amaqela e-methyl.I-Cellulose iphendula kunye ne-methyl chloride kubukho besiseko, okukhokelela ekutshintshweni kwamaqela e-hydroxyl ngamaqela e-methyl.
impendulo:
Iselulosi-OH+CH3Cl→Iselulosi-OMe+Iselulosi Hydrochloride-OH+CH3Cl→Iselulosi-OMe+HCl
IHydroxypropylation:
Amaqela e-Hydroxypropyl afakwe kwi-cellulose backbone usebenzisa i-propylene oxide.Ukusabela ngokuqhelekileyo kwenzeka kwi-alkaline medium kunye neqondo le-hydroxypropylation lilawulwa ukufezekisa iipropati ezifunwayo.
impendulo:
Iselulosi-OH+C3H6 ioksijini→Iselulosi-O-(CH2CH(OH)CH3)+H2 ioksijini ISelulosi-OH+C3H6O→Iselulosi-O-(CH2CH(OH)CH3)+H2 ioksijini
Ukungathathi hlangothi kunye nokucoca:
Imveliso ebangelwayo ingathathi hlangothi ukususa nayiphi na i-acidic eseleyo okanye i-residus esisiseko.Amanyathelo okucoca afana nokuhlamba kunye nokuhluzwa kwenziwa ukufumana iimveliso ze-HPMC ezikumgangatho ophezulu.
Iimpawu zeMichiza yeHydroxypropyl Methylcellulose (HPMC):
Ukunyibilika:
I-HPMC inyibilika ngokulula emanzini abandayo, kwaye ukunyibilika kungahlengahlengiswa ngokutshintsha iqondo lokuthatha indawo.Amanqanaba aphezulu okutshintsha ngokubanzi akhokelela ekunyibilikeni okwandisiweyo.
Ukwenziwa kwefilimu:
I-HPMC ineempawu ezigqwesileyo zokwenza ifilim, iyenza ilungele usetyenziso olunje ngezogquma zamayeza kunye nokupakishwa kokutya.Ifilimu ephumela ekuhleni kwaye inika umqobo wegesi.
I-Thermal Gelation:
I-Thermal gelation yipropati ekhethekileyo ye-HPMC.I-gel ifom xa ishushu, kwaye amandla e-gel axhomekeke kwizinto ezifana nokugxila kunye nobunzima be-molecular.
Viscosity:
I-viscosity yezisombululo ze-HPMC zichatshazelwa ngumgangatho wokutshintshwa kunye nokugxila.Njenge-thickener, isetyenziswa kakhulu kumashishini ahlukeneyo.
Umsebenzi womphezulu:
I-HPMC ineepropati ezifana ne-surfactant ezinegalelo kubuchule bayo bokubumba kunye nokuzinzisa ekuxutyweni.
Biocompatibility:
I-HPMC ithathwa njenge-biocompatible, iyenza ilungele ukusetyenziswa kumachiza, kubandakanywa nemixube yamachiza alawulwayo.
Usetyenziso lweHydroxypropyl Methylcellulose (HPMC):
iyeza:
I-HPMC idla ngokusetyenziswa njengezibophelelo, iityali zefilim, kunye nokulawulwa kweematriki zokukhululwa kwimixube yamayeza.
melana:
Kwishishini lokwakha, i-HPMC isetyenziswa njenge-arhente yokugcina amanzi kwizinto ezisekelwe kwi-samente, ukuphucula ukusebenza kunye nokunciphisa ulwahlulo lwamanzi.
ishishini lokutya:
I-HPMC isetyenziswa kushishino lokutya njenge-thickener, stabilizer kunye ne-gelling agent.Isetyenziswa rhoqo kwiimveliso ezifana neesosi, isuphu kunye ne-ayisikrimu.
Iimveliso zokhathalelo lomntu:
Izinto zokuthambisa kunye neShishini lokuKhathalela uBuqu Use HPMC isetyenziswa kwiimveliso ezifana neekhrimu kunye nezinto zokuthambisa ngenxa yokuqina kwayo kunye neempawu zokuthambisa.
Iipeyinti kunye neeNqaku:
I-HPMC yongezwa kwiipeyinti kunye neengubo zokwandisa i-viscosity, ukuzinza kunye nokugcinwa kwamanzi.
ukuququmbela:
IHydroxypropyl methylcellulose yipolymer eguquguqukayo enoluhlu olubanzi lwezicelo ngenxa yeempawu zayo ezizodwa zeekhemikhali.Ukwenziwa kwe-HPMC kubandakanya ukuqaliswa kwamaqela e-methyl kunye ne-hydroxypropyl kwi-cellulose backbone, ekhokelela kwi-polymer e-soluble yamanzi kunye ne-biocompatible.Izicelo zayo ezahlukeneyo kumayeza, ulwakhiwo, ukutya kunye nokhathalelo lomntu siqu luqaqambisa ukubaluleka kwayo kumashishini ahlukeneyo.Njengoko uphando luqhubeka, uhlengahlengiso olongezelelekileyo kunye nenkqubela phambili kwitekhnoloji ye-HPMC inokwandisa ukusetyenziswa kwayo kwaye iphucule ukusebenza kwayo kwizicelo ezikhoyo nezisakhulayo.
Ixesha lokuposa: Dec-18-2023