Hydroxypropyl methylcellulose (HPMC), e tsejoang hape e le hypromellose, ke polymer e sebetsang ka mefuta e mengata e sebelisoang liindastering tse fapaneng ho kenyeletsoa tsa meriana, lijo le kaho.Ke ntho e tsoang ho cellulose e fetotsoeng ka karabelo ea lik'hemik'hale ho ntlafatsa thepa ea eona.Polymer ena e khetholloa ka ho qhibiliha ha metsi, biocompatibility, le bokhoni ba ho etsa lifilimi.
Sebopeho sa lik'hemik'hale sa hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose e tsoa ho cellulose, polysaccharide ea tlhaho e fumanehang maboteng a lisele tsa semela.Sebopeho sa lik'hemik'hale sa HPMC se khetholloa ke ho ba teng ha lihlopha tsa hydroxypropyl le methyl mokokotlong oa cellulose.
Cellulose mokokotlo:
Cellulose ke polysaccharide e melang e entsoeng ka liyuniti tsa tsoekere tse hokahantsoeng ke β-1,4-glycosidic bond.Liyuniti tse pheta-phetoang li theha liketane tse telele, tse thata tse fanang ka motheo oa sebopeho sa HPMC.
methyl:
Lihlopha tsa Methyl (CH3) li kenngoa mokokotlong oa cellulose ka karabelo ea lik'hemik'hale ka methanol.Phapang ena e ntlafatsa hydrophobicity ea polymer, e amang ho qhibiliha ha eona le thepa ea ho etsa lifilimi.
Hydroxypropyl:
Lihlopha tsa Hydroxypropyl (C3H6O) li khomaretsoe mokokotlong oa cellulose ka ho arabela ka propylene oxide.Lihlopha tsena tsa hydroxypropyl li kenya letsoho ho solubility ea metsi ea HPMC le ho susumetsa viscosity ea eona.
Tekanyo ea substitution (DS) ea lihlopha tsa methyl le hydroxypropyl e ka fapana, e ama ts'ebetso eohle ea HPMC.DS e bolela palo e tloaelehileng ea lintho tse nkeloang sebaka ka yuniti ea tsoekere ka har'a ketane ea cellulose.
Motsoako oa Hydroxypropyl Methylcellulose (HPMC):
Tšimoloho ea HPMC e kenyelletsa mehato e mengata ea lik'hemik'hale e hlahisang lihlopha tsa methyl le hydroxypropyl mokokotlong oa cellulose.Maikutlo a bohlokoa a kenyelletsa etherification ka methyl chloride le hydroxypropylation ka propylene oxide.Mona ke kakaretso e nolofalitsoeng:
Tšebeliso ea cellulose:
Ts'ebetso e qala ka ho kenya cellulose ho sebelisa setsi, hangata sodium hydroxide.Mohato ona o eketsa ts'ebetso ea lihlopha tsa cellulose hydroxyl bakeng sa karabelo e latelang.
Methylation:
Methyl chloride e sebelisoa ho hlahisa lihlopha tsa methyl.Cellulose e sebetsana le methyl chloride ka pel'a motheo, e bakang phetoho ea lihlopha tsa hydroxyl ka lihlopha tsa methyl.
karabelo:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
Lihlopha tsa Hydroxypropyl li khomaretsoe mokokotlong oa cellulose li sebelisa propylene oxide.Hangata karabelo e etsahala sebakeng sa alkaline mme tekanyo ea hydroxypropylation e laoloa ho finyella thepa e lakatsehang.
karabelo:
Cellulose-OH+C3H6 oxygen→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen
Neutralization le tlhoekiso:
Sehlahisoa se hlahisoang ha se nke lehlakore ho tlosa masala a acidic kapa a motheo.Mehato ea tlhoekiso e kang ho hlatsoa le ho sefa e etsoa ho fumana lihlahisoa tsa boleng bo holimo tsa HPMC.
Lintho tsa Lik'hemik'hale tsa Hydroxypropyl Methylcellulose (HPMC):
Sollubility:
HPMC e qhibiliha habonolo metsing a batang, 'me ho qhibiliha ho ka fetoloa ka ho fetola tekanyo ea ho fetola.Maemo a phahameng a phapanyetso hangata a baka ho qhibiliha ho hoholo.
Moetso oa lifilimi:
HPMC e na le thepa e ntle haholo ea ho etsa lifilimi, e etsa hore e tšoanelehe bakeng sa lits'ebetso tse joalo ka litlolo tsa meriana le ho paka lijo.Filimi e hlahisoang e hlakile ebile e fana ka thibelo ea khase.
Thermal gelation:
Thermal gelation ke thepa e ikhethang ea HPMC.Gel e theha ha e futhumala, 'me matla a gel a itšetlehile ka lintlha tse kang ho tsepamisa mohopolo le boima ba limolek'hule.
Viscosity:
Viscosity ea tharollo ea HPMC e angoa ke tekanyo ea ho nkela sebaka le ho tsepamisa maikutlo.E le motenya, e sebelisoa haholo liindastering tse fapaneng.
Ts'ebetso ea bokaholimo:
HPMC e na le thepa e kang surfactant e tlatsetsang ho emulsifying le ho tsitsisa bokhoni ba ho etsa metsoako.
Biocompatibility:
HPMC e nkuoa e sebetsa ka mokhoa oa biocompatible, e etsa hore e tšoanelehe bakeng sa tšebeliso ea meriana, ho kenyeletsoa le metsoako ea lithethefatsi e laoloang.
Lisebelisoa tsa Hydroxypropyl Methylcellulose (HPMC):
lithethefatsi:
HPMC e atisa ho sebelisoa e le li-binders, li-coatings tsa lifilimi, le li-matrices tsa tokollo tse laoloang mefuteng ea meriana.
mamella:
Ka indasteri ea kaho, HPMC e sebelisoa e le moemeli oa ho boloka metsi ka thepa e thehiloeng ho samente, ho ntlafatsa ts'ebetso le ho fokotsa karohano ea metsi.
indasteri ea lijo:
HPMC e sebelisoa indastering ea lijo joalo ka setei, se tsitsisa le ho etsa li-gelling.Hangata e sebelisoa lihlahisoa tse kang li-sauces, sopho le ice cream.
Lihlahisoa tsa tlhokomelo ea motho ka mong:
Tšebeliso ea Indasteri ea Litlolo le Tlhokomelo ea Motho HPMC e sebelisoa lihlahisoa tse kang litlolo le litlolo ka lebaka la ho tenya le ho etsa emulsifying.
Lipente le Liaparo:
HPMC e eketsoa ho lipente le liphahlo ho eketsa viscosity, botsitso le ho boloka metsi.
ha re phethela:
Hydroxypropyl methylcellulose ke polima e nang le mefuta e mengata e nang le mefuta e mengata ea lisebelisoa ka lebaka la lik'hemik'hale tsa eona tse ikhethang.Tšimoloho ea HPMC e kenyelletsa ho kenngoa ha lihlopha tsa methyl le hydroxypropyl mokokotlong oa selulose, e leng se hlahisang polymer e qhibilihang ka metsing le e lumellanang le biocompatible.Lisebelisoa tsa eona tse fapaneng litlhare, kaho, lijo le tlhokomelo ea motho ka mong li totobatsa bohlokoa ba eona liindastering tse fapaneng.Ha lipatlisiso li ntse li tsoela pele, liphetoho tse ling le tsoelopele ea theknoloji ea HPMC e ka holisa ts'ebeliso ea eona le ho ntlafatsa ts'ebetso ea eona lits'ebetsong tse teng le tse ntseng li hlaha.
Nako ea poso: Dec-18-2023