Hydroxypropyl methylcellulose (HPMC), inozivikanwawo se hypromellose, i polymer inoshandiswa zvakasiyana-siyana inoshandiswa mumaindasitiri akasiyana siyana anosanganisira mishonga, chikafu, uye kuvaka.Iyo cellulose derivative yakagadziridzwa kuburikidza nemakemikari reaction kuti iwedzere zvimiro zvayo.Iyi polymer inoratidzirwa nekunyungudika kwemvura, biocompatibility, uye kugona kugadzira firimu.
Kemikari chimiro chehydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose inotorwa kubva ku cellulose, yakasikwa polysaccharide inowanikwa muchirimwa sero madziro.Iyo kemikari chimiro cheHPMC chinoratidzwa nekuvapo kwehydroxypropyl uye methyl mapoka pane cellulose musana.
Cellulose musana:
Cellulose is linear polysaccharide inoumbwa neglucose units yakabatanidzwa ne β-1,4-glycosidic bonds.Anodzokorora mayunitsi anoumba macheni akareba, akaomarara anopa hwaro hwekuumbwa kweHPMC.
methyl:
Mapoka eMethyl (CH3) anounzwa mumusana we cellulose kuburikidza nemakemikari anoita ne methanol.Iyi inotsiva inosimudzira iyo hydrophobicity yepolymer, inokanganisa kunyungudika kwayo uye firimu-kugadzira zvinhu.
Hydroxypropyl:
Mapoka eHydroxypropyl (C3H6O) akabatanidzwa kumusana we cellulose nekuita nepropylene oxide.Aya mapoka ehydroxypropyl anobatsira mukunyungudika kwemvura kweHPMC uye kupesvedzera viscosity yayo.
Iyo dhigirii yekutsiva (DS) yemethyl uye hydroxypropyl mapoka anogona kusiyana, zvichikanganisa kuita kwese kweHPMC.DS inoreva avhareji yenhamba yezvinotsiva paglucose unit mucheni ye cellulose.
Synthesis yeHydroxypropyl Methylcellulose (HPMC):
Iyo synthesis yeHPMC inosanganisira akati wandei makemikari matanho anounza methyl uye hydroxypropyl mapoka mumusana we cellulose.Mabatiro akakosha anosanganisira etherification ine methyl chloride uye hydroxypropylation ine propylene oxide.Heino mhedziso yakapfava:
Activation ye cellulose:
Maitiro acho anotanga nekumisa cellulose uchishandisa base, kazhinji sodium hydroxide.Iyi nhanho inowedzera reactivity yemapoka e-cellulose hydroxyl kune anotevera maitiro.
Methylation:
Methyl chloride inoshandiswa kuunza methyl mapoka.Cellulose inopindirana nemethyl chloride pamberi penheyo, zvichikonzera kutsiviwa kwemapoka ehydroxyl nemapoka emethyl.
kuita:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
Mapoka eHydroxypropyl akabatanidzwa kumusana we cellulose achishandisa propylene oxide.Maitiro acho anowanzo kuitika mune alkaline svikiro uye dhigirii re hydroxypropylation inodzorwa kuti iwane izvo zvinodiwa.
kuita:
Cellulose-OH+C3H6 oxygen→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen
Neutralization uye kuchenesa:
Chigadzirwa chinoguma hachina kudzoreredzwa kubvisa chero yasara acidic kana basic residues.Matanho ekunatsa akadai sekugeza uye kusefa anoitwa kuti awane zvemhando yepamusoro HPMC zvigadzirwa.
Chemical Properties yeHydroxypropyl Methylcellulose (HPMC):
Solubility:
HPMC inonyungudika zviri nyore mumvura inotonhora, uye solubility inogona kugadziriswa nekuchinja dhigirii rekutsiva.Mazinga ekutsiva epamusoro anowanzo konzera kuwedzera kunyungudika.
Kugadzira firimu:
HPMC ine yakanakisa firimu-yekugadzira zvimiro, ichiita kuti ive yakakodzera kune zvikumbiro senge mishonga yekupotera uye kurongedza chikafu.Iyo firimu inoguma iri pachena uye inopa gasi chipingamupinyi.
Thermal gelation:
Thermal gelation inzvimbo yakasarudzika yeHPMC.Iyo gel inoumba kana ichipisa, uye kusimba kwejeri kunoenderana nezvinhu zvakadai sekufungisisa uye molecular uremu.
Viscosity:
Iyo viscosity yeHPMC mhinduro inobatwa neiyo dhigirii yekutsiva uye yekuisa pfungwa.Seyakakora, inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana.
Chiitiko chepamusoro:
HPMC ine surfactant-sezvivakwa izvo zvinopa kune yayo emulsifying uye kudzikamisa kugona mukuumbwa.
Biocompatibility:
HPMC inoonekwa seyakabatana, ichiita kuti ive yakakodzera kushandiswa mumishonga, kusanganisira inodzorwa-inoburitsa zvinodhaka maumbirwo.
Kushandiswa kweHydroxypropyl Methylcellulose (HPMC):
mushonga:
HPMC inowanzo shandiswa semabhainda, mabhaisikopo emufirimu, uye anodzorwa kuburitsa matrices mukugadzira mishonga.
simudza:
Muindasitiri yekuvaka, HPMC inoshandiswa sechinhu chekuchengetedza mvura mune simende-yakavakirwa zvinhu, kuvandudza kushanda uye kuderedza kupatsanurwa kwemvura.
indasitiri yezvekudya:
HPMC inoshandiswa muindasitiri yechikafu seyakakora, inosimbisa uye gelling agent.Inowanzoshandiswa muzvigadzirwa zvakadai sesosi, soups uye ice cream.
Zvigadzirwa zvekuchengeta wega:
Cosmetics uye Personal Care Indasitiri Shandisa HPMC inoshandiswa muzvigadzirwa zvakaita semafuta uye lotions nekuda kwekukora uye emulsifying zvivakwa.
Paints uye Coatings:
HPMC inowedzerwa kune pendi uye coatings kuwedzera viscosity, kugadzikana uye kuchengetedza mvura.
mukupedzisa:
Hydroxypropyl methylcellulose i polymer inoshanda zvakasiyana-siyana ine huwandu hwakawanda hwemashandisirwo nekuda kwekusiyana kwayo kwemakemikari zvimiro.Iyo synthesis yeHPMC inosanganisira kuunzwa kwemethyl uye hydroxypropyl mapoka mu cellulose musana, zvichikonzera mvura-inonyungudika uye biocompatible polymer.Kushandiswa kwaro kwakasiyana-siyana mumishonga, kuvaka, chikafu uye kutarisirwa kwemunhu kunoratidza kukosha kwayo mumaindasitiri akasiyana.Sezvo tsvagiridzo ichienderera mberi, kumwe kugadziridzwa uye kufambira mberi kweHPMC tekinoroji inogona kuwedzera mashandisiro ayo uye kuwedzera mashandiro ayo mumashandisirwo aripo uye ari kubuda.
Nguva yekutumira: Zvita-18-2023