Hydroxypropyl methylcellulose (HPMC), makwaara dị ka hypromellose, bụ polymer vasatail eji n'ọtụtụ ụlọ ọrụ gụnyere ọgwụ, nri, na ihe owuwu.Ọ bụ ihe nrụpụta cellulose emegharịrị site na mmeghachi omume kemịkalụ iji kwalite njirimara ya.A na-eji polymer a mara site na mmiri solubility, biocompatibility, na ike imepụta ihe nkiri.
Ọdịdị kemịkal nke hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose sitere na cellulose, polysaccharide sitere n'okike nke a na-ahụ na mgbidi cell osisi.Ejiri usoro kemịkalụ nke HPMC mara site na ọnụnọ nke hydroxypropyl na methyl dị n'ọkpụkpụ cellulose.
Ọkpụkpụ cellulose:
Cellulose bụ polysaccharide linear nke mejupụtara nkeji glucose jikọtara ya na njikọ β-1,4-glycosidic.Nkeji ugboro ugboro na-etolite ogologo agbụ siri ike nke na-enye ntọala nhazi maka HPMC.
methyl:
A na-ewebata otu Methyl (CH3) n'ime ọkpụkpụ azụ cellulose site na mmeghachi omume kemịkalụ na methanol.Ngbanwe a na-eme ka hydrophobicity nke polymer dịkwuo mma, na-emetụta ya solubility na ihe ndị na-emepụta ihe nkiri.
Hydroxypropyl:
Otu hydroxypropyl (C3H6O) na-ejikọta ya na ọkpụkpụ azụ cellulose site na mmeghachi omume na propylene oxide.Otu hydroxypropyl ndị a na-enye aka na solubility mmiri nke HPMC ma na-emetụta viscosity ya.
Ogo nke nnọchi (DS) nke otu methyl na hydroxypropyl nwere ike ịdị iche, na-emetụta arụmọrụ HPMC n'ozuzu ya.DS na-ezo aka na nkezi ọnụọgụ nke ihe nnọchi n'otu nkeji glucose na yinye cellulose.
Njikọ nke Hydroxypropyl Methylcellulose (HPMC):
Ngwakọta nke HPMC gụnyere ọtụtụ usoro kemịkalụ na-ewebata otu methyl na hydroxypropyl n'ime ọkpụkpụ azụ cellulose.Mmeghachi omume ndị dị mkpa gụnyere etherification na methyl chloride na hydroxypropylation na propylene oxide.Nke a bụ ntụle dị mfe:
Ntinye nke cellulose:
Usoro na-amalite site na ịgbalite cellulose site na iji isi, na-abụkarị sodium hydroxide.Nzọụkwụ a na-abawanye mmeghachi omume nke otu cellulose hydroxyl maka mmeghachi omume na-esote.
Methylation:
A na-eji Methyl chloride ewebata otu methyl.Cellulose na-emeghachi omume na methyl chloride na ọnụnọ nke isi, na-ebute nnọchi nke otu hydroxyl na otu methyl.
mmeghachi omume:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
Otu hydroxypropyl na-ejikọta ya na ọkpụkpụ azụ cellulose site na iji propylene oxide.Mmeghachi omume na-emekarị na etiti alkaline na ogo nke hydroxypropylation na-achịkwa iji nweta ihe ndị a chọrọ.
mmeghachi omume:
Cellulose-OH+C3H6 oxygen→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O→ Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen
Nnọpụiche na ịdị ọcha:
A na-ewepụ ngwaahịa a na-esi na ya pụta iji wepụ ihe ọ bụla acidic ma ọ bụ ihe fọdụrụnụ.A na-eme usoro nchacha dị ka ịsa na nzacha iji nweta ngwaahịa HPMC dị elu.
Njirimara kemịkalụ nke Hydroxypropyl Methylcellulose (HPMC):
Solubility:
HPMC dị mfe soluble na mmiri oyi, na solubility nwere ike gbanwee site na-agbanwe ogo nke nnọchi.Ọkwa ngbanwe dị elu na-ebutekarị solubility.
Nhazi ihe nkiri:
HPMC nwere ọmarịcha ihe na-emepụta ihe nkiri, na-eme ka ọ dabara maka ngwa dị ka mkpuchi ọgwụ na nkwakọ ngwaahịa nri.Ihe nkiri a na-esi na ya pụta bụ nke ọma ma na-enye ihe mgbochi gas.
Thermal gelation:
Thermal gelation bụ ihe pụrụ iche nke HPMC.A gel na-etolite mgbe ọ na-ekpo ọkụ, na ike nke gel na-adabere n'ihe ndị dị ka ntinye uche na ịdị arọ molecular.
Viscosity:
The viscosity nke HPMC ngwọta na-emetụta ogo nke nnọchi na itinye uche.Dị ka thickener, a na-eji ya eme ihe n'ọtụtụ ụlọ ọrụ dị iche iche.
Ọrụ elu:
HPMC nwere surfactant-dị ka Njirimara na-eme ka emulsifying na stabilizing ike na formulations.
Nkwekọrịta ihe ndị dị ndụ:
A na-ahụta HPMC dị ka ihe na-emekọrịta ihe, na-eme ka ọ dabara maka ojiji na ọgwụ, gụnyere usoro ntọhapụ nke ọgwụ na-achịkwa.
Ngwa nke Hydroxypropyl Methylcellulose (HPMC):
ọgwụ:
A na-ejikarị HPMC eme ihe dị ka ihe na-ekekọta, mkpuchi ihe nkiri, na matrices ntọhapụ a na-achịkwa na usoro ọgwụ.
na-edi:
N'ime ụlọ ọrụ ihe owuwu, a na-eji HPMC eme ihe dị ka onye na-eji mmiri na-eji ciment eme ihe, na-eme ka ọrụ ọrụ dịkwuo mma ma na-ebelata ikewa mmiri.
ụlọ ọrụ nri:
A na-eji HPMC eme ihe na ụlọ ọrụ nri dị ka onye na-agbapụta, stabilizer na onye na-ahụ maka gelling.A na-ejikarị ya eme ihe na ngwaahịa ndị dị ka sauces, ofe na ice cream.
Ngwaahịa nlekọta onwe onye:
A na-eji HPMC eme ihe ịchọ mma na ụlọ ọrụ nlekọta onwe onye na ngwaahịa ndị dị ka ude na lotions n'ihi ihe na-eme ka ọ sie ike na emulsifying.
Agba na mkpuchi:
A na-agbakwunye HPMC na agba na mkpuchi iji mee ka viscosity dịkwuo elu, nkwụsi ike na njide mmiri.
na ngwụcha:
Hydroxypropyl methylcellulose bụ polymer vasatail nwere ọtụtụ ngwa n'ihi njirimara kemịkal pụrụ iche.Ngwakọta nke HPMC na-agụnye iwebata methyl na hydroxypropyl dị iche iche n'ime ọkpụkpụ azụ cellulose, na-eme ka mmiri na-edozi mmiri na nke na-ejikọta ya na polymer.Ngwa ya dị iche iche na ọgwụ, ihe owuwu, nri na nlekọta onwe onye gosipụtara mkpa ọ dị na ụlọ ọrụ dị iche iche.Ka nyocha na-aga n'ihu, mgbanwe ndị ọzọ na ọganihu na teknụzụ HPMC nwere ike gbasaa uru ya ma kwalite arụmọrụ ya na ngwa ndị dị adị na ndị na-apụta.
Oge nzipu: Dec-18-2023