ʻO Hydroxypropyl methylcellulose (HPMC), i kapa ʻia ʻo hypromellose, he polymer versatile i hoʻohana ʻia i nā ʻoihana like ʻole me nā lāʻau lapaʻau, meaʻai, a me ke kūkulu ʻana.He cellulose derivative ia i hoʻololi ʻia ma o ka hopena kemika e hoʻonui ai i kāna mau waiwai.Hōʻike ʻia kēia polymer e ka solubility wai, biocompatibility, a me ka hiki ke hana kiʻiʻoniʻoni.
ʻO ke kinona o ka hydroxypropyl methylcellulose (HPMC):
Loaʻa ka Hydroxypropyl methylcellulose mai ka cellulose, he polysaccharide maoli i loaʻa i loko o nā paia o nā mea kanu.Hōʻike ʻia ke ʻano kemika o HPMC e ka hiki ʻana o nā hui hydroxypropyl a me methyl ma ka iwi kuamoʻo cellulose.
iwi kuamoʻo cellulose:
ʻO Cellulose kahi polysaccharide laina i haku ʻia me nā ʻāpana glucose i hoʻopili ʻia e nā paʻa β-1,4-glycosidic.Hoʻokumu nā ʻāpana hana hou i nā kaulahao lōʻihi a paʻa e hāʻawi i ke kumu hana no HPMC.
methyl:
Hoʻokomo ʻia nā pūʻulu Methyl (CH3) i loko o ka iwi kuamoʻo cellulose ma o ka hopena kemika me ka methanol.Hoʻonui kēia hoʻololi i ka hydrophobicity o ka polymer, e pili ana i kona solubility a me nā waiwai hana kiʻiʻoniʻoni.
Hydroxypropyl:
Hoʻopili ʻia nā pūʻulu hydroxypropyl (C3H6O) i ka iwi kuamoʻo cellulose ma o ka hoʻopili ʻana me ka propylene oxide.Hāʻawi kēia mau pūʻulu hydroxypropyl i ka hoʻoheheʻe wai o HPMC a hoʻololi i kona viscosity.
Hiki ke ʻokoʻa ke degere o ka hoʻololi ʻana (DS) o nā hui methyl a me hydroxypropyl, e pili ana i ka hana holoʻokoʻa o HPMC.Hōʻike ʻo DS i ka helu awelika o nā mea pani no kēlā me kēia ʻāpana glucose i ke kaulahao cellulose.
Hoʻohui ʻia o Hydroxypropyl Methylcellulose (HPMC):
ʻO ka synthesis o HPMC e pili ana i kekahi mau hana kemika e hoʻokomo i nā pūʻulu methyl a me hydroxypropyl i loko o ka iwi kuamoʻo cellulose.ʻO nā hopena koʻikoʻi ka etherification me ka methyl chloride a me ka hydroxypropylation me ka propylene oxide.Eia kahi ʻike maʻalahi:
Hoʻoulu ʻia o ka cellulose:
Hoʻomaka ke kaʻina hana ma ka hoʻoulu ʻana i ka cellulose me ka hoʻohana ʻana i kahi kumu, maʻamau ka sodium hydroxide.Hoʻonui kēia ʻanuʻu i ka reactivity o nā pūʻulu cellulose hydroxyl no nā hopena hope.
Methylation:
Hoʻohana ʻia ka Methyl chloride e hoʻolauna i nā hui methyl.Hoʻopili ʻo Cellulose me ka methyl chloride i mua o kahi kumu, ka hopena o ka hoʻololi ʻana o nā pūʻulu hydroxyl me nā hui methyl.
pane:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
Hoʻopili ʻia nā hui hydroxypropyl i ka iwi kuamoʻo cellulose me ka propylene oxide.Hana ʻia ka hopena ma kahi ʻano alkaline a mālama ʻia ke degere o ka hydroxypropylation e hoʻokō i nā waiwai i makemake ʻia.
pane:
Cellulose-OH+C3H6 oxygen→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen
Neutralization a me ka hoʻomaʻemaʻe:
Hoʻokuʻu ʻia ka huahana e hoʻoneʻe i nā koena acidic a i ʻole nā koena kumu.Hana ʻia nā hana hoʻomaʻemaʻe e like me ka holoi ʻana a me ka kānana no ka loaʻa ʻana o nā huahana HPMC kiʻekiʻe.
Nā Pono Kemika o Hydroxypropyl Methylcellulose (HPMC):
Hiki ke hoʻoheheʻe:
Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai anuanu, a hiki ke hoʻololi ʻia ka solubility ma o ka hoʻololi ʻana i ke ʻano o ka hoʻololi ʻana.ʻO nā pae hoʻololi kiʻekiʻe ka hopena i ka hoʻonui ʻana i ka solubility.
Hoʻokumu kiʻiʻoniʻoni:
Loaʻa i ka HPMC nā waiwai hana kiʻiʻoniʻoni maikaʻi loa, kūpono ia no nā noi e like me nā pale lāʻau lapaʻau a me ka hoʻopili meaʻai.ʻO ke kiʻiʻoniʻoni i loaʻa he aniani a hāʻawi i kahi pale kinoea.
ʻO ka wai wela:
He waiwai kū hoʻokahi o ka HPMC.Hoʻokumu ʻia kahi gel i ka wā i wela ai, a ʻo ka ikaika o ka gel e pili ana i nā mea e like me ka noʻonoʻo a me ke kaumaha mole.
viscosity:
Hoʻopili ʻia ka viscosity o nā hoʻonā HPMC e ke kiʻekiʻe o ka hoʻololi a me ka noʻonoʻo.Ma keʻano he mānoanoa, hoʻohana nuiʻia i nāʻoihana likeʻole.
Hana i luna:
Loaʻa i ka HPMC nā waiwai e like me ka surfactant e hāʻawi i kāna emulsifying a me ka hoʻopaʻa ʻana i nā mana i nā formulations.
Biocompatibility:
Manaʻo ʻia ʻo HPMC he biocompatible, no laila kūpono ia no ka hoʻohana ʻana i nā lāʻau lapaʻau, me nā ʻano lāʻau lapaʻau hoʻokuʻu ʻia.
Nā noi no ka Hydroxypropyl Methylcellulose (HPMC):
lāʻau lapaʻau:
Hoʻohana mau ʻia ʻo HPMC ma ke ʻano he mea hoʻopaʻa, nā uhi kiʻiʻoniʻoni, a me nā matrices hoʻokuʻu i hoʻomalu ʻia i loko o nā ʻano lāʻau lapaʻau.
kau i luna:
I ka ʻoihana kūkulu, hoʻohana ʻia ʻo HPMC ma ke ʻano he mea mālama wai i nā mea sima, hoʻomaikaʻi i ka hana a hoʻemi i ka hoʻokaʻawale wai.
ʻoihana meaʻai:
Hoʻohana ʻia ʻo HPMC i ka ʻoihana meaʻai e like me ka mānoanoa, stabilizer a me ka gelling agent.Hoʻohana pinepine ʻia i nā huahana e like me nā ʻuala, nā soup a me ka ice cream.
Nā huahana mālama pilikino:
Hoʻohana ʻia nā mea hoʻonaninani a me nā ʻoihana mālama pilikino HPMC i nā huahana e like me ka creams a me nā lotions ma muli o kona mānoanoa a me ka emulsifying waiwai.
Nā pena a me nā pena:
Hoʻohui ʻia ka HPMC i nā pena a me nā uhi e hoʻonui i ka viscosity, kūpaʻa a me ka paʻa ʻana o ka wai.
i ka hopena:
ʻO ka Hydroxypropyl methylcellulose kahi polymer versatile me kahi ākea o nā noi ma muli o kāna mau waiwai kemika.Hoʻokomo ka synthesis o HPMC i ka hoʻokomo ʻana i nā pūʻulu methyl a me hydroxypropyl i loko o ka iwi kuamoʻo cellulose, ka hopena i kahi polymer hiki ke hoʻoheheʻe wai a biocompatible.ʻO kāna mau noi like ʻole i ka lāʻau lapaʻau, ke kūkulu ʻana, ka meaʻai a me ka mālama pilikino e hōʻike ana i kona koʻikoʻi i nā ʻoihana like ʻole.Ke hoʻomau nei ka noiʻi ʻana, hiki i nā hoʻololi hou a me nā holomua o ka ʻenehana HPMC ke hoʻonui i kāna pono a hoʻonui i kāna hana i nā noi e kū nei a e kū nei.
Ka manawa hoʻouna: Dec-18-2023