Hydroxypropyl methylcellulose (HPMC), tseem hu ua hypromellose, yog ntau yam polymer siv nyob rau hauv ntau yam lag luam xws li tshuaj, khoom noj khoom haus, thiab kev tsim kho.Nws yog ib qho cellulose derivative hloov kho los ntawm cov tshuaj tiv thaiv los txhim kho nws cov khoom.Cov polymer no yog tus cwj pwm los ntawm dej solubility, biocompatibility, thiab muaj peev xwm ua yeeb yaj kiab.
Cov qauv tshuaj ntawm hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose yog muab los ntawm cellulose, ib tug natural polysaccharide pom nyob rau hauv cov nroj tsuag cell phab ntsa.Cov qauv tshuaj ntawm HPMC yog tus cwj pwm los ntawm kev muaj hydroxypropyl thiab methyl pawg ntawm cov pob txha cellulose.
Cellulose qaum:
Cellulose yog linear polysaccharide uas muaj cov piam thaj txuas los ntawm β-1,4-glycosidic bonds.Repeating units tsim ntev, nruj chains uas muab cov qauv hauv paus rau HPMC.
methyl:
Methyl pawg (CH3) tau nkag mus rau hauv cov pob txha cellulose los ntawm cov tshuaj tiv thaiv nrog methanol.Qhov kev hloov pauv no txhim kho cov hydrophobicity ntawm cov polymer, cuam tshuam rau nws cov solubility thiab kev ua yeeb yaj kiab.
Hydroxypropyl:
Hydroxypropyl pawg (C3H6O) yog txuas nrog cellulose caj qaum los ntawm cov tshuaj tiv thaiv nrog propylene oxide.Cov pab pawg hydroxypropyl no pab txhawb rau cov dej solubility ntawm HPMC thiab cuam tshuam nws cov viscosity.
Qib ntawm kev hloov pauv (DS) ntawm pawg methyl thiab hydroxypropyl tuaj yeem sib txawv, cuam tshuam rau tag nrho kev ua haujlwm ntawm HPMC.DS hais txog qhov nruab nrab ntawm cov neeg hloov pauv hauv ib chav tsev piam thaj hauv cov saw cellulose.
Synthesis ntawm Hydroxypropyl Methylcellulose (HPMC):
Lub synthesis ntawm HPMC suav nrog ntau cov kauj ruam tshuaj uas qhia methyl thiab hydroxypropyl pawg mus rau hauv cov pob txha cellulose.Cov tshuaj tiv thaiv tseem ceeb suav nrog etherification nrog methyl chloride thiab hydroxypropylation nrog propylene oxide.Nov yog ib qho yooj yim piav qhia:
Activation ntawm cellulose:
Cov txheej txheem pib los ntawm kev ua kom cov cellulose siv lub hauv paus, feem ntau yog sodium hydroxide.Cov kauj ruam no ua rau kom cov reactivity ntawm cellulose hydroxyl pawg rau cov kev tshwm sim tom ntej.
Methylation:
Methyl chloride yog siv los qhia methyl pawg.Cellulose reacts nrog methyl chloride nyob rau hauv lub xub ntiag ntawm lub hauv paus, uas ua rau hloov cov hydroxyl pawg nrog methyl pawg.
tshuaj tiv thaiv:
Cellulose-OH + CH3Cl → Cellulose-Ome + Cellulose Hydrochloride-OH + CH3Cl → Cellulose-Ome + HCl
Hydroxypropylation:
Hydroxypropyl pawg yog txuas nrog cov pob txha cellulose siv propylene oxide.Cov tshuaj tiv thaiv feem ntau tshwm sim hauv qhov nruab nrab alkaline thiab qib ntawm hydroxypropylation yog tswj kom ua tiav cov khoom xav tau.
tshuaj tiv thaiv:
Cellulose-OH + C3H6 oxygen → Cellulose-O-(CH2CH(OH)CH3) + H2 oxygen Cellulose-OH + C3H6O → Cellulose-O-(CH2CH(OH)CH3) + H2 oxygen
Neutralization thiab purification:
Cov khoom uas tau tshwm sim yog neutralized kom tshem tawm cov kua qaub lossis cov seem tseem ceeb.Cov kauj ruam ua kom huv xws li ntxuav thiab lim tau ua kom tau txais cov khoom zoo HPMC.
Chemical Properties of Hydroxypropyl Methylcellulose (HPMC):
Solubility:
HPMC yog yooj yim soluble nyob rau hauv dej txias, thiab solubility tuaj yeem hloov kho los ntawm kev hloov pauv qib.Kev hloov pauv siab dua feem ntau ua rau muaj kev solubility ntxiv.
Zaj duab xis tsim:
HPMC muaj cov cuab yeej ua yeeb yaj kiab zoo heev, ua rau nws tsim nyog rau cov ntawv thov xws li cov tshuaj pleev xim thiab ntim khoom noj.Cov yeeb yaj kiab uas tau tshwm sim yog pob tshab thiab muab cov khoom thaiv roj.
Thermal gelation:
Thermal gelation yog ib yam khoom tshwj xeeb ntawm HPMC.Ib daim ntawv gel tsim thaum rhuab, thiab lub zog ntawm cov gel nyob ntawm yam xws li concentration thiab molecular hnyav.
viscosity:
Lub viscosity ntawm HPMC cov kev daws teeb meem yog cuam tshuam los ntawm qib ntawm kev hloov pauv thiab concentration.Raws li ib tug thickener, nws yog dav siv nyob rau hauv ntau yam lag luam.
Kev ua haujlwm saum npoo:
HPMC muaj cov khoom zoo li surfactant uas pab txhawb rau nws cov emulsifying thiab stabilizing peev xwm hauv formulations.
Biocompatibility:
HPMC raug suav hais tias yog biocompatible, ua rau nws tsim nyog rau kev siv tshuaj, suav nrog kev tswj-tso tshuaj formulations.
Kev siv ntawm Hydroxypropyl Methylcellulose (HPMC):
tshuaj:
HPMC feem ntau yog siv los ua binders, zaj duab xis txheej, thiab tswj kev tso tawm matrices hauv cov tshuaj formulations.
muab tso rau:
Hauv kev tsim kho kev lag luam, HPMC yog siv los ua tus neeg saib xyuas dej hauv cov khoom siv cement, txhim kho kev ua haujlwm thiab txo cov dej sib cais.
kev lag luam zaub mov:
HPMC yog siv rau hauv kev lag luam khoom noj khoom haus ua cov thickener, stabilizer thiab gelling tus neeg sawv cev.Nws yog feem ntau siv rau hauv cov khoom xws li kua ntses, kua zaub thiab ice cream.
Cov khoom siv tu tus kheej:
Tshuaj pleev ib ce thiab Kev Kho Tus Kheej Kev Lag Luam Siv HPMC yog siv rau hauv cov khoom xws li cream thiab tshuaj pleev ib ce vim nws thickening thiab emulsifying zog.
Paints thiab Coatings:
HPMC tau ntxiv rau cov xim thiab cov coatings kom viscosity, stability thiab dej tuav.
nyob rau hauv xaus:
Hydroxypropyl methylcellulose yog ntau yam polymer nrog ntau yam kev siv vim nws cov khoom siv tshuaj lom neeg tshwj xeeb.Lub synthesis ntawm HPMC suav nrog kev qhia txog methyl thiab hydroxypropyl pawg mus rau hauv cov pob txha cellulose, uas ua rau muaj dej-soluble thiab biocompatible polymer.Nws cov ntawv thov sib txawv hauv kev siv tshuaj, kev tsim kho, khoom noj thiab kev saib xyuas tus kheej qhia nws qhov tseem ceeb hauv ntau yam kev lag luam.Raws li kev tshawb fawb txuas ntxiv, kev hloov kho ntxiv thiab kev nce qib hauv HPMC thev naus laus zis tuaj yeem nthuav dav nws cov txiaj ntsig thiab txhim kho nws cov kev ua tau zoo hauv cov ntawv thov uas twb muaj lawm thiab tawm tshiab.
Post lub sij hawm: Dec-18-2023