Hydroxypropyl methylcellulose (HPMC), wanda kuma aka sani da hypromellose, wani nau'in polymer ne da aka yi amfani da shi a cikin masana'antu iri-iri ciki har da magunguna, abinci, da gine-gine.Samfurin cellulose ne wanda aka gyara ta hanyar sinadarai don haɓaka kaddarorinsa.Wannan polymer yana da alaƙa da narkewar ruwa, daidaituwar halitta, da damar yin fim.
Tsarin sinadaran hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose an samo shi daga cellulose, polysaccharide na halitta da ake samu a ganuwar tantanin halitta.Tsarin sinadarai na HPMC yana da alaƙa da kasancewar hydroxypropyl da ƙungiyoyin methyl akan kashin bayan cellulose.
Kashin baya na Cellulose:
Cellulose shine polysaccharide madaidaiciya wanda ya ƙunshi raka'o'in glucose wanda ke da alaƙa da haɗin β-1,4-glycosidic.Maimaita raka'a suna samar da dogayen sarƙoƙi masu tsayi waɗanda ke ba da tushen tsarin HPMC.
methyl:
Ana shigar da ƙungiyoyin methyl (CH3) a cikin kashin bayan cellulose ta hanyar sinadarai tare da methanol.Wannan musanya yana haɓaka haɓakar hydrophobicity na polymer, yana haifar da solubility da abubuwan ƙirƙirar fim.
Hydroxypropyl:
Ƙungiyoyin Hydroxypropyl (C3H6O) suna haɗe zuwa kashin bayan cellulose ta hanyar amsawa tare da propylene oxide.Waɗannan ƙungiyoyin hydroxypropyl suna ba da gudummawa ga solubility na ruwa na HPMC kuma suna tasiri danko.
Matsayin maye gurbin (DS) na ƙungiyoyin methyl da hydroxypropyl na iya bambanta, yana shafar aikin gaba ɗaya na HPMC.DS yana nufin matsakaicin adadin masu maye gurbin kowane rukunin glucose a cikin sarkar cellulose.
Haɗin gwiwar Hydroxypropyl Methylcellulose (HPMC):
Haɗin HPMC ya ƙunshi matakan sinadarai da yawa waɗanda ke gabatar da ƙungiyoyin methyl da hydroxypropyl a cikin kashin bayan cellulose.Babban halayen sun haɗa da etherification tare da methyl chloride da hydroxypropylation tare da propylene oxide.Anan ga taƙaitaccen bayani:
Kunna cellulose:
Tsarin yana farawa ta hanyar kunna cellulose ta amfani da tushe, yawanci sodium hydroxide.Wannan matakin yana ƙara haɓakawa na ƙungiyoyin cellulose hydroxyl don halayen masu zuwa.
Methylation:
Ana amfani da Methyl chloride don gabatar da ƙungiyoyin methyl.Cellulose yana amsawa tare da methyl chloride a gaban tushe, yana haifar da maye gurbin kungiyoyin hydroxyl tare da kungiyoyin methyl.
amsa:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
Ƙungiyoyin Hydroxypropyl suna haɗe zuwa kashin bayan cellulose ta amfani da propylene oxide.Halin yawanci yana faruwa a cikin matsakaici na alkaline kuma ana sarrafa matakin hydroxypropylation don cimma abubuwan da ake so.
amsa:
Cellulose-OH+C3H6 oxygen→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O →Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen
Neuralization da tsarkakewa:
Samfurin da aka samu an ware shi don cire duk wani abu da ya rage na acidic ko na asali.Matakan tsarkakewa kamar wanka da tacewa ana yin su don samun samfuran HPMC masu inganci.
Abubuwan Sinadarai na Hydroxypropyl Methylcellulose (HPMC):
Solubility:
HPMC yana da sauƙin narkewa a cikin ruwan sanyi, kuma ana iya daidaita mai narkewa ta hanyar canza matakin maye gurbin.Matakan musanya mafi girma gabaɗaya yana haifar da ƙara narkewa.
Samuwar fim:
HPMC yana da kyawawan kaddarorin samar da fina-finai, yana sa ya dace da aikace-aikace irin su suturar magunguna da kayan abinci.Fim ɗin da aka samu yana da gaskiya kuma yana ba da shingen gas.
Thermal gelation:
Thermal gelation ne na musamman na HPMC.Gel yana samar da lokacin zafi, kuma ƙarfin gel ɗin ya dogara da dalilai irin su maida hankali da nauyin kwayoyin halitta.
Dankowa:
Matsakaicin madaidaicin mafita na HPMC yana shafar matakin maye gurbin da maida hankali.A matsayin mai kauri, ana amfani da shi sosai a masana'antu daban-daban.
Ayyukan saman:
HPMC yana da kaddarorin surfactant-kamar waɗanda ke ba da gudummawa ga haɓakar haɓakawa da haɓaka ƙarfin su a cikin abubuwan samarwa.
Daidaituwar halittu:
Ana ɗaukar HPMC a matsayin mai jituwa, yana mai da shi dacewa don amfani a cikin magunguna, gami da tsarin sarrafa magunguna.
Aikace-aikace na Hydroxypropyl Methylcellulose (HPMC):
magani:
HPMC ana yawan amfani dashi azaman masu ɗaure, suturar fim, da matrices na sakin sarrafawa a cikin ƙirar magunguna.
sanya:
A cikin masana'antar gine-gine, ana amfani da HPMC a matsayin wakili mai riƙe da ruwa a cikin kayan da aka gina da siminti, inganta aikin aiki da rage rarraba ruwa.
masana'antar abinci:
Ana amfani da HPMC a cikin masana'antar abinci azaman mai kauri, mai daidaitawa da wakili na gelling.Ana amfani da shi sau da yawa a cikin samfurori irin su miya, miya da ice cream.
Kayayyakin kula da mutum:
Kayan shafawa da Masana'antar Kulawa ta Keɓaɓɓu Ana amfani da HPMC a cikin samfura kamar su creams da lotions saboda kauri da abubuwan haɓakawa.
Paints da Rubutun:
Ana ƙara HPMC zuwa fenti da sutura don ƙara danko, kwanciyar hankali da riƙe ruwa.
a ƙarshe:
Hydroxypropyl methylcellulose wani nau'in polymer ne tare da aikace-aikace iri-iri saboda abubuwan sinadarai na musamman.Haɗin HPMC ya haɗa da shigar da ƙungiyoyin methyl da hydroxypropyl a cikin kashin baya na cellulose, wanda ya haifar da polymer mai narkewa da ruwa.Aikace-aikacen sa daban-daban a cikin magunguna, gini, abinci da kulawa na sirri suna nuna mahimmancinsa a masana'antu daban-daban.Yayin da bincike ya ci gaba, ƙarin gyare-gyare da ci gaba a fasahar HPMC na iya faɗaɗa amfanin sa da haɓaka aikin sa a cikin aikace-aikacen da ke gudana da masu tasowa.
Lokacin aikawa: Dec-18-2023