Hydroxypropyl methylcellulose (HPMC), e taʻua foi o le hypromellose, o se polymer faʻaaogaina i le tele o alamanuia e aofia ai vailaʻau, meaʻai, ma le fausiaina.O se mea e maua mai i le cellulose ua suia e ala i se gaioiga fa'a-kemikolo e fa'aleleia ai ona meatotino.O lenei polymer o loʻo faʻaalia i le solubility vai, biocompatibility, ma le mafai ona fai ata.
Fa'asologa o vaila'au o le hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose e maua mai i le cellulose, o se polysaccharide masani e maua i totonu o puipui o laau.O le vailaʻau vailaʻau o le HPMC o loʻo faʻaalia i le i ai o le hydroxypropyl ma le methyl vaega i luga o le cellulose backbone.
Cellulose ivi tua:
O le Cellulose o se polysaccharide laina e fausia i iunite kulukose e fesoʻotaʻi i fusi β-1,4-glycosidic.O iunite fa'asolosolo e fai ai filifili uumi, ma'a'a e maua ai le fa'avae fa'avae mo HPMC.
methyl:
O vaega o le Methyl (CH3) e fa'afeiloa'i i totonu ole ponaivi o le cellulose e ala i se fa'a'avega fa'ama'i ma le methanol.O lenei suiga e faʻaleleia ai le hydrophobicity o le polymer, e aʻafia ai lona solubility ma mea e fai ai ata.
Hydroxypropyl:
O vaega hydroxypropyl (C3H6O) o lo'o fa'apipi'i i le ivi pito i tua o le cellulose e ala i le tali atu i le propylene oxide.O nei vaega o le hydroxypropyl e saofagā i le vai soluble o le HPMC ma a'afia ai lona viscosity.
Ole tikeri ole sui (DS) ole vaega ole methyl ma le hydroxypropyl e ono fesuisuiai, e aafia ai le faatinoga atoa ole HPMC.O le DS o lo'o fa'atatau i le averesi o numera o mea e suitulaga i le kulukose i totonu o le filifili cellulose.
Fa'asologa ole Hydroxypropyl Methylcellulose (HPMC):
O le tu'ufa'atasiga o le HPMC e aofia ai le tele o la'asaga vaila'au e fa'aofia ai vaega methyl ma hydroxypropyl i totonu ole ponaivi o le cellulose.O gaioiga autu e aofia ai le faʻamaʻiina ma le methyl chloride ma le hydroxypropylation ma le propylene oxide.O se fa'amatalaga faigofie:
Fa'agaoioia ole cellulose:
O le faagasologa e amata i le faʻagaoioia o le cellulose e faʻaaoga ai se faʻavae, masani ole sodium hydroxide.O lenei laasaga e faʻateleina ai le gaioiga o vaega o le cellulose hydroxyl mo gaioiga mulimuli ane.
Methylation:
Methyl chloride e faʻaaogaina e faʻafeiloaʻi ai vaega methyl.E tali atu le cellulose ma le methyl chloride i le i ai o se faavae, e mafua ai le suia o vaega hydroxyl ma vaega methyl.
tali:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
O vaega hydroxypropyl o lo'o fa'apipi'i i le ivi ivi o le cellulose e fa'aaoga ai le propylene oxide.O le tali e masani lava ona tupu i se ala alkaline ma o le tikeri o le hydroxypropylation e pulea e ausia ai mea e manaʻomia.
tali:
Selulosa-OH+C3H6 okesene→Selulose-O-(CH2CH(OH)CH3)+H2 okesene Selulosa-OH+C3H6O→Selulose-O-(CH2CH(OH)CH3)+H2 okesene
Neutralization ma le fa'amamāina:
O le oloa e maua e fa'apa'u'ese e aveese ai so'o se toega oona po'o toega fa'avae.Laasaga o le fa'amamāina e pei o le fufuluina ma le fa'amama e fa'atino ina ia maua ai oloa maualuga a le HPMC.
Meatotino Vailaau o le Hydroxypropyl Methylcellulose (HPMC):
Solubility:
HPMC e faigofie ona solu i le vai malulu, ma le solubility e mafai ona fetuutuunai e ala i le suia o le tikeri o le suitulaga.Ole maualuga ole tulaga e suitulaga e masani ona maua ai le fa'ateleina ole solubility.
Fausia ata tifaga:
O le HPMC o lo'o iai ni mea e sili ona lelei e fai ai ata tifaga, e talafeagai mo fa'aoga e pei o vaila'au fa'alavalava ma mea'ai afifi.O le ata tifaga e maua e manino ma maua ai se pa puipui kesi.
Fa'avela vevela:
Gelation vevela o se meatotino tulaga ese a le HPMC.E fai se gel pe a vevela, ma o le malosi o le gel e faʻalagolago i mea e pei o le faʻamalosi ma le mamafa mole.
Viscosity:
O le viscosity o vaifofo HPMC e a'afia i le maualuga o le suitulaga ma le fa'atonuga.I le avea ai o se mafiafia, e faʻaaogaina lautele i pisinisi eseese.
Gaoioiga i luga:
O le HPMC o lo'o i ai mea e pei o le surfactant e saofagā i lona emulsifying ma fa'amautu gafatia i fa'asologa.
Biocompatibility:
O le HPMC e manatu e biocompatible, e talafeagai mo le fa'aogaina i vaila'au, e aofia ai fa'atonuga-fa'asa'olotoga fa'amala'au.
Fa'aaogāga ole Hydroxypropyl Methylcellulose (HPMC):
fualaau faasaina:
O le HPMC e masani ona faʻaaogaina e fai ma fusi, faʻapipiʻi ata, ma matrices faʻasaʻo faʻatonutonu i faʻasologa o vailaʻau.
tuu i luga:
I totonu o fale faufale, o loʻo faʻaaogaina le HPMC e fai ma sui o le vai i mea faʻavae sima, faʻaleleia le faʻaogaina ma faʻaitiitia ai le vavaeeseina o vai.
alamanuia taumafa:
O le HPMC e faʻaaogaina i le alamanuia o meaʻai e avea o se mafiafia, faʻamautu ma gelling agent.E masani ona faʻaaogaina i oloa e pei o sosi, sou ma aisakulimi.
oloa tau tausiga a le tagata lava ia:
Cosmetics and Personal Care Industry Use HPMC e fa'aaogaina i oloa e pei o kulimi ma lotion ona o lona mafiafia ma emulsifying meatotino.
Vali ma Fa'alava:
E fa'aopoopo le HPMC i vali ma fa'alavalava e fa'ateleina ai le viscosity, mautu ma le fa'atumauina o le vai.
i le faaiuga:
Hydroxypropyl methylcellulose o se polymer versatile ma le tele o faʻaoga faʻaoga ona o ona mea faʻapitoa faʻamaʻi.O le tu'ufa'atasiga o le HPMC e aofia ai le fa'aofiina o vaega o le methyl ma le hydroxypropyl i totonu o le cellulose backbone, ma maua ai se polymer e mafai ona solu vai ma biocompatible.O ona fa'aoga eseese i vaila'au, faufale, mea'ai ma tausiga a le tagata lava ia e fa'ailoa ai lona taua i pisinisi eseese.A'o fa'aauau su'esu'ega, e mafai ona fa'alautele atili le fa'aogaina ma le fa'aleleia atili o le fa'aogaina o tekonolosi HPMC ma fa'aleleia atili ai lona fa'atinoga i fa'aoga o lo'o iai nei ma fa'agasolo.
Taimi meli: Tes-18-2023