Hydroxypropyl methylcellulose (HPMC), oo sidoo kale loo yaqaano hypromellose, waa polymer-ka badan ee loo isticmaalo warshado kala duwan oo ay ku jiraan dawooyinka, cuntada, iyo dhismaha.Waa ka-soo-saar cellulose oo lagu beddelay fal-celin kiimiko si kor loogu qaado hantideeda.polymer-kan waxa lagu gartaa milmi-biyoodka, isqabqabsiga noolaha, iyo awoodaha samaynta filimada.
Qaab dhismeedka kiimikada ee hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose waxaa laga soo qaatay cellulose, polysaccharide dabiici ah oo laga helo gidaarada unugyada dhirta.Qaab dhismeedka kiimikada ee HPMC waxaa lagu gartaa joogitaanka hydroxypropyl iyo kooxaha methyl ee laf dhabarta cellulose.
Laf-dhabarka Cellulose:
Cellulose waa polysaccharide toosan oo ka kooban unugyo gulukoos oo ku xiran β-1,4-glycosidic bonds.Unugyada soo noqnoqda waxay sameeyaan silsilado dhaadheer oo adag oo bixiya aasaaska qaabdhismeedka HPMC.
methyl:
Kooxaha Methyl (CH3) waxaa lagu soo geliyaa laf dhabarta cellulose iyada oo loo marayo falcelin kiimiko ah oo leh methanol.Beddelkaani wuxuu kor u qaadayaa hydrophobicity-ka polymer-ka, taas oo saameynaysa milanka iyo sifooyinka filimada.
Hydroxypropyl:
Kooxaha Hydroxypropyl (C3H6O) waxay ku dheggan yihiin laf-dhabarka cellulose iyagoo ka falcelinaya propylene oxide.Kooxahan hydroxypropyl waxay gacan ka geystaan milanka biyaha ee HPMC waxayna saameeyaan viscosity-keeda.
Heerka beddelka (DS) ee kooxaha methyl iyo hydroxypropyl way kala duwanaan kartaa, taas oo saamaynaysa waxqabadka guud ee HPMC.DS waxa ay tilmaamaysaa celceliska tirada beddelka halbeegga gulukoosta ee silsiladda cellulose.
Isku dhafka Hydroxypropyl Methylcellulose (HPMC):
Isku-dubaridka HPMC waxay ku lug leedahay dhowr tillaabo kiimiko ah oo soo bandhigaya kooxaha methyl iyo hydroxypropyl ee laf dhabarta cellulose.Dareen-celinta muhiimka ah waxaa ka mid ah etherification leh methyl chloride iyo hydroxypropylation leh propylene oxide.Halkan waxaa ah dulmar la fududeeyay:
Firfircoonida cellulose:
Nidaamku wuxuu ku bilaabmayaa in la dhaqaajiyo cellulose iyada oo la adeegsanayo saldhig, badiyaa sodium hydroxide.Talaabadani waxay kordhinaysaa falcelinta kooxaha cellulose hydroxyl ee falcelinta danbe.
Methylation:
Methyl chloride waxaa loo isticmaalaa in lagu soo bandhigo kooxaha methyl.Cellulose waxay la falgashaa methyl chloride joogitaanka saldhigga, taasoo keentay in lagu beddelo kooxaha hydroxyl kooxaha methyl.
falcelin:
Cellulose-OH+CH3Cl→Cellulose-OMe+Cellulose Hydrochloride-OH+CH3Cl→Cellulose-OMe+HCl
Hydroxypropylation:
Kooxaha Hydroxypropyl waxay ku dheggan yihiin laf dhabarta cellulose iyagoo isticmaalaya propylene oxide.Dareen-celinta waxay inta badan ku dhacdaa dhexdhexaad dhexdhexaad ah oo alkaline ah iyo heerka hydroxypropylation waa la xakameynayaa si loo gaaro sifooyinka la rabo.
falcelin:
Cellulose-OH+C3H6 oxygen→Cellulose-O-(CH2CH(OH)CH3)+H2 oxygen Cellulose-OH+C3H6O
Dhexdhexaadinta iyo nadiifinta:
Badeecada ka soo baxday waa dhexdhexaad si meesha looga saaro hadhaaga aashitada ama aasaasiga ah.Tallaabooyinka nadiifinta sida dhaqidda iyo sifaynta ayaa la sameeyaa si loo helo alaab tayo sare leh oo HPMC ah.
Sifooyinka Kiimikada ee Hydroxypropyl Methylcellulose (HPMC):
Xalka:
HPMC si sahal ah bay ugu milmi kartaa biyo qabow, milmaysana waxa lagu hagaajin karaa iyadoo la bedelayo heerka beddelka.Heerarka beddelka sare ayaa guud ahaan keena kororka milanka.
Sameynta filimka:
HPMC waxay leedahay sifooyin filim samaynta oo heersare ah, taasoo ka dhigaysa mid ku haboon codsiyada sida dahaarka daawada iyo baakadaha cuntada.Filimka soo baxay waa mid hufan wuxuuna bixiyaa xannibaad gaas ah.
Jaleecada kulaylka:
Gelation-ka kulaylka waa hanti gaar ah oo HPMC ah.Gel ayaa sameysma marka la kululeeyo, xoogga jelkuna waxay ku xiran tahay arrimo ay ka mid yihiin xoojinta iyo culeyska unugyada.
Viscosity:
Viscosity ee xalalka HPMC waxaa saameeya heerka beddelka iyo diiradda.Sida dhumuc ahaan, waxaa si weyn loogu isticmaalaa warshadaha kala duwan.
Dhaqdhaqaaqa dusha sare:
HPMC waxa ay leedahay sifooyin u eg kuwa surfactant ah oo gacan ka geysta ku dayashada iyo xasilinta awoodeeda qaabaynta.
La jaanqaadka noole:
HPMC waxa loo tixgaliyaa inay tahay mid noolaha, taasoo ka dhigaysa mid ku haboon in loo isticmaalo dawooyinka, oo ay ku jiraan dawooyinka la xakameeyey ee la sii daayay.
Codsiyada Hydroxypropyl Methylcellulose (HPMC):
daroogada:
HPMC waxa caadi ahaan loo isticmaalaa xidheyaal ahaan, dahaarka filimada, iyo matrijyada siidaynta la kantaroolo ee habaynta dawooyinka.
dhig:
Warshadaha dhismaha, HPMC waxa loo isticmaalaa sidii wakiilka biyaha haynta ee alaabta sibidhka ku salaysan, hagaajinta shaqada iyo yaraynta kala soocida biyaha.
warshadaha cuntada:
HPMC waxa loo isticmaalaa warshadaha cuntada sidii dhumuc, xasiliye iyo wakiilka jeling ahaan.Inta badan waxaa loo isticmaalaa alaabada sida suugada, maraqa iyo jalaatada.
Alaabooyinka daryeelka shakhsi ahaaneed:
Waxyaalaha la isku qurxiyo iyo Warshadaha Daryeelka Shakhsi ahaaneed Isticmaalka HPMC waxaa loo isticmaalaa alaabada sida kiriimyada iyo labeennada sababtoo ah dhumucdooda iyo waxsoosaarkooda.
Rinjiyeynta iyo Dahaarka:
HPMC waxaa lagu daraa rinjiyada iyo dahaarka si loo kordhiyo viscosity, xasiloonida iyo haynta biyaha.
Gabagabadii:
Hydroxypropyl methylcellulose waa polymer isku dhafan oo leh codsiyo kala duwan oo kala duwan sababtoo ah sifooyinka kiimikada gaarka ah.Isku-dubaridka HPMC waxay ku lug leedahay soo bandhigida kooxaha methyl iyo hydroxypropyl ee laf-dhabarka cellulose, taas oo keentay biyo-milmi iyo biocompatible polymer.Codsiyada kala duwan ee daawooyinka, dhismaha, cuntada iyo daryeelka shakhsi ahaaneed waxay muujinayaan muhiimada ay u leedahay warshadaha kala duwan.Sida cilmi-baadhistu sii socoto, wax ka beddelka iyo horumarka tignoolajiyada HPMC waxa laga yaabaa inay balaadhiso adeeggeeda oo kor u qaaddo waxqabadkeeda codsiyada jira iyo kuwa soo baxaya.
Waqtiga boostada: Dec-18-2023