ʻO nā mea kōkua lāʻau lapaʻau Cellulose Etera

ʻO ka cellulose ether kūlohelohe kahi huaʻōlelo maʻamau no ke ʻano onā mea hoʻopuka cellulosehana ʻia e ka hopena o ka cellulose alkali a me ka etherifying agent ma lalo o kekahi mau kūlana.He huahana kahi i hoʻololi ʻia ai nā pūʻulu hydroxyl ma nā macromolecules cellulose e nā hui ether.Hoʻohana nui ʻia nā cellulose ethers i nā ʻoihana o ka ʻaila, nā mea kūkulu hale, nā uhi, nā meaʻai, nā lāʻau lapaʻau, a me nā kemika o kēlā me kēia lā.Ma nā ʻano like ʻole, aia nā huahana lāʻau lapaʻau ma waena a me nā kahua kiʻekiʻe o ka ʻoihana, me ka waiwai hoʻohui kiʻekiʻe.Ma muli o nā koi koʻikoʻi koʻikoʻi, paʻakikī hoʻi ka hana ʻana o ka cellulose ether lāʻau lapaʻau.Hiki ke ʻōlelo ʻia ʻo ka maikaʻi o nā huahana pharmaceutical-grade hiki ke hōʻike i ka ikaika ʻenehana o nā ʻoihana cellulose ether.Hoʻohui pinepine ʻia ka cellulose ether ma ke ʻano he blocker, mea matrix a me ka mānoanoa e hana i nā papa matrix hoʻokuʻu mau, nā mea hoʻoheheʻe gastric-soluble, nā mea hoʻopaʻa microcapsule hoʻokuʻu ʻia, nā mea kiʻi lāʻau hoʻokuʻu mau, etc.

Sodium carboxymethyl cellulose:

ʻO Carboxymethyl cellulose sodium (CMC-Na) ka ʻano cellulose ether me ka hana nui a me ka hoʻohana ʻana ma ka home a ma waho.ʻO ia ka ionic cellulose ether i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka etherification me ka chloroacetic acid.ʻO CMC-Na kahi mea hoʻohana lāʻau lapaʻau maʻamau.Hoʻohana pinepine ʻia ʻo ia ma ke ʻano he mea hoʻopaʻa no ka hoʻomākaukau paʻa, kahi mea mānoanoa, kahi mea mānoanoa, a me kahi mea hoʻomaha no ka hoʻomākaukau wai.Hiki ke hoʻohana ʻia ma ke ʻano he matrix hoʻoheheʻe wai a me nā mea hana kiʻiʻoniʻoni.Hoʻohana pinepine ʻia ʻo ia ma ke ʻano he kiʻiʻoniʻoni lāʻau hoʻokuʻu hoʻomau a me ka papa matrix hoʻokuʻu hoʻokuʻu ʻia i nā hoʻomākaukau hoʻokuʻu hoʻomau.

Ma waho aʻe o ka sodium carboxymethylcellulose ma ke ʻano he lāʻau lapaʻau, hiki ke hoʻohana ʻia ka sodium croscarmellose e like me ka excipient lāʻau lapaʻau.ʻO ka sodium Croscarmellose (CCMC-Na) he huahana hiki ʻole ke hoʻoheheʻe ʻia i ka wai o ka carboxymethylcellulose reacting me ka crosslinking agent ma kahi mahana (40-80°C) ma lalo o ka hana a kahi mea hoʻoheheʻe inorganic acid a hoʻomaʻemaʻe ʻia.Ma ke ʻano he crosslinking agent, propylene glycol, succinic anhydride, maleic anhydride a me adipic anhydride hiki ke hoʻohana ʻia.Hoʻohana ʻia ka sodium Croscarmellose ma ke ʻano he disintegrant no nā papa, capsules a me nā granules i ka hoʻomākaukau waha.Ke hilinaʻi nei ia i nā hopena capillary a me ka pehu e wāwahi.Loaʻa iā ia ka compressibility maikaʻi a me ka ikaika disintegration ikaika.Ua hōʻike nā haʻawina e ʻoi aku ka nui o ka pehu o ka sodium croscarmellose i loko o ka wai ma mua o nā mea hoʻopau maʻamau e like me ka sodium carmellose haʻahaʻa a me ka cellulose microcrystalline hydrated.

Methylcellulose:

ʻO ka Methyl cellulose (MC) kahi ether non-ionic cellulose i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka methyl chloride etherification.Methylcellulose loaʻa ka wai hoʻoheheʻe maikaʻi a paʻa i ka laulā o pH2.0 ~ 13.0.Hoʻohana nui ʻia ia i nā excipients pharmaceutical, a hoʻohana ʻia i nā papa sublingual, intramuscular injections, ophthalmic preparations, waha capsules, oral suspensions, waha papa a me nā hoʻomākaukau topical.Eia kekahi, ma ka hoʻomākaukau hoʻokuʻu hoʻomau, hiki ke hoʻohana ʻia ka MC e like me ka hydrophilic gel matrix i hoʻopaʻa ʻia i ka hoʻokuʻu ʻana, nā mea hoʻoheheʻe gastric-soluble, nā mea hoʻopaʻa microcapsule i hoʻokuʻu ʻia, nā mea kiʻi lāʻau hoʻokuʻu mau, etc.

Hydroxypropyl methyl cellulose:

ʻO ka Hydroxypropyl methylcellulose (HPMC) he cellulose non-ionic i hui ʻia eter i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization, propylene oxide a me methyl chloride etherification.ʻAʻohe ona, ʻono ʻole, ʻona ʻole, hiki ke hoʻoheheʻe ʻia i ka wai anuanu a gelled i ka wai wela.ʻO Hydroxypropyl methylcellulose kahi ʻano cellulose i hui pū ʻia me ka nui o ka ulu ʻana, ka nui a me ka maikaʻi i Kina i nā makahiki he 15 i hala.ʻO ia kekahi o nā mea hoʻohana lāʻau lapaʻau i hoʻohana nui ʻia ma ka home a ma waho.makahiki o ka moolelo.I kēia manawa, ʻike ʻia ka hoʻohana ʻana o HPMC ma nā ʻano ʻelima:

ʻO kekahi ma ke ʻano he mea hoʻopaʻa a hoʻopau.Ma ke ʻano he mea hoʻopaʻa, hiki i ka HPMC ke hoʻomaʻemaʻe i ka lāʻau, a hiki iā ia ke hoʻonui i nā haneli mau manawa ma hope o ka lawe ʻana i ka wai, no laila hiki iā ia ke hoʻomaikaʻi nui i ka helu hemo a i ʻole ka hoʻokuʻu ʻana o ka papa.Loaʻa i ka HPMC ka viscosity ikaika, hiki ke hoʻonui i ka viscosity particle a hoʻomaikaʻi i ka hoʻopili ʻana o nā mea maka me ka ʻano crisp a brittle.Hiki ke hoʻohana ʻia ka HPMC me ka viscosity haʻahaʻa e like me ka binder a me ka disintegrant, a ʻo nā mea me ka viscosity kiʻekiʻe hiki ke hoʻohana wale ʻia e like me ka binder.

ʻO ka lua ma ke ʻano he mea hoʻokuʻu paʻa a mālama ʻia no ka hoʻomākaukau waha.ʻO ka HPMC kahi mea maʻamau hydrogel matrix i hoʻomākaukau ʻia i hoʻokuʻu ʻia.Hiki ke hoʻohana ʻia ka HPMC ma ke ʻano he binder, viscosifier a me suspending agent, a me ka high-viscosity grade (4000-100000mPa·s) hiki ke hoʻohana ʻia ka HPMC no ka hoʻomākaukau ʻana i nā mea i hui ʻia. nā papa hoʻokuʻu lōʻihi.Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai ʻōpū, loaʻa nā pōmaikaʻi o ka compressibility maikaʻi, ka wai maikaʻi, ka hiki ke hoʻouka lāʻau ikaika, a me nā ʻano hoʻokuʻu lāʻau ʻaʻole i hoʻopilikia ʻia e PH.He mea koʻikoʻi nui ka mea lawe hydrophilic i nā ʻōnaehana hoʻomākaukau hoʻokuʻu hoʻomau a hoʻohana pinepine ʻia e like me ka Hydrophilic gel matrix a me nā mea uhi no ka hoʻomākaukau hoʻokuʻu hoʻomau, a me nā mea kōkua no ka hoʻomākaukau ʻana o ka ʻōpū a me nā hoʻomākaukau kiʻi lāʻau hoʻokuʻu mau.

ʻO ke kolu he mea hoʻouhi kiʻiʻoniʻoni.Loaʻa iā HPMC nā waiwai hana kiʻiʻoniʻoni maikaʻi.ʻO ke kiʻiʻoniʻoni i hana ʻia e ia he ʻano like, ʻikea a paʻakikī, a ʻaʻole maʻalahi ke paʻa i ka wā hana.ʻOi loa no nā lāʻau lapaʻau e maʻalahi ke komo i ka makū a paʻa ʻole, me ka hoʻohana ʻana iā ia ma ke ʻano he papa hoʻokaʻawale hiki ke hoʻomaikaʻi nui i ke kūpaʻa o ka lāʻau lapaʻau a pale ʻO ke kiʻiʻoniʻoni e hoʻololi i ke kala.Loaʻa i ka HPMC nā ʻano kikoʻī viscosity.Inā koho pono ʻia, ʻoi aku ka maikaʻi a me ke ʻano o nā papa i uhi ʻia ma mua o nā mea ʻē aʻe.ʻO ka manaʻo maʻamau he 2% a 10%.

ʻO ka hā he mea capsule.I nā makahiki i hala iho nei, me nā maʻi maʻi maʻi holoholona honua, i hoʻohālikelike ʻia me nā capsules gelatin, ua lilo nā capsules meaʻai i mea aloha hou o ka ʻoihana lāʻau a me nā meaʻai.Ua hoʻopuka maikaʻi ʻo Pfizer o ʻAmelika Hui Pū ʻIa i ka HPMC mai nā mea kanu kūlohelohe a hoʻomākaukau i nā capsule mea kanu VcapTM.Hoʻohālikelike ʻia me nā capsules hollow gelatin kuʻuna, loaʻa i nā capsules mea kanu nā mea maikaʻi o ka hiki ke hoʻololi ʻia, ʻaʻohe pilikia o nā hopena cross-linking a me ke kūpaʻa kiʻekiʻe.ʻO ka hoʻokuʻu ʻana o ka lāʻau lapaʻau ʻano paʻa, a liʻiliʻi nā ʻokoʻa o kēlā me kēia kanaka.Ma hope o ka hemo ʻana i loko o ke kino o ke kanaka, ʻaʻole i komo a hiki ke hoʻokuʻu ʻia Hoʻokuʻu ʻia ka mea mai ke kino.Ma ke ʻano o ka mālama ʻana, ma hope o ka nui o nā hoʻāʻo, ʻaneʻane ʻaʻole palupalu ia ma lalo o nā kūlana haʻahaʻa haʻahaʻa, a paʻa mau nā waiwai o ka pūpū capsule ma lalo o nā kūlana haʻahaʻa kiʻekiʻe, a ʻaʻole pili nā hōʻailona o nā capsules mea kanu ma lalo o ka mālama nui. kūlana.Me ka hoʻomaopopo ʻana o ka poʻe i nā capsules mea kanu a me ka hoʻololi ʻana o nā manaʻo lāʻau lapaʻau lehulehu ma ka home a ma waho, e ulu wikiwiki ka mākeke no nā capsules mea kanu.

ʻO ka lima ma ke ʻano he mea hoʻomaha.ʻO ka hoʻomākaukau ʻana i ka wai ʻano hoʻokuʻu ʻia he ʻano lāʻau lapaʻau maʻamau i hoʻohana ʻia, ʻo ia kahi ʻōnaehana dispersion heterogeneous kahi e hoʻopuehu ʻia ai nā lāʻau paʻa ʻole i loko o kahi ʻano hoʻopuehu wai.Hoʻoholo ka paʻa o ka ʻōnaehana i ka maikaʻi o ka hoʻomākaukau ʻana i ka wai hoʻomaha.Hiki i ka HPMC colloidal solution ke ho'ēmi i ka paʻa-wai interfacial tension, e hoʻemi i ka ikehu manuahi o nā ʻāpana paʻa, a hoʻopaʻa i ka ʻōnaehana heterogeneous dispersion.He lāʻau hoʻomaha maikaʻi loa ia.Hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa no nā kulu maka, me kahi maʻiʻo o 0.45% a 1.0%.

Hydroxypropyl Cellulose:

ʻO ka Hydroxypropyl cellulose (HPC) kahi ether non-ionic cellulose i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka propylene oxide etherification.Hiki ke hoʻoheheʻe ʻia ka HPC i ka wai ma lalo o 40 ° C a me ka nui o nā solvents polar, a ua pili kāna hana i ka ʻike o ka hui hydroxypropyl a me ke degere o ka polymerization.Hiki ke hoʻohālikelike ʻia ka HPC me nā lāʻau like ʻole a loaʻa ka inertia maikaʻi.

Hoʻohana nui ʻia ka hydroxypropyl cellulose haʻahaʻa haʻahaʻa (L-HPC) e like me ka disintegrant papa a me ka binder.-HPC hiki ke hoʻonui i ka paʻakikī a me ka'ōlinolino o ka papa, a hiki ke hoʻopau koke i ka papa, hoʻomaikaʻi i ka maikaʻi o loko o ka papa, a hoʻomaikaʻi i ka hopena curative.

Hiki ke hoʻohana ʻia ka hydroxypropyl cellulose (H-HPC) i mea hoʻopili no nā papa, granules, a me nā granules maikaʻi ma ke kahua lāʻau.Loaʻa i ka H-HPC nā waiwai hana kiʻiʻoniʻoni maikaʻi loa, a ʻo ke kiʻi i loaʻa he paʻakikī a elastic, hiki ke hoʻohālikelike ʻia me nā plasticizers.Hiki ke hoʻomaikaʻi hou ʻia ka hana ʻana o ke kiʻiʻoniʻoni ma o ka hui ʻana me nā mea hoʻoheheʻe ʻē aʻe, a ua hoʻohana pinepine ʻia ʻo ia ma ke ʻano he mea uhi kiʻiʻoniʻoni no nā papa.Hiki ke hoʻohana ʻia ʻo H-HPC ma ke ʻano he mea matrix no ka hoʻomākaukau ʻana i nā papa hoʻokuʻu hoʻokuʻu ʻia matrix, nā pellets hoʻokuʻu ʻia a me nā papa hoʻokuʻu hoʻokuʻu pālua.

Hydroxyethyl cellulose

ʻO ka Hydroxyethyl cellulose (HEC) kahi ether non-ionic cellulose i hana ʻia mai ka pulupulu a me ka lāʻau ma o ka alkalization a me ka etherification o ka ethylene oxide.Ma ke kahua o ka lāʻau lapaʻau, hoʻohana nui ʻia ʻo HEC ma ke ʻano he mānoanoa, colloidal protection agent, adhesive, dispersant, stabilizer, suspending agent, film-forming agent a me nā mea hoʻokuʻu paʻa, a hiki ke hoʻopili ʻia i nā emulsions topical, ʻaila, kulu maka, ʻO ka wai waha, ka papa paʻa, ka capsule a me nā ʻano hana ʻē aʻe.Ua hoʻopaʻa ʻia ʻo Hydroxyethyl cellulose i ka US Pharmacopoeia/US National Formulary a me ka European Pharmacopoeia.

Ethyl cellulose:

ʻO Ethyl cellulose (EC) kekahi o nā mea i hoʻohana nui ʻia i ka wai-insoluble cellulose derivatives.ʻAʻole ʻawaʻawa ʻo EC, paʻa, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai, ka waikawa a i ʻole ka hopena alkali, a hiki ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe kūlohelohe e like me ka ethanol a me ka methanol.ʻO ka mea hoʻoheheʻe maʻamau i hoʻohana ʻia ʻo toluene/ethanol ma ke ʻano he 4/1 (kaumaha) i hui pū ʻia.He nui ka hoʻohana ʻana o EC i ka hoʻomākaukau hoʻokuʻu ʻana i ka lāʻau lapaʻau, hoʻohana nui ʻia e like me nā mea lawe, microcapsules, a me ka uhi ʻana i nā mea hana kiʻiʻoniʻoni no ka hoʻomākaukau ʻana i hoʻokuʻu ʻia, e like me nā papa papa, nā mea hoʻopili, a me nā mea hoʻonaninani kiʻiʻoniʻoni, hoʻohana ʻia ma ke ʻano he kiʻiʻoniʻoni matrix e hoʻomākaukau ai. nā ʻano papa like ʻole o ka matrix sustained-release papa, hoʻohana ʻia ma ke ʻano he mea hui e hoʻomākaukau ai i nā mea hoʻomākaukau hoʻokuʻu paʻa i uhi ʻia, nā pellets hoʻokuʻu paʻa, a hoʻohana ʻia ma ke ʻano he mau mea kōkua encapsulation e hoʻomākaukau ai i nā microcapsules hoʻokuʻu mau;hiki ke hoʻohana nui ʻia ma ke ʻano he mea lawe no ka hoʻomākaukau ʻana i nā dispersion paʻa;hoʻohana nui ʻia i ka ʻenehana lāʻau lapaʻau ma ke ʻano he kiʻiʻoniʻoni a me ka uhi pale, a me ka mea hoʻopili a me ka hoʻopiha.Ma keʻano he pale pale o ka papa, hiki iā ia ke hoʻemi i ka naʻau o ka papa i ka haʻahaʻa a pale i ka lāʻau mai ka hoʻopiliʻana i ka wai, ka weheʻana a me ka pōʻino;Hiki iā ia ke hana i kahi papa gel hoʻokuʻu lohi, microencapsulate i ka polymer, a hiki i ka hoʻokuʻu mau ʻana o ka hopena lāʻau.