IHydroxypropylmethylcellulose (HPMC) iyi-polymer yokwenziwa esetshenziswa kabanzi etholakala emikhiqizweni eyahlukene okuhlanganisa izimonyo, imithi, upende nokudla.Yenziwa ngokushintsha i-cellulose ngokusabela kwamakhemikhali e-propylene oxide ne-methyl chloride.I-HPMC inezinto ezimbalwa ezifiselekayo, ezifana nokungewona ubuthi, okungacunuli, okubolayo, nokuhambisanayo.Enye yezinto zayo eziyingqayizivele yikhono layo lokuthinta ukudluliswa kokukhanya.Kulesi sihloko, sihlola izici ezihlukahlukene eziholela ku-HPMCs ezithinta ezokuthutha ezilula kanye nokusetshenziswa okungenzeka kwalesi sakhiwo.
Enye yezinto eziyinhloko ezithinta izakhiwo zokudlulisa ukukhanya kwe-HPMC ukwakheka kwayo kwamangqamuzana.I-HPMC iyi-polymer enamagatsha ehlanganiswe ne-cellulose namayunithi aphindayo e-methyl hydroxypropyl.Isisindo samangqamuzana e-HPMC sincike kuzinga layo lokushintsha (DS), isilinganiso senani le-hydroxypropyl namaqembu e-methyl ngeyunithi ngayinye ye-cellulose.I-HPMC ene-DS ephezulu inamaqembu e-hydroxypropyl kanye ne-methyl, okuholela esisindweni samangqamuzana esiphezulu kanye nomthelela obaluleke kakhulu ekudluliseni ukukhanya.
Esinye isici esibalulekile esithinta ukudluliswa kokukhanya ukugcwala kwe-HPMC esixazululweni.Lapho i-HPMC incibilika emanzini, kwakhiwa isisombululo esicacile nesisobala ezindaweni eziphansi.Njengoba ukugxila kukhula, isisombululo siba ne-viscous kakhudlwana futhi ukudlulisa kuncipha ngenxa yokusabalalisa ukukhanya.Ubukhulu balo mphumela buncike esisindweni samangqamuzana, i-DS kanye nezinga lokushisa lesixazululo.
Isici sesithathu esithinta ukudluliswa kokukhanya yi-pH yesisombululo.I-HPMC i-amphoteric polymer engakwazi ukusebenza njenge-asidi ebuthakathaka kanye nesisekelo esibuthakathaka, kuye nge-pH yesisombululo.Nge-pH ephansi, i-hydroxypropyl kanye namaqembu e-methyl ku-HPMC aba yi-protonated, okuholela ekuncipheni kokuncibilika kanye nokuncipha kokudluliswa kokukhanya.Nge-pH ephezulu, umgogodla we-cellulose we-HPMC uyasuswa, okuholela ekwandeni kokuncibilika nokudluliswa kokukhanya.
Isici sesine esithinta ukudluliswa kokukhanya ukuba khona kwezinye izinhlanganisela ezifana nosawoti, ama-surfactants kanye nezincibilikisi ezihlangene.Lezi zinhlanganisela zingasebenzisana ne-HPMC, zibangele izinguquko esakhiweni sayo samangqamuzana nokuncibilika, ngaleyo ndlela kuthinte ukudluliswa kokukhanya.Isibonelo, ukufaka usawoti kungakhuphula amandla e-ionic esixazululo, okuholela ekuncipheni kokuncibilika kanye nokwanda kokuhlakazeka kokukhanya.Ngakolunye uhlangothi, ukuba khona kwama-surfactants kungashintsha ukungezwani kwendawo yesisombululo, okuholela ekunciphiseni kwe-viscosity kanye nokwanda kokudluliswa kokukhanya.
Izakhiwo zokudlulisa ukukhanya ze-HPMC zinezinhlelo zokusebenza ezihlukahlukene.Embonini yezemithi, i-HPMC isetshenziswa njenge-thickener, binder kanye ne-disintegrant kumaphilisi namaphilisi.Ikhono layo lokuthinta ukudluliswa kokukhanya likwenza kube usizo njengento yokumboza engavikela izithako ezisebenzayo ekonakalisweni okubangelwa ukukhanya.Izakhiwo ezihlakaza ukukhanya ze-HPMC futhi ziyenza ibe ikhandidethi elifanele lezinhlelo zokulethwa kwezidakamizwa ezilawulwayo ezidinga ukukhululwa okuqhubekayo kwezithako ezisebenzayo.
Ngaphezu kwemithi, izakhiwo zokudlulisa ukukhanya ze-HPMC nazo zisetshenziswa embonini yokudla.I-HPMC isetshenziswa esikhundleni samafutha ekudleni okunamafutha aphansi kanye nekhalori ephansi.Ikhono layo lokwenza amajeli e-viscous futhi azinzile ezixazululweni ezinamanzi alenza libe isithako esikahle semikhiqizo efana nezingubo zesaladi, imayonnaise namasoso.Izakhiwo ezihlakaza ukukhanya ze-HPMC nazo zingasetshenziswa ukudala ukubukeka okuguqubele eziphuzweni ezifana nejusi yezithelo neziphuzo zezemidlalo.
Kafushane, i-hydroxypropylmethylcellulose (HPMC) iyi-polymer yokwenziwa ebalulekile ngenxa yezakhiwo zayo ezihlukile, okuhlanganisa amandla okuthinta ukudluliswa kokukhanya.Izinto ezithinta ukudluliswa kokukhanya kwe-HPMC zifaka ukwakheka kwayo kwamangqamuzana, ukugxilisa ingqondo, i-pH, kanye nokuba khona kwezinye izinhlanganisela.Izakhiwo zokudlulisa ukukhanya ze-HPMC zinezicelo ezimbalwa ezingase zibe khona embonini yemithi nokudla, okuhlanganisa ukulethwa kwezidakamizwa okulawulwayo nokudla okunamafutha amancane.Njengoba ucwaningo lwezakhiwo ze-HPMC luqhubeka, izicelo eziningi zingatholwa.
Isikhathi sokuthumela: Aug-02-2023