IHydroxypropylmethylcellulose (HPMC) yipolima yokwenziwa esetyenziswa ngokubanzi efumaneka kwiimveliso ezahlukeneyo ezibandakanya izinto zokuthambisa, amayeza, iipeyinti kunye nokutya.Yenziwe ngokuguqula i-cellulose ngokusabela kweekhemikhali zepropylene oxide kunye ne-methyl chloride.I-HPMC ineempawu ezininzi ezinqwenelekayo, ezinje nge-non-toxic, non-riteting, biodegradable, kunye ne-biocompatible.Enye yeempawu zayo ezizodwa kukukwazi ukuchaphazela ukuhanjiswa kokukhanya.Kweli nqaku, siphonononga izinto ezahlukeneyo ezikhokelela kwii-HPMC ezichaphazela ukuthuthwa kokukhanya kunye nokusetyenziswa okunokwenzeka kwale propati.
Enye yezinto eziphambili ezichaphazela iimpawu zokuhambisa ukukhanya kwe-HPMC yisakhiwo sayo se-molecular.I-HPMC yi-polymer ene-branched eyenziwe nge-cellulose kunye neeyunithi eziphindayo ze-methyl hydroxypropyl.Ubunzima bemolekyuli ye-HPMC buxhomekeke kwisidanga sayo sokuthatha indawo (DS), umyinge wenani le-hydroxypropyl kunye namaqela e-methyl ngeyunithi nganye yeseli.I-HPMC ene-DS ephezulu ine-hydroxypropyl kunye namaqela e-methyl, okukhokelela kubunzima obuphezulu bemolekyuli kunye neempembelelo ezibaluleke ngakumbi ekugqithiseni ukukhanya.
Enye into ebalulekileyo echaphazela ukuhanjiswa kokukhanya kukuxinana kwe-HPMC kwisisombululo.Xa i-HPMC ichithwe emanzini, isisombululo esicacileyo nesicacileyo senziwe kwiindawo eziphantsi.Njengoko ugxininiso lukhula, isisombululo siba yi-viscous ngakumbi kwaye i-transmittance iyancipha ngenxa yokusabalalisa ukukhanya.Ubungakanani besi siphumo buxhomekeke kubunzima bemolekyuli, i-DS kunye nobushushu besisombululo.
Into yesithathu echaphazela ukuhanjiswa kokukhanya yi-pH yesisombululo.I-HPMC i-polymer amphoteric enokuthi isebenze njenge-asidi ebuthathaka kunye nesiseko esibuthathaka, kuxhomekeke kwi-pH yesisombululo.Kwi-pH ephantsi, i-hydroxypropyl kunye namaqela e-methyl kwi-HPMC iba yiprotonated, ekhokelela ekunciphiseni ukunyibilika kunye nokunciphisa ukuhanjiswa kokukhanya.Kwi-pH ephezulu, i-cellulose backbone ye-HPMC i-deprotonated, ekhokelela ekunyukeni kwe-solubility kunye nokuhanjiswa kokukhanya.
Into yesine echaphazela ukuhanjiswa kokukhanya kubukho bezinye iikhompawundi ezifana neetyuwa, i-surfactants kunye ne-co-solvents.Ezi zixhobo zinokusebenzisana ne-HPMC, zibangela utshintsho kwisakhiwo sayo se-molecular kunye nokunyibilika, ngaloo ndlela kuchaphazela ukuhanjiswa kokukhanya.Ngokomzekelo, ukongeza ityuwa kunokunyusa amandla e-ionic esisombululo, okukhokelela ekunciphiseni ukunyibilika kunye nokwanda kokusabalalisa ukukhanya.Ngakolunye uhlangothi, ubukho be-surfactants bunokutshintsha ukunyanzeliswa komphezulu wesisombululo, okukhokelela ekunciphiseni kwe-viscosity kunye nokwanda kokuhanjiswa kokukhanya.
Iimpawu zokuhambisa ukukhanya kwe-HPMC zineendlela ezahlukeneyo zokusebenzisa.Kushishino lwamayeza, i-HPMC isetyenziswa njenge-thickener, binder kunye ne-disintegrant kwiipilisi kunye nee-capsules.Ikhono layo lokuchaphazela ukuhanjiswa kokukhanya kwenza kube luncedo njengento yokugqoka enokukhusela izithako ezisebenzayo ekuthotyweni okubangelwa ukukhanya.Iipropathi zokusasaza ukukhanya kwe-HPMC zikwenza ukuba ibe ngumgqatswa ofanelekileyo kwiinkqubo zokuhanjiswa kweziyobisi ezilawulwayo ezifuna ukukhutshwa okuzinzileyo kwezithako ezisebenzayo.
Ukongeza kumayeza, iipropathi zokuhambisa ukukhanya ze-HPMC zikwasetyenziswa kwishishini lokutya.I-HPMC isetyenziswa njenge-fat substitute kwi-fat-low-fat and low-calorie foods.Ukukwazi ukwenza i-viscous kunye ne-gel ezinzile kwizisombululo zamanzi kwenza ukuba ibe yinto efanelekileyo kwiimveliso ezifana nokugqoka isaladi, i-mayonnaise kunye ne-sauces.Iimpawu zokusasaza ukukhanya kwe-HPMC zisenokusetyenziswa ukwenza inkangeleko enamafu kwiziselo ezifana nejusi yeziqhamo kunye neziselo zemidlalo.
Isishwankathelo, i-hydroxypropylmethylcellulose (HPMC) iyipolymer exabisekileyo yokwenziwa ngenxa yeempawu zayo ezizodwa, kubandakanywa ukukwazi ukuchaphazela ukuhanjiswa kokukhanya.Izinto ezichaphazela ukuhanjiswa kokukhanya kwe-HPMC zibandakanya ubume bayo bemolekyuli, ukugxila, i-pH, kunye nobukho bezinye iikhompawundi.Iimpawu zokuhambisa ukukhanya kwe-HPMC zinezicelo ezininzi ezinokubakho kumashishini amayeza kunye nokutya, kubandakanywa ukuhanjiswa kweziyobisi okulawulwayo kunye nokutya okunamafutha aphantsi.Njengoko uphando kwiipropati ze-HPMCs luqhubeka, izicelo ezininzi zinokufunyanwa.
Ixesha lokuposa: Aug-02-2023