Hydroxypropylmethylcellulose (HPMC) bụ polymer sịntetik a na-ejikarị eme ihe nke a na-ahụ n'ọtụtụ ngwaahịa gụnyere ihe ịchọ mma, ọgwụ, agba na nri.A na-eme ya site n'ịgbanwe cellulose site na mmeghachi omume kemịkal nke propylene oxide na methyl chloride.HPMC nwere ọtụtụ ihe a na-achọsi ike, dị ka ndị na-adịghị egbu egbu, na-adịghị ewe iwe, biodegradable, na biocompatible.Otu n'ime ihe ndị pụrụ iche ya bụ ikike ya imetụta nnyefe ọkụ.N'isiokwu a, anyị na-enyocha ihe dị iche iche na-eduga na HPMC na-emetụta ụgbọ njem ọkụ yana ngwa nwere ike ime nke a.
Otu n'ime ihe ndị bụ isi na-emetụta njirimara nnyefe ọkụ nke HPMC bụ usoro ihe omimi ya.HPMC bụ polymer nwere alaka nke mejupụtara cellulose na methyl hydroxypropyl na-emegharị nkeji.The molekụla arọ nke HPMC dabere n'ókè nke nnọchi ya (DS), nkezi ọnụ ọgụgụ nke hydroxypropyl na methyl otu kwa cellulose unit.HPMC nwere DS dị elu nwere ọtụtụ hydroxypropyl na methyl, na-ebute ibu arọ molekụla dị elu yana mmetụta dị ịrịba ama na nnyefe ọkụ.
Ihe ọzọ dị mkpa na-emetụta nnyefe ọkụ bụ ntinye nke HPMC na ngwọta.Mgbe HPMC na-agbaze na mmiri, a na-emepụta ngwọta doro anya na nke doro anya na obere mkpokọta.Ka ntinye uche na-abawanye, ihe ngwọta na-aghọwanye viscous na nnyefe na-ebelata n'ihi ịgbasa ọkụ.Ogo nke mmetụta a na-adabere na ịdị arọ molekụla, DS na okpomọkụ nke ngwọta.
Ihe nke atọ na-emetụta nnyefe ọkụ bụ pH nke ngwọta.HPMC bụ polymer amphoteric nke nwere ike ime dị ka acid na-adịghị ike na isi adịghị ike, dabere na pH nke ngwọta.Na pH dị ala, otu hydroxypropyl na methyl na HPMC na-aghọ protonated, na-ebute mbelata solubility na mbelata nnyefe ọkụ.N'ebe pH dị elu, ọkpụkpụ cellulose nke HPMC na-ekpochapụ, na-ebute mmụba solubility na nnyefe ọkụ.
Ihe nke anọ na-emetụta nnyefe ọkụ bụ ọnụnọ nke ogige ndị ọzọ dị ka nnu, surfactants na co-solvents.Ogige ndị a nwere ike imekọrịta ihe na HPMC, na-eme ka mgbanwe dị na nhazi ya na solubility ya, si otú ahụ na-emetụta nnyefe ọkụ.Dịka ọmụmaatụ, ịgbakwụnye nnu nwere ike ịbawanye ike ionic nke ngwọta, na-ebute mbelata solubility na mmụba ọkụ ọkụ.N'aka nke ọzọ, ọnụnọ nke surfactants nwere ike ịgbanwe nhụsianya elu nke ngwọta, na-eme ka mbelata viscosity na mmụba nke nnyefe ọkụ.
Njirimara na-ebunye ọkụ nke HPMC nwere ngwa dị iche iche.N'ime ụlọ ọrụ na-emepụta ọgwụ, a na-eji HPMC eme ihe dị ka ihe na-agbakọ, ihe nkedo na nke na-agbasa na mbadamba na capsules.Ikike ya imetụta nnyefe ọkụ na-eme ka ọ baa uru dị ka ihe mkpuchi nke nwere ike ichebe ihe ndị na-arụ ọrụ site na mmebi nke ọkụ.Njirimara na-achụsasị ọkụ nke HPMC na-emekwa ka ọ bụrụ onye kwesịrị ekwesị maka usoro nnyefe ọgwụ a na-achịkwa nke chọrọ ntọhapụ nke ihe ndị na-arụ ọrụ.
Na mgbakwunye na ọgwụ, a na-ejikwa ihe ndị na-ebunye ọkụ nke HPMC na ụlọ ọrụ nri.A na-eji HPMC dị ka ihe nnọchi abụba na nri ndị nwere obere abụba na obere kalori.Ikike ya ịmepụta gels viscous na kwụsiri ike na mmiri mmiri na-eme ka ọ bụrụ ihe dị mma maka ngwaahịa dị ka uwe salad, Mayonezi na sauces.A pụkwara iji ihe na-agbasasị ọkụ nke HPMC mee ka ọdịdị ígwé ojii dị na ihe ọṅụṅụ dị ka ihe ọṅụṅụ mkpụrụ osisi na ihe ọṅụṅụ egwuregwu.
Na nchịkọta, hydroxypropylmethylcellulose (HPMC) bụ polymer synthetic bara uru n'ihi ihe pụrụ iche ya, gụnyere ike imetụta nnyefe ọkụ.Ihe ndị na-emetụta nnyefe ọkụ nke HPMC gụnyere usoro ihe omimi ya, ntinye uche, pH, na ọnụnọ nke ogige ndị ọzọ.Njirimara na-ebunye ọkụ nke HPMC nwere ọtụtụ ngwa nwere ike na ụlọ ọrụ ọgwụ na nri, gụnyere nnyefe ọgwụ na-achịkwa na nri ndị nwere obere abụba.Ka nyocha gbasara akụrụngwa nke HPMC na-aga n'ihu, enwere ike ịchọta ngwa ndị ọzọ.
Oge nzipu: Ọgọst-02-2023