ʻO ka Hydroxypropylmethylcellulose (HPMC) he polymer synthetic i hoʻohana nui ʻia i loaʻa i nā ʻano huahana like ʻole me nā mea hoʻonaninani, nā lāʻau lapaʻau, nā pena a me nā meaʻai.Hana ʻia ia ma ka hoʻololi ʻana i ka cellulose ma o ka hopena kemika o propylene oxide a me methyl chloride.Loaʻa i ka HPMC kekahi mau waiwai i makemake ʻia, e like me ka mea ʻawaʻawa, ʻaʻole hoʻonāukiuki, biodegradable, a biocompatible.ʻO kekahi o kāna mau waiwai kūʻokoʻa, ʻo ia ka hiki ke hoʻopili i ka lawe māmā.Ma kēia ʻatikala, ʻimi mākou i nā kumu like ʻole e alakaʻi ai i nā HPMC e pili ana i ka lawe māmā a me nā noi kūpono o kēia waiwai.
ʻO kekahi o nā kumu nui e pili ana i nā waiwai lawe māmā o HPMC ʻo kona ʻano molekala.ʻO ka HPMC he polimer lālā i haku ʻia me ka cellulose a me ka methyl hydroxypropyl repeating units.ʻO ke kaumaha molekala o HPMC e pili ana i kona degere o ka hoʻololi ʻana (DS), ka helu awelika o nā pūʻulu hydroxypropyl a me nā methyl no ka pūʻulu cellulose.ʻO ka HPMC me ka DS kiʻekiʻe aʻe ka nui o nā hui hydroxypropyl a me methyl, ka hopena i ke kaumaha molecular kiʻekiʻe a me ka hopena koʻikoʻi i ka transmittance māmā.
ʻO kekahi kumu koʻikoʻi e pili ana i ka transmittance māmā ʻo ia ka neʻe ʻana o ka HPMC i ka hopena.Ke hoʻoheheʻe ʻia ka HPMC i ka wai, ua hoʻokumu ʻia kahi hopena maʻemaʻe a akaka ma nā haʻahaʻa haʻahaʻa.Ke piʻi aʻe ka hoʻonui ʻana, lilo ka hopena i ʻoi aku ka viscous a emi ka transmittance ma muli o ka lūlū māmā.ʻO ka nui o kēia hopena e pili ana i ke kaumaha molekala, DS a me ka mahana o ka hopena.
ʻO ke kolu o ka mea e pili ana i ka transmittance māmā ʻo ia ka pH o ka hopena.ʻO ka HPMC he polymer amphoteric hiki ke hana ma ke ʻano he ʻakika nāwaliwali a me kahi kumu nāwaliwali, ma muli o ka pH o ka hopena.Ma ka pH haʻahaʻa, lilo nā pūʻulu hydroxypropyl a me methyl ma HPMC i protonated, ka hopena i ka hoʻohaʻahaʻa i ka solubility a me ka hoʻemi ʻana i ka transmittance māmā.Ma ka pH kiʻekiʻe, ua hoʻopau ʻia ka iwi kuamoʻo cellulose o HPMC, e hoʻonui ai i ka solubility a me ka transmittance māmā.
ʻO ke kumu ʻehā e pili ana i ka lawe māmā ʻana, ʻo ia ka loaʻa ʻana o nā pūhui ʻē aʻe e like me nā paʻakai, surfactants a me nā co-solvents.Hiki i kēia mau pūhui ke launa pū me HPMC, e hoʻololi i kona ʻano molekala a me ka solubility, a laila e hoʻopili ai i ka lawe māmā.No ka laʻana, hiki i ka hoʻohui ʻana i ka paʻakai ke hoʻonui i ka ikaika ionic o kahi hopena, ka hopena o ka hoʻohaʻahaʻa ʻana a me ka hoʻonui ʻana i ka lūlū māmā.Ma ka ʻaoʻao ʻē aʻe, hiki i ka hiki ʻana o nā surfactants ke hoʻololi i ka ʻili o ka ʻili o ka hopena, ka hopena i ka emi ʻana o ka viscosity a me ka hoʻonui ʻana i ka transmittance māmā.
Loaʻa nā ʻano hana like ʻole o nā ʻano hoʻoili māmā o HPMC.I ka ʻoihana lāʻau lapaʻau, hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa, hoʻopaʻa a me ka disintegrant i nā papa a me nā capsules.ʻO kona hiki ke hoʻopili i ka hoʻoili māmā ʻana he mea pono ia ma ke ʻano he mea uhi e hiki ke pale i nā mea hana mai ka hoʻohaʻahaʻa ʻana i ka māmā.ʻO nā waiwai hoʻopuehu māmā o HPMC e lilo ia i moho kūpono no nā ʻōnaehana lawe lāʻau i mālama ʻia e koi ana i ka hoʻokuʻu mau ʻana o nā mea hana.
Ma waho aʻe o nā lāʻau lapaʻau, hoʻohana pū ʻia nā mea uila uila o HPMC i ka ʻoihana meaʻai.Hoʻohana ʻia ka HPMC ma ke ʻano he momona momona i nā meaʻai haʻahaʻa momona a haʻahaʻa-calorie.ʻO kona hiki ke hana i nā gels viscous a paʻa i loko o nā wai wai e lilo ia i mea hoʻohui kūpono no nā huahana e like me nā pāpale salakeke, ka mayonnaise a me nā kīʻaha.Hiki ke hoʻohana ʻia nā waiwai hoʻopuʻi māmā o HPMC e hana i kahi ʻano opua i nā mea inu e like me nā wai huaʻai a me nā mea inu haʻuki.
I ka hōʻuluʻulu ʻana, ʻo ka hydroxypropylmethylcellulose (HPMC) kahi polymer synthetic waiwai ma muli o kāna mau waiwai kūʻokoʻa, me ka hiki ke hoʻopili i ka lawe māmā.ʻO nā mea e pili ana i ka hoʻouna māmā ʻana o HPMC e pili ana i kona ʻano molekala, ka ʻike ʻana, ka pH, a me ka loaʻa ʻana o nā pūhui ʻē aʻe.ʻO nā waiwai hoʻouna māmā o HPMC he mau mea hiki ke hoʻohana ʻia i ka lāʻau lapaʻau a me nā ʻoihana meaʻai, me ka lawe ʻana i ka lāʻau lapaʻau a me nā meaʻai haʻahaʻa momona.Ke hoʻomau nei ka noiʻi ʻana i nā waiwai o nā HPMC, hiki ke ʻike ʻia nā noi hou aʻe.
Ka manawa hoʻouna: ʻAukake-02-2023