IHydroxypropylmethylcellulose (HPMC) i-cellulose ether esetshenziswa kabanzi ezimbonini ezimbalwa ezifana nemithi, izimonyo, ukudla, nezokwakha.Ngenxa yokuguquguquka kwayo kanye nezakhiwo ezizuzisayo, i-HPMC isibe isithako esidumile ekwenziweni okuhlukahlukene.Njengamanje, kunezinhlobo ezimbalwa zama-HPMC emakethe, ngayinye enezakhiwo ezihlukile nezinhlelo zokusebenza.
I-HPMC iyi-polymer ye-cellulose eguqulwe ngamakhemikhali etholwe ngokuphendula i-cellulose nge-methyl chloride ne-propylene oxide.Lokhu kusabela kwethula amaqembu e-methyl kanye ne-hydroxypropyl esakhiweni se-cellulose, enze i-polymer encibilikayo emanzini, engeyona i-ionic kanye nokusebenza okuphezulu.Kodwa-ke, izinhlobo ezihlukene ze-HPMC zinamadigri ahlukene okushintsha (DS) amaqembu e-methyl kanye ne-hydroxypropyl, anquma izici zawo zomzimba namakhemikhali.
Ngokuvamile, imikhiqizo ye-HPMC ihlukaniswa ngokuya nge-viscosity kanye nenani le-DS.I-Viscosity iyisici esibalulekile se-HPMC njengoba ithinta ukunyibilika komkhiqizo, ikhono lokwenza ifilimu kanye nekhono lokujiya.Ngakolunye uhlangothi, inani le-DS linquma izinga lokushintshwa kwe-polymer kanjalo nezinga le-hydrophobicity yohlobo lwe-HPMC.Ngakho-ke, izinhlobo ezihlukene ze-HPMC zitholwa ngokuhlukahluka kwe-viscosity yazo kanye namanani e-DS.Ngezansi kunezinhlobo ezivame kakhulu ze-HPMC nokuthi zihluke kanjani.
1. Ibanga elijwayelekile HPMC
I-HPMC yebanga elivamile ine-methyl DS esukela ku-0.8 kuye ku-2.0 kanye ne-hydroxypropyl DS esukela ku-0.05 ukuya ku-0.3.Lolu hlobo lwe-HPMC lutholakala ebangeni elibanzi lamabanga e-viscosity ukusuka ku-3cps ukuya ku-200,000cps.I-HPMC yebanga elivamile inokuncibilika okuhle emanzini futhi yakha izixazululo ezicacile, okuyenza ifanelekele izinhlelo zokusebenza ezihlukahlukene ezimbonini zokudla, ezemithi nezimonyo.Ama-HPMC anjalo avame ukusetshenziswa njengamafilimu, ama-thickeners, ama-emulsifiers kanye neziqinisi ekudleni nasezimonyoni.
2. Ukufakwa esikhundleni okuphansi kwe-HPMC
I-HPMC efakwe endaweni ephansi inedigri ephansi ye-methyl ne-hydroxypropyl esikhundleni kune-HPMC yebanga elivamile.Lolu hlobo oluthile lwe-HPMC lune-methyl DS esukela ku-0.2 kuya ku-1.5 kanye ne-hydroxypropyl DS esukela ku-0.01 kuya ku-0.2.Imikhiqizo ye-HPMC eshintshwayo ephansi ine-viscosity ephansi, ngokuvamile ephakathi kuka-3-400cps, futhi imelana kakhulu nosawoti nama-enzyme.Lezi zakhiwo zenza i-HPMC efakwe endaweni ephansi ifanele imikhiqizo yokudla efana nobisi, ibhikawozi nemikhiqizo yenyama.Ukwengeza, i-HPMC efakwe endaweni ephansi iphinde isetshenziswe njenge-binder, i-disintegrant kanye ne-ejenti yokuhlanganisa ithebhulethi embonini yezemithi.
3. High esikhundleni HPMC
Izinga eliphezulu lokushintsha i-HPMC inezinga eliphezulu lokushintshwa kwe-methyl ne-hydroxypropyl kune-HPMC yebanga elijwayelekile.Lolu hlobo lwe-HPMC lune-methyl DS esukela ku-1.5 kuya ku-2.5 kanye ne-hydroxypropyl DS esukela ku-0.1 kuya ku-0.5.Imikhiqizo efakwe endaweni ephezulu ye-HPMC ine-viscosity ephezulu, esukela ku-100,000cps kuya ku-200,000cps, futhi inezindawo eziqinile zokugcina amanzi.Lezi zakhiwo zenza i-HPMC ethathelwe indawo ephezulu ibe ilungele ukusetshenziswa emkhakheni wezokwakha, njengemikhiqizo esekwe usimende, okokunamathela kanye nezinamatheliso.I-HPMC efakwe endaweni ephezulu iphinde isetshenziswe njenge-binder, thickener kanye ne-ejenti yokukhulula embonini yezemithi.
4. I-Methoxy-Ethoxy HPMC
I-Methoxy-Ethoxy HPMC iwuhlobo oluklanywe ngokukhethekile lwe-HPMC enezinga eliphezulu lokushintshwa kwe-ethoxy.Amaqembu e-ethoxy andisa i-hydrophobicity ye-HPMC, ayenze ingancibiliki kalula emanzini kune-HPMC yebanga elivamile.Nge-methyl DS esukela ku-1.5 kuya ku-2.5 kanye ne-ethoxy DS esukela ku-0.4 kuya ku-1.2, i-methoxy-ethoxy HPMC ilungele ukusetshenziswa emikhiqizweni esekelwe kuwoyela njengezimonyo, amapende nama-coatings.Lolu hlobo lwe-HPMC lwakha ifilimu ezinzile futhi efanayo enikeza isiphetho esibushelelezi, esicwebezelayo emkhiqizweni wokugcina.
5. I-HPMC eyimbudumbudu
I-HPMC eyi-Granular wuhlobo lwe-HPMC enosayizi wezinhlayiyana ezincane, ngokuvamile phakathi kwama-microns angu-100-200.I-HPMC eyi-Granular isetshenziswa embonini yezemithi njenge-binder yethebhulethi, i-disintegrant kanye ne-ejenti yokukhululwa eqhubekayo.Usayizi wezinhlayiyana ezincane zezinhlayiya ze-HPMC uvumela ukusatshalaliswa okulinganayo kwezithako, okuholela kumkhiqizo ongaguquki nothembekile.I-HPMC eyi-Granular ine-methyl DS esukela ku-0.7 kuye ku-1.6 kanye ne-hydroxypropyl DS esukela ku-0.1 kuye ku-0.3.
IHydroxypropylmethylcellulose (HPMC) iyi-polymer esebenza ngezinto eziningi enezinhlobonhlobo zezinhlelo zokusebenza ezimbonini ezahlukahlukene.Izinhlobo ze-HPMC zihlukaniswa ngokuya nge-viscosity kanye nevelu ye-DS, enquma izakhiwo zazo zomzimba namakhemikhali.I-HPMC yebanga elivamile, i-HPMC yokushintshanisa ephansi, i-HPMC efaka esikhundleni esiphezulu, i-methoxyethoxy HPMC kanye ne-HPMC eyimbudumbudu yizinhlobo ezivame kakhulu ze-HPMC.Ukuqonda umehluko phakathi kwalezi zinhlobo kuzovumela abaklami ukuthi basebenzise amandla aphelele e-HPMC ukuze bakhiqize ikhwalithi ephezulu nemikhiqizo yokugcina enamandla.
Isikhathi sokuthumela: Sep-06-2023