Hydroxypropylmethylcellulose (HPMC) ke cellulose ether e sebelisoang haholo liindastering tse 'maloa tse kang meriana, litlolo, lijo le kaho.Ka lebaka la ho feto-fetoha ha maemo le thepa e molemo, HPMC e fetohile motsoako o tsebahalang mekhoeng e fapaneng.Hajoale, ho na le mefuta e mengata ea li-HPMC 'marakeng, e' ngoe le e 'ngoe e na le thepa le lits'ebetso tse ikhethang.
HPMC ke khemikhale e fetotsoeng cellulose polymer e fumanoang ka ho arabela selulose ka methyl chloride le propylene oxide.Karabelo ena e kenyelletsa lihlopha tsa methyl le hydroxypropyl ka har'a sebopeho sa cellulose, ho etsa polima e qhibilihang ka metsing, e seng ea ionic le e sebetsang hantle haholo.Leha ho le joalo, mefuta e fapaneng ea HPMC e na le likhato tse fapaneng tsa substitution (DS) ea lihlopha tsa methyl le hydroxypropyl, tse khethollang litšobotsi tsa tsona tsa 'mele le tsa lik'hemik'hale.
Ka kakaretso, lihlahisoa tsa HPMC li arotsoe ho latela viscosity le boleng ba DS.Viscosity ke thepa ea bohlokoa ea HPMC kaha e ama ho qhibiliha ha sehlahisoa, bokhoni ba ho etsa filimi le bokhoni ba ho tenya.Ka lehlakoreng le leng, boleng ba DS bo lekanya tekanyo ea ho fetola polima, kahoo tekanyo ea hydrophobicity ea mofuta oa HPMC.Ka hona, mefuta e fapaneng ea HPMC e fumanoa ka ho fapana ha viscosity ea bona le boleng ba DS.Ka tlase ke mefuta e atileng haholo ea HPMC le hore na e fapana joang.
1. Tloaelehileng grade HPMC
HPMC ea maemo a tloaelehileng e na le methyl DS ho tloha ho 0.8 ho isa ho 2.0 le hydroxypropyl DS ho tloha ho 0.05 ho isa ho 0.3.Mofuta ona oa HPMC o fumaneha ka mefuta e mengata ea limaraka tsa viscosity ho tloha ho 3cps ho isa ho 200,000cps.HPMC ea maemo a tloaelehileng e na le ho qhibiliha ha metsi hantle 'me e etsa litharollo tse hlakileng, e etsa hore e tšoanelehe bakeng sa lits'ebetso tse fapaneng indastering ea lijo, ea meriana le ea litlolo.Li-HPMC tse joalo li sebelisoa hangata joalo ka baetsi ba lifilimi, li-thickeners, li-emulsifiers le li-stabilizers lijong le litlolong.
2. Phatlalatso e tlase HPMC
HPMC e nkeloang sebaka e tlase e na le tekanyo e tlase ea methyl le hydroxypropyl substitute ho feta kereiti e tloaelehileng ea HPMC.Mofuta ona o khethehileng oa HPMC o na le methyl DS ho tloha ho 0.2 ho ea ho 1.5 le hydroxypropyl DS ho tloha ho 0.01 ho ea ho 0.2.Lihlahisoa tse tlase tsa HPMC li na le viscosity e tlase, hangata lipakeng tsa 3-400cps, 'me li hanyetsana haholo le letsoai le li-enzyme.Mehaho ena e etsa hore HPMC e be boemong bo tlase e loketse lihlahisoa tsa lijo tse kang lebese, likuku le lihlahisoa tsa nama.Ntle le moo, HPMC e kentsoeng sebakeng se tlase e boetse e sebelisoa e le setlamo, sehlaseli le sekoaelo sa matlapa indastering ea meriana.
3. Phahamiso e phahameng ea HPMC
HPMC e phahameng e na le sebaka se phahameng sa methyl le hydroxypropyl ho feta kereiti e tloaelehileng ea HPMC.Mofuta ona oa HPMC o na le methyl DS ho tloha ho 1.5 ho isa ho 2.5 le hydroxypropyl DS ho tloha ho 0.1 ho ea ho 0.5.Lihlahisoa tsa HPMC tse nkeloang sebaka haholo li na le viscosity e phahameng, ho tloha ho 100,000cps ho isa ho 200,000cps, 'me li na le thepa e matla ea ho boloka metsi.Thepa ena e etsa hore HPMC e nkeloe sebaka ke sebaka se loketseng ho sebelisoa lekaleng la kaho, joalo ka lihlahisoa tse thehiloeng ho samente, lirafshoa le likhomaretsi.HPMC e nkeloang sebaka haholo e boetse e sebelisoa e le se tlamellang, se teteaneng le se lokollang indastering ea meriana.
4. Methoxy-Ethoxy HPMC
Methoxy-Ethoxy HPMC ke mofuta o khethehileng oa HPMC o nang le boemo bo phahameng ba ho fetola ethoxy.Lihlopha tsa ethoxy li eketsa hydrophobicity ea HPMC, e etsa hore e se ke ea qhibiliha ka metsing ho feta sehlopha se tloaelehileng sa HPMC.Ka methyl DS ho tloha ho 1.5 ho isa ho 2.5 le ethoxy DS ho tloha ho 0.4 ho ea ho 1.2, methoxy-ethoxy HPMC e loketse ho sebelisoa lihlahisoa tse entsoeng ka oli tse kang litlolo, lipente le litlolo.Mofuta ona oa HPMC o etsa filimi e tsitsitseng le e ts'oanang e fanang ka qetello e boreleli, e benyang ho sehlahisoa sa ho qetela.
5. Granular HPMC
Granular HPMC ke mofuta oa HPMC e nang le boholo bo bonyenyane, hangata bo pakeng tsa 100-200 microns.Granular HPMC e sebelisoa indastering ea meriana e le setlamo sa letlapa, se senyang le sa tokollo e tsitsitseng.Karolo e nyane ea likaroloana tsa HPMC e lumella kabo e lekanang ea metsoako, e hlahisang sehlahisoa se ts'oanang le se tšepahalang.Granular HPMC e na le methyl DS ho tloha ho 0.7 ho isa ho 1.6 le hydroxypropyl DS ho tloha ho 0.1 ho ea ho 0.3.
Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e nang le mefuta e mengata ea lisebelisoa liindastering tse fapaneng.Mefuta ea HPMC e arotsoe ho latela viscosity le boleng ba DS, tse khethollang thepa ea bona ea 'mele le ea lik'hemik'hale.HPMC ea kamehla, substitution e tlase HPMC, high substitution HPMC, methoxyethoxy HPMC le granular HPMC ke mefuta e atileng haholo ea HPMC.Ho utloisisa phapang lipakeng tsa mefuta ena ho tla lumella baetsi ba lihlahisoa ho sebelisa monyetla o felletseng oa li-HPMC ho hlahisa lihlahisoa tsa boleng bo holimo le tse matla.
Nako ea poso: Sep-06-2023