I-Hydroxypropyl methylcellulose (i-Hypromellose), eyaziwa ngokuba yi-hypromellose, i-white to white cellulose powder okanye i-granule, eneempawu zokunyibilika kumanzi abandayo kwaye ayinyibiliki emanzini ashushu afana ne-methyl cellulose.Iqela le-hydroxypropyl kunye neqela le-methyl lidibaniswe ne-glucose ye-anhydrous ring ye-cellulose nge-ether bond, eluhlobo lwe-non-ionic cellulose exutywe i-ether.Yi-semisynthetic, engasebenzi, i-viscoelastic polymer edla ngokusetyenziswa njenge-lubricant kwi-ophthalmology, okanye njenge-excipient okanye isithuthi kumayeza omlomo.
ukulungiselela
I-pulp yephepha le-kraft paper pulp efunyenwe kwi-pine wood kunye nomxholo we-alpha cellulose we-97%, i-viscosity yangaphakathi ye-720 ml / g, kunye ne-avareji yefiber ubude be-2.6 mm yantywiliselwa kwi-49% yesisombululo samanzi se-NaOH kwi-40 ° C. imizuzwana engama-50;ipulp efunyenweyo emva koko yacudiswa ukuze kususwe i-49% engaphezulu ye-NaOH enamanzi ukufumana i-alkali cellulose.Umlinganiselo wobunzima (i-49% ye-NaOH isisombululo se-aqueous) ukuya (umxholo oqinileyo kwi-pulp) kwisinyathelo sokukhulelwa kwaba ngu-200. Umlinganiselo wobunzima (umxholo we-NaOH kwi-cellulose ye-alkali efunyenwe ngaloo ndlela) kunye (umxholo oqinileyo kwi-pulp) 1.49.I-alkali cellulose efunyenwe ngaloo ndlela (i-20 kg) yafakwa kwi-reactor yoxinzelelo lwejacket kunye nokuvuselela kwangaphakathi, emva koko ikhutshwe kwaye ihlanjululwe nge-nitrogen ukususa ngokwaneleyo i-oksijini kwi-reactor.Emva koko, ukuvuselela kwangaphakathi kwenziwa ngelixa kulawulwa ubushushu kwi-reactor ukuya kuma-60 ° C.Emva koko, i-2.4 kg ye-dimethyl ether yongezwa, kwaye iqondo lokushisa kwi-reactor lilawulwa ukuba ligcinwe kwi-60 ° C.Emva kokufaka i-dimethyl ether, yongeza i-dichloromethane ukwenzela ukuba i-molar ratio ye (dichloromethane) ukuya (icandelo le-NaOH kwi-alkaline cellulose) yi-1.3, kwaye ungeze i-propylene oxide ukwenza (i-propylene oxide) kunye (kwi-pulp) Umlinganiselo wobunzima bomxholo oqinileyo) yatshintshwa yaba yi-1.97, ngelixa iqondo lokushisa kwi-reactor lilawulwa ukusuka kwi-60 ° C ukuya kwi-80 ° C.Emva kokongezwa kwe-methyl chloride kunye nepropylene oxide, iqondo lokushisa kwi-reactor lilawulwa ukusuka kwi-80 ° C ukuya kuma-90 ° C.Ngaphezu koko, ukusabela kwaqhubeka kwi-90 ° C imizuzu engama-20.Emva koko, irhasi yakhutshwa kwi-reactor, kwaye ke i-hydroxypropyl methylcellulose ekrwada yakhutshwa kwireactor.Ubushushu be-hydroxypropyl methylcellulose ekrwada ngexesha lokukhutshwa yayingama-62 degreesC.I-50% yobungakanani bamasuntswana obungakanani obusekwe kubunzima obongezelekayo obumiselwe ngokusekwe kumlinganiselo we-hydroxypropyl methylcellulose ekrwada edlula kwiindawo zokuvuleka kwezisefu ezintlanu, isisefu ngasinye esinobukhulu obahlukeneyo bokuvula, silinganisiwe.Ngenxa yoko, umyinge we-particle ye-particle ye-coarse particles yayingu-6.2 mm.I-hydroxypropyl methylcellulose ekrwada efunyenwe ngaloo ndlela yaziswa kwi-biaxial kneader eqhubekayo (KRC kneader S1, L/D=10.2, umthamo wangaphakathi we-0.12 ilitha, isantya sokujikeleza 150 rpm) ngesantya se-10 kg / hr, kwaye ukubola kwafunyanwa.yehydroxypropyl methylcellulose ekrwada.Umyinge wesayizi ye-particle yayiyi-1.4 mm njengoko ilinganiswe ngokufanayo kusetyenziswa iisefu ze-5 ezahlukeneyo zobukhulu bokuvula.Kwi-hydroxypropyl methylcellulose ekrwada ebolileyo kwitanki enolawulo lobushushu bebhatyi, yongeza amanzi ashushu kwi-80 ° C kwisixa esinokuthi ( Ubungakanani bobunzima besixa seselulosi) ukuya (ixabiso lilonke lodaka) latshintshwa laya ku-0.1, kwaye kwafunyanwa uludaka.I-slurry yashukunyiswa kwiqondo lokushisa elingaguqukiyo lama-80 ° C imizuzu engama-60.Emva koko, i-slurry yondliwa kwi-preheated rotary filter filter (imveliso ye-BHS-Sonthofen) kunye nesantya sokujikeleza kwe-0.5 rpm.Ubushushu boludaka lwalungama-93°C.I-slurry yanikezelwa kusetyenziswa ipompo, kwaye uxinzelelo lokukhutshwa kompompo lwaluyi-0.2 MPa.Ubungakanani bokuvula isihluzo sokucoca uxinzelelo lwe-rotary lwaluyi-80 μm, kwaye indawo yokucoca yayiyi-0.12 m 2.I-slurry enikezelwe kwisihluzi soxinzelelo lwe-rotary iguqulelwa kwikhekhe lokucoca ngokuhluzwa kokucoca.Emva kokubonelela ngomphunga we-0.3 MPa kwikhekhe efunyenwe ngaloo ndlela, amanzi ashushu kwi-95 ° C anikezelwa ngokomlinganiselo wokuba umlinganiselo wobunzima (amanzi ashushu) ukuya (umxholo oqinileyo we-hydroxypropyl methylcellulose emva kokuhlamba) wawuyi-10.0, Emva koko, hluza ngokusebenzisa isihluzo.Amanzi ashushu anikezelwa yimpompo kuxinzelelo lokukhupha lwe-0.2 MPa.Emva kokuba kunikezelwe ngamanzi ashushu, i-steam ye-0.3 MPa yanikezelwa.Emva koko, imveliso ehlanjwe kwindawo yokucoca isuswe yi-scraper kwaye ikhutshwe kumatshini wokuhlamba.Amanyathelo ukusuka ekondleni i-slurry ukukhupha imveliso ehlanjiweyo iqhutyelwa ngokuqhubekayo.Njengomphumo wokulinganisa usebenzisa i-hygrometer yodidi lokumisa ubushushu, umxholo wamanzi wemveliso ehlanjiweyo ngaloo ndlela ukhutshiwe yi-52.8%.Imveliso ehlanjiweyo ekhutshiweyo kwisihluzo soxinzelelo olujikelezayo yomiswa kusetyenziswa isomisi somoya kwi-80° C., yaza yacolwa kwisixhobo sokusila sokusila sokusila ukuze kufumaneke i-hydroxypropyl methylcellulose.
isicelo
Le mveliso isetyenziswa njenge-thickener, dispersant, binder, emulsifier kunye ne-stabilizer kushishino lwamalaphu.Ikwasetyenziswa ngokubanzi kwi-synthetic resin, i-petrochemicals, i-ceramics, iphepha, isikhumba, amayeza, ukutya, izinto zokuthambisa kunye namanye amashishini.
Ixesha lokuposa: Nov-15-2022