Application of HPMC in preparation

1 as film coating material and film-forming material

Using hypromellose (HPMC) as the film-coated tablet material, compared with traditional coated tablets such as sugar-coated tablets, the coated tablets have no obvious advantages in masking the taste of medicine and appearance, but their hardness and friability , moisture absorption, disintegration, coating weight gain and other quality indicators are better. The low-viscosity grade of this product is used as a water-soluble film coating material for tablets and pills, and the high-viscosity grade is used as a film-coating material for organic solvent systems. The concentration is usually 2.0% to 20%.

2 as binder and disintegrant

The low-viscosity grade of this product can be used as a binder and disintegrant for tablets, pills, and granules, and the high-viscosity grade can only be used as a binder. The dosage varies with different models and requirements. Generally, the dosage of binder for dry granulation tablets is 5%, and the dosage of binder for wet granulation tablets is 2%.

3 as suspending agent

The suspending agent is a viscous gel substance with hydrophilicity, which can slow down the sedimentation speed of the particles when used in the suspending agent, and it can be attached to the surface of the particles to prevent the particles from aggregating and shrinking into a ball. Suspending agents play a vital role in making suspensions. HPMC is an excellent variety of suspending agents, and its dissolved colloidal solution can reduce the tension of the liquid-solid interface and the free energy on small solid particles, thereby enhancing the stability of the heterogeneous dispersion system. The high-viscosity grade of this product is used as a suspension-type liquid preparation prepared as a suspending agent. It has a good suspending effect, is easy to redisperse, does not stick to the wall, and has fine flocculated particles. The usual dosage is 0.5% to 1.5%.

4 as a blocker, sustained release agent and pore-causing agent

The high-viscosity grade of this product is used to prepare hydrophilic gel matrix sustained-release tablets, blockers and controlled-release agents for mixed material matrix sustained-release tablets, and has the effect of delaying drug release. Its use concentration is 10%~80% (W /W). Low-viscosity grades are used as pore-forming agents for sustained-release or controlled-release preparations. The initial dose required for the therapeutic effect of this type of tablet can be achieved quickly, and then exert a sustained-release or controlled-release effect, and the effective blood drug concentration is maintained in the body . When hypromellose meets water, it hydrates to form a gel layer. The mechanism of drug release from the matrix tablet mainly includes the diffusion of the gel layer and the erosion of the gel layer.

5 as a thickener and colloidal protective glue

When this product is used as a thickener, the commonly used concentration is 0.45%~1.0%. This product can also increase the stability of hydrophobic glue, form a protective colloid, prevent particles from agglomerating and agglomerating, thereby inhibiting the formation of sediment, and its usual concentration is 0.5%~1.5%.

6 as capsule material

Usually the capsule shell capsule material of capsule is based on gelatin. The production process of the gelatin capsule shell is simple, but there are some problems and phenomena such as poor protection against moisture and oxygen sensitive drugs, low drug dissolution rate, and delayed disintegration of the capsule shell during storage. Therefore, hypromellose, as a substitute for gelatin capsules, is used in the preparation of capsules, which improves the formability and use effect of capsules, and has been widely promoted at home and abroad.

7 as a bioadhesive

Bioadhesion technology, the use of excipients with bioadhesive polymers, through adhesion to the biological mucosa, enhances the continuity and tightness of the contact between the preparation and the mucosa, so that the drug is slowly released and absorbed by the mucosa to achieve therapeutic purposes. It is currently widely used It is used to treat diseases of the nasal cavity, oral mucosa and other parts. Gastrointestinal bioadhesion technology is a new drug delivery system developed in recent years. It not only prolongs the residence time of pharmaceutical preparations in the gastrointestinal tract, but also improves the contact performance between the drug and the cell membrane at the absorption site, changing the fluidity of the cell membrane, Enhance the penetration of the drug to the intestinal epithelial cells, thereby improving the bioavailability of the drug.

8 as a topical gel

As an adhesive preparation for skin, gel has a series of advantages such as safety, beauty, easy cleaning, low cost, simple preparation process, and good compatibility with drugs. direction.

9 as a sedimentation inhibitor in an emulsification system