Kushandiswa kweHPMC mukugadzirira

1 semafirimu ekuputira zvinhu uye firimu-kugadzira zvinhu

Uchishandisa hypromellose (HPMC) senge firimu-yakavharwa piritsi rekushandisa, kana ichienzaniswa neyakajairwa mahwendefa akadai seshuga-yakavharwa mapiritsi, iwo mahwendefa akaputirwa haana mabhenefiti ari pachena mukuvharisa kuravira kwemushonga uye chitarisiko, asi kuoma kwavo uye friability , kunyura munyoro, kuparara, kuvhara uremu kuwedzera uye zvimwe zviratidzo zvemhando zviri nani.Iyo yakaderera-viscosity giredhi yechigadzirwa ichi inoshandiswa semvura-inonyungudika firimu yekuputira zvinhu zvemapiritsi nemapiritsi, uye iyo yepamusoro-viscosity giredhi inoshandiswa senge firimu-kupfeka zvinhu zve organic solvent masisitimu.Iko kusungirirwa kunowanzo 2.0% kusvika 20%.

2 sebhainda uye disintegrant

Iyo yakaderera-viscosity giredhi yechigadzirwa ichi inogona kushandiswa sebhainda uye disintegrant yemapiritsi, mapiritsi, uye granules, uye yakakwirira-viscosity giredhi inogona kungoshandiswa sebhainda.Chiyero chinosiyana nemhando dzakasiyana uye zvinodiwa.Kazhinji, dosage yebinder yemapiritsi egranulation yakaoma i5%, uye dosage yebinder yemapiritsi ekunyorova i2%.

3 semumiriri wekumisa

Iyo inomisa mumiriri iine viscous gel chinhu chine hydrophilicity, iyo inogona kudzikamisa sedimentation kumhanya kwezvimedu kana ichinge yashandiswa mune inomisa mumiriri, uye inogona kusungirirwa pamusoro pezvimedu kudzivirira zvimedu kuti zvisabatana uye kuderera kuita bhora. .Kumisa mabasa kunoita basa rakakosha pakuita kuti vanhu vamiswe.HPMC yakanakisa akasiyana ekumisa maajenti, uye yakanyungudika colloidal mhinduro inogona kuderedza kushushikana kweiyo liquid-solid interface uye yemahara simba pane madiki masisitimu, nekudaro ichiwedzera kugadzikana kweiyo heterogeneous dispersion system.Iyo yakakwira-viscosity giredhi yechigadzirwa ichi inoshandiswa seyekumiswa-mhando yegadziriro yemvura yakagadzirirwa semumiriri wekumisa.Iyo ine yakanaka kumisa mhedzisiro, iri nyore kuparadzirazve, haina kunamatira kumadziro, uye ine yakanaka flocculated particles.Iyo yakajairika dosage ndeye 0.5% kusvika 1.5%.

4 se blocker, inosimudzira kuburitsa mumiririri uye pore-inokonzera mumiriri

Iyo yepamusoro-viscosity giredhi yechigadzirwa ichi inoshandiswa kugadzirira hydrophilic gel matrix inosimudzira-kuburitswa mahwendefa, blockers uye inodzorwa-kuburitsa maajenti eakasanganiswa zvinhu matrix akasimudzira-kuburitswa mahwendefa, uye ane mhedzisiro yekunonoka kuburitswa kwezvinodhaka.Iko kushandiswa kwayo kwe10% ~ 80% (W / W).Low-viscosity mamakisi anoshandiswa semapore-forming agents ekusimudzira-kuburitswa kana kudzorwa-kuburitsa gadziriro.Mushonga wekutanga unodiwa pakurapa kwerudzi urwu rwepiritsi unogona kuwanikwa nekukurumidza, uye wobva waita kusimudzira-kuburitswa kana kudzorwa-kuburitsa mhedzisiro, uye inoshanda yeropa zvinodhaka zvinochengetwa mumuviri.Kana hypromellose ikasangana nemvura, inoisa mvura kuti igadzire gel layer.Iyo nzira yekusunungurwa kwezvinodhaka kubva pahwendefa rematrix inonyanya kusanganisira kupararira kwejel layer uye kuputika kwejeri.

5 semukobvu uye colloidal inodzivirira glue

Kana chigadzirwa ichi chikashandiswa seyakakora, iyo inowanzo shandiswa inosvika 0.45% ~ 1.0%.Ichi chigadzirwa chinogona zvakare kuwedzera kugadzikana kwe hydrophobic glue, kuumba inodzivirira colloid, kudzivirira zvimedu kubva kuagglomerating uye agglomerating, nekudaro zvichitadzisa kuumbwa kwe sediment, uye yakajairika kusungwa i 0.5% ~ 1.5%.

6 se capsule zvinhu

Kazhinji iyo capsule shell capsule material ye capsule inobva pane gelatin.Nzira yekugadzirwa kwegelatin capsule shell iri nyore, asi kune mamwe matambudziko uye zviitiko zvakadai sekudzivirira kusina kunaka kubva kune unyoro uye zvinodhaka zvinonzwa oksijeni, kuderera kwezvinodhaka zvinodhaka, uye kunonoka kuparara kwegomba re capsule panguva yekuchengetedza.Nokudaro, hypromellose, sechinzvimbo chegelatin capsules, inoshandiswa mukugadzirira kwe capsules, iyo inovandudza kuumbwa uye kushandiswa kwemaitiro e capsules, uye yakakurudzirwa zvakanyanya kumba nekune dzimwe nyika.

7 se bioadhesive

Bioadhesion tekinoroji, kushandiswa kwezvinobatsira zvine bioadhesive polymers, kuburikidza nekunamatira kune biological mucosa, inosimudzira kuenderera uye kusimba kwekubatana pakati pekugadzirira uye mucosa, kuitira kuti mushonga wacho usunungurwe zvishoma nezvishoma uye unobatwa nemucosa kuti uwane zvinangwa zvekurapa.Iko ikozvino inoshandiswa zvakanyanya Inoshandiswa kurapa zvirwere zvemhino yemhino, mucosa yemuromo uye zvimwe zvikamu.Gastrointestinal bioadhesion tekinoroji inzira nyowani yekuunza zvinodhaka yakagadziriswa mumakore achangopfuura.Haisi kungorebesa nguva yekugara yemishonga yekugadzirira mudumbu, asi zvakare inovandudza kusangana kwekuita pakati pemushonga uye sero membrane panzvimbo yekunyura, kushandura kuyerera kwesero membrane, Kuwedzera kupinda kwemushonga kusvika mudumbu. epithelial masero, nokudaro achivandudza bioavailability yemushonga.

8 senge topical gel

Segadziriro yekunamatira yeganda, gel ine nhevedzano yezvakanakira senge chengetedzo, runako, nyore kuchenesa, mutengo wakaderera, nyore kugadzirira maitiro, uye kuenderana kwakanaka nemishonga.direction.

9 sedimentation inhibitor mune emulsification system