Ukusetshenziswa kwe-HPMC ekulungiseleleni

1 njengezinto zokumboza ifilimu nezinto zokwakha ifilimu

Ukusebenzisa i-hypromellose (HPMC) njengento yethebhulethi ehlanganiswe nefilimu, uma kuqhathaniswa namaphilisi endabuko amboziwe njengamaphilisi ahlanganiswe noshukela, amaphilisi amboziwe awanazo izinzuzo ezisobala ekufihleni ukunambitheka komuthi nokubukeka, kodwa ubulukhuni nokuqina kwawo, ukumuncwa komswakama, ukuhlakazeka, ukunamathela kwesisindo somzimba kanye nezinye izinkomba zekhwalithi zingcono.Ibanga eliphansi le-viscosity lalo mkhiqizo lisetshenziswa njengento yokumboza ifilimu encibilikayo emanzini amaphilisi namaphilisi, futhi izinga le-viscosity ephezulu lisetshenziswa njengento yokumboza ifilimu yezinhlelo ze-organic solvent.I-concentration ngokuvamile i-2.0% kuya ku-20%.

2 njenge-binder ne-disintegrant

Ibanga le-viscosity eliphansi lalo mkhiqizo lingasetshenziswa njenge-binder kanye ne-disintegrant yamaphilisi, amaphilisi, nama-granules, futhi ibanga le-viscosity ephezulu lingasetshenziswa kuphela njenge-binder.Umthamo uyahlukahluka ngamamodeli ahlukene kanye nezidingo.Ngokuvamile, umthamo we-binder wamaphilisi e-granulation owomile ngu-5%, kanti umthamo we-binder kumaphilisi we-granulation omanzi ngu-2%.

3 njenge-ejenti emisiwe

I-ejenti elengayo into yejeli ye-viscous ene-hydrophilicity, enganciphisa isivinini sokudilika kwezinhlayiya uma isetshenziswa ejentini elengayo, futhi ingaxhunywa ebusweni bezinhlayiya ukuvimbela izinhlayiya ukuthi zingahlangani futhi zishwabane zibe yibhola. .Ama-ejenti amisiwe adlala indima ebalulekile ekwenzeni ukumiswa.I-HPMC iwuhlobo oluhle kakhulu lwama-ejenti alengayo, futhi isixazululo sayo se-colloidal esincibilikisiwe singanciphisa ukushuba kwesixhumi esibonakalayo esiqinile-uketshezi namandla amahhala ezinhlayiyeni ezincane eziqinile, ngaleyo ndlela sithuthukise ukuzinza kwesistimu yokuhlakazeka kwe-heterogeneous.Ibanga le-viscosity ephezulu yalo mkhiqizo lisetshenziswa njengendlela yokulungiswa kwamanzi okumisiwe okulungiselelwe njenge-ejenti yokumisa.Inomphumela omuhle wokumisa okwesikhashana, kulula ukuyihlakaza kabusha, ayinamatheli odongeni, futhi inezinhlayiya ezinhle ezintantayo.Umthamo ojwayelekile ngu-0.5% kuya ku-1.5%.

4 njenge-blocker, i-ejenti yokukhululwa okuqhubekayo kanye ne-ejenti ebangela izimbotshana

Ibanga le-viscosity ephezulu yalo mkhiqizo lisetshenziselwa ukulungisa amaphilisi e-hydrophilic gel matrix akhishwa ngokuqhubekayo, ama-blockers nama-ejenti akhishwayo okulawulwayo amaphilisi ezinto ezixubile ze-matrix akhululwa isikhathi eside, futhi anomphumela wokubambezela ukukhululwa kwezidakamizwa.Ukusetshenziswa kwayo ukugxila ku-10% ~ 80% (W / W).Amabanga ane-viscosity ephansi asetshenziswa njengama-ejenti enza izimbotshana zokulungiselela ukukhishwa okuqhubekayo noma ukukhishwa okulawulwayo.Umthamo wokuqala odingekayo ukuze uthole umphumela wokwelapha walolu hlobo lwethebhulethi ungafinyelelwa ngokushesha, bese usebenzisa umphumela wokukhululwa okuzinzile noma olawulwayo, futhi ukugcwala kwezidakamizwa egazini kugcinwa emzimbeni .Lapho i-hypromellose ihlangana namanzi, ithela amanzi ukuze yakhe ungqimba lwejeli.Indlela yokukhishwa kwezidakamizwa kuthebhulethi ye-matrix ikakhulukazi ihlanganisa ukusakazeka kongqimba lwejeli kanye nokuguguleka kongqimba lwejeli.

5 njenge-thickener kanye neglue evikelayo ye-colloidal

Uma lo mkhiqizo usetshenziswa njenge-thickener, ukugxila okuvame ukusetshenziswa ngu-0.45% ~ 1.0%.Lo mkhiqizo ungase futhi ukhuphule ukuzinza kweglue ye-hydrophobic, yakha i-colloid evikelayo, ivimbele izinhlayiya ezivela ku-agglomerating kanye ne-agglomerating, ngaleyo ndlela ivimbele ukwakheka kwe-sediment, futhi ukuhlushwa kwayo okujwayelekile ngu-0.5% ~ 1.5%.

6 njengempahla ye-capsule

Ngokuvamile i-capsule shell capsule impahla ye-capsule isekelwe ku-gelatin.Inqubo yokukhiqiza igobolondo le-gelatin capsule ilula, kodwa kunezinkinga ezithile kanye nezimo ezifana nokuvikeleka okungalungile emithini ezwela umswakama kanye nomoya-mpilo, izinga eliphansi lokuchithwa kwezidakamizwa, kanye nokulibaziseka kokuhlakazeka kwegobolondo le-capsule ngesikhathi sokugcinwa.Ngakho-ke, i-hypromellose, esikhundleni sama-capsules we-gelatin, isetshenziswa ekulungiseleleni ama-capsules, okuthuthukisa ukwakheka nokusetshenziswa kwama-capsules, futhi iye yakhuthazwa kabanzi ekhaya nakwamanye amazwe.

7 njenge-bioadhesive

Ubuchwepheshe be-Bioadhesion, ukusetshenziswa kwezinto ezisizayo ezinama-polymers we-bioadhesive, ngokunamathela ku-mucosa yezinto eziphilayo, kuthuthukisa ukuqhubeka nokuqina kokuxhumana phakathi kokulungiselela kanye ne-mucosa, ukuze umuthi ukhishwe kancane kancane futhi uthathwe yi-mucosa ukufeza izinhloso zokwelapha.Njengamanje isetshenziswa kabanzi Isetshenziselwa ukwelapha izifo ze-nasal cavity, i-mucosa yomlomo nezinye izingxenye.Ubuchwepheshe be-gastrointestinal bioadhesion wuhlelo olusha lokulethwa kwezidakamizwa olwakhiwe eminyakeni yamuva nje.Akugcini nje ukwandisa isikhathi sokuhlala kwamalungiselelo emithi epheshaneni lesisu, kodwa futhi kuthuthukisa ukusebenza kokuxhumana phakathi komuthi kanye nolwelwesi lwamaseli endaweni yokumuncwa, ukuguqula uketshezi lwengqamuzana, Kuthuthukise ukungena komuthi emathunjini. amaseli e-epithelial, ngaleyo ndlela athuthukise i-bioavailability yomuthi.

8 njengejeli ye-topical

Njengokulungiswa okunamathelayo kwesikhumba, ijeli inochungechunge lwezinzuzo ezinjengokuphepha, ubuhle, ukuhlanza okulula, izindleko eziphansi, inqubo elula yokulungiselela, nokuhambisana okuhle nezidakamizwa.isiqondiso.

9 njenge-sedimentation inhibitor ohlelweni lwe-emulsification