Kev thov HPMC hauv kev npaj

1 raws li zaj duab xis txheej khoom thiab zaj duab xis-forming khoom

Siv hypromellose (HPMC) raws li cov khoom siv hauv cov ntsiav tshuaj zaj duab xis, piv nrog cov ntsiav tshuaj coated xws li cov ntsiav tshuaj uas muaj suab thaj, cov ntsiav tshuaj coated tsis muaj qhov zoo tshaj plaws hauv kev npog qhov saj ntawm cov tshuaj thiab cov tsos, tab sis lawv hardness thiab friability, noo noo nqus, disintegration, txheej yuag nce thiab lwm yam zoo qhia tau zoo dua.Cov qib qis viscosity ntawm cov khoom no yog siv los ua cov dej-soluble zaj duab xis txheej cov khoom siv rau cov ntsiav tshuaj thiab cov tshuaj, thiab qib high-viscosity yog siv los ua cov khoom siv zaj duab xis-txheej txheej rau cov kuab tshuaj organic.Cov concentration feem ntau yog 2.0% mus rau 20%.

2 raws li binder thiab disintegrant

Cov qib qis viscosity ntawm cov khoom no tuaj yeem siv los ua ib qho kev sib khi thiab disintegrant rau cov ntsiav tshuaj, tshuaj, thiab granules, thiab qib high-viscosity tsuas yog siv los ua cov ntawv khi.Qhov ntau npaum li cas sib txawv nrog cov qauv sib txawv thiab cov kev xav tau.Feem ntau, qhov ntau npaum li cas ntawm binder rau qhuav granulation ntsiav tshuaj yog 5%, thiab ntau npaum li cas ntawm binder rau ntub granulation ntsiav tshuaj yog 2%.

3 as suspending agent

Tus neeg sawv cev ncua kev kawm ntawv yog ib qho viscous gel tshuaj nrog hydrophilicity, uas tuaj yeem ua rau qeeb qeeb ntawm cov sedimentation ntawm cov khoom thaum siv rau hauv tus neeg sawv cev tshem tawm, thiab nws tuaj yeem txuas rau saum npoo ntawm cov khoom los tiv thaiv cov khoom los ntawm kev sib sau ua ke thiab shrinking rau hauv lub pob. .Suspending agents ua lub luag haujlwm tseem ceeb hauv kev tshem tawm.HPMC yog ib qho zoo heev ntawm kev tshem tawm cov neeg ua haujlwm, thiab nws cov tshuaj yaj yeeb yaj kiab tuaj yeem txo qhov nro ntawm cov kua-khoom sib cuam tshuam thiab lub zog dawb ntawm cov khoom me me, yog li txhim kho kev ruaj ntseg ntawm cov txheej txheem sib txawv.Cov qib high-viscosity ntawm cov khoom no yog siv los ua ib qho kev ncua-hom kua npaj ua tus neeg sawv cev ncua.Nws muaj qhov cuam tshuam zoo, nws yooj yim rau redisperse, tsis lo rau ntawm phab ntsa, thiab muaj nplua flocculated hais.Cov koob tshuaj ib txwm yog 0.5% mus rau 1.5%.

4 raws li ib tug blocker, sustained tso tus neeg sawv cev thiab pore-ua tus neeg saib xyuas

Cov qib high-viscosity ntawm cov khoom no yog siv los npaj hydrophilic gel matrix sustained-tso ntsiav tshuaj, blockers thiab tswj-tso cov neeg ua haujlwm rau cov khoom sib xyaw matrix sustained-tso ntsiav tshuaj, thiab muaj cov nyhuv ntawm ncua sij hawm tso tshuaj.Nws siv concentration yog 10% ~ 80% (W / W).Cov qib qis-viscosity yog siv los ua cov pore-forming cov neeg ua haujlwm rau kev tso tawm los yog tswj-tso npaj.Cov koob tshuaj thawj zaug uas xav tau rau kev kho cov nyhuv ntawm hom ntsiav tshuaj no tuaj yeem ua tiav sai, thiab tom qab ntawd ua kom muaj zog-tso tawm lossis tswj-tso tawm, thiab cov tshuaj ntshav muaj txiaj ntsig zoo yog khaws cia hauv lub cev.Thaum hypromellose ntsib dej, nws hydrates los tsim ib txheej gel.Cov txheej txheem ntawm cov tshuaj tso tawm los ntawm cov ntsiav tshuaj matrix feem ntau suav nrog kev nthuav dav ntawm gel txheej thiab yaig ntawm txheej gel.

5 raws li lub thickener thiab colloidal tiv thaiv kua nplaum

Thaum cov khoom no siv los ua cov thickener, feem ntau siv concentration yog 0.45% ~ 1.0%.Cov khoom no tuaj yeem ua rau muaj kev ruaj ntseg ntawm cov kua nplaum hydrophobic, tsim ib qho kev tiv thaiv colloid, tiv thaiv cov khoom los ntawm agglomerating thiab agglomerating, yog li inhibiting qhov tsim ntawm sediment, thiab nws li ib txwm concentration yog 0.5% ~ 1.5%.

6 raws li cov khoom siv tshuaj ntsiav

Feem ntau cov tshuaj capsule plhaub cov khoom siv ntawm cov tshuaj ntsiav yog raws li gelatin.Cov txheej txheem tsim khoom ntawm gelatin capsule plhaub yog yooj yim, tab sis muaj qee qhov teeb meem thiab tshwm sim xws li kev tiv thaiv tsis zoo ntawm cov dej noo thiab cov pa oxygen rhiab heev, cov tshuaj yaj yeeb tsawg tsawg, thiab ncua sij hawm tawg ntawm lub plhaub capsule thaum khaws cia.Yog li ntawd, hypromellose, raws li ib tug hloov rau gelatin tsiav tshuaj, yog siv nyob rau hauv kev npaj ntawm tsiav tshuaj, uas txhim kho cov formability thiab siv cov nyhuv ntawm capsules, thiab tau lug txhawb nyob rau hauv tsev thiab txawv teb chaws.

7 raws li bioadhesive

Bioadhesion thev naus laus zis, kev siv cov khoom siv nrog bioadhesive polymers, los ntawm adhesion mus rau cov mucosa lom, txhim khu kev txuas ntxiv thiab nruj ntawm kev sib cuag ntawm kev npaj thiab mucosa, kom cov tshuaj maj mam tso tawm thiab nqus los ntawm mucosa kom ua tiav cov hom phiaj kho.Nws yog tam sim no dav siv Nws yog siv los kho cov kab mob ntawm qhov ntswg kab noj hniav, qhov ncauj mucosa thiab lwm qhov chaw.Gastrointestinal bioadhesion thev naus laus zis yog kev xa tshuaj tshiab tsim nyob rau xyoo tas los no.Nws tsis tsuas yog ncua lub sijhawm nyob ntawm cov tshuaj npaj hauv plab hnyuv, tab sis kuj txhim kho kev sib cuag ntawm cov tshuaj thiab cov cell membrane ntawm qhov chaw nqus, hloov cov fluidity ntawm cov cell membrane, txhim kho qhov nkag ntawm cov tshuaj mus rau txoj hnyuv. epithelial hlwb, yog li txhim kho bioavailability ntawm cov tshuaj.

8 raws li cov tshuaj pleev ib ce

Raws li kev npaj nplaum rau ntawm daim tawv nqaij, gel muaj ntau yam zoo xws li kev nyab xeeb, kev zoo nkauj, kev tu yooj yim, tus nqi qis, kev npaj yooj yim, thiab kev sib raug zoo nrog cov tshuaj.kev taw qhia.

9 raws li ib tug sedimentation inhibitor nyob rau hauv ib tug emulsification system