Aikace-aikacen HPMC a cikin shiri

1 a matsayin kayan shafa na fim da kayan aikin fim

Yin amfani da hypromellose (HPMC) a matsayin kayan kwalliyar fim ɗin, idan aka kwatanta da allunan gargajiya na gargajiya kamar allunan da aka yi da sukari, allunan da aka rufe ba su da fa'ida a bayyane a cikin masking ɗanɗanon magani da bayyanar, amma taurinsu da friability , ɗaukar danshi, tarwatsewa, ɗaukar nauyi riba da sauran alamun inganci sun fi kyau.Ana amfani da ƙarancin danko na wannan samfurin azaman kayan shafa na ruwa mai narkewa don allunan da kwaya, kuma ana amfani da madaidaicin madaidaicin a matsayin kayan kwalliyar fim don tsarin narkewar ƙwayoyin cuta.Matsakaicin yawanci shine 2.0% zuwa 20%.

2 a matsayin mai ɗaure da tarwatsewa

Za'a iya amfani da ƙarancin danko na wannan samfurin azaman mai ɗaure da rarrabuwa don allunan, kwaya, da granules, kuma babban ma'aunin danko kawai za'a iya amfani dashi azaman mai ɗaure.Matsakaicin ya bambanta da samfura da buƙatu daban-daban.Gabaɗaya, adadin abin ɗaure don busassun busassun granulation shine 5%, kuma sashi na ɗaure don allunan granulation shine 2%.

3 a matsayin wakili mai dakatarwa

Wakilin da aka dakatar shine wani abu mai danko mai danko tare da hydrophilicity, wanda zai iya rage saurin sedimentation na barbashi lokacin da aka yi amfani da shi a cikin wakili mai dakatarwa, kuma ana iya haɗa shi zuwa saman sassan don hana barbashi daga haɗuwa da raguwa a cikin ball. .Wakilan da aka dakatar suna taka muhimmiyar rawa wajen yin dakatarwa.HPMC ne mai kyau iri-iri na dakatar jamiái, da kuma ta narkar da colloidal bayani iya rage tashin hankali na ruwa-m dubawa da kuma free makamashi a kan kananan m barbashi, game da shi inganta kwanciyar hankali na iri-iri watsawa tsarin.Ana amfani da babban darajar wannan samfur azaman shiri-nau'in ruwa wanda aka shirya azaman wakili mai dakatarwa.Yana da tasiri mai kyau na dakatarwa, yana da sauƙin sakewa, baya tsayawa a bango, kuma yana da ƙananan ƙwayoyin cuta.Matsakaicin adadin yau da kullun shine 0.5% zuwa 1.5%.

4 a matsayin mai toshewa, wakili mai ɗorewa da wakili mai haifar da pore

Ana amfani da babban ma'aunin danko na wannan samfurin don shirya allunan ci gaba na hydrophilic gel matrix, masu katsewa da wakilai-saki don allunan abubuwan da aka haɗa-saki matrix, kuma yana da tasirin jinkirta sakin miyagun ƙwayoyi.Yawan amfani da shi shine 10% ~ 80% (W / W).Ana amfani da ma'auni mai ƙarancin danko azaman wakilai masu haifar da pore don ci gaba-saki ko shirye-shiryen sakin sarrafawa.Matsakaicin farko da ake buƙata don tasirin warkewa na wannan nau'in kwamfutar hannu za a iya samu da sauri, sannan kuma aiwatar da ci gaba-saki-saki-saki-saki, kuma ana kiyaye tasirin magungunan jini mai inganci a cikin jiki.Lokacin da hypromellose ya hadu da ruwa, yana yin ruwa don samar da gel Layer.Tsarin sakin miyagun ƙwayoyi daga kwamfutar hannu na matrix ya haɗa da yaduwa na gel Layer da yashwar gel Layer.

5 a matsayin manne mai kauri da colloidal

Lokacin da aka yi amfani da wannan samfurin azaman thickener, yawan amfani da taro shine 0.45% ~ 1.0%.Wannan samfurin kuma zai iya ƙara kwanciyar hankali na manne hydrophobic, samar da colloid mai karewa, hana barbashi daga agglomerating da agglomerating, ta haka ne ya hana samuwar laka, kuma taro na yau da kullun shine 0.5% ~ 1.5%.

6 a matsayin capsule abu

Yawancin lokaci capsule harsashi capsule abu na capsule yana dogara ne akan gelatin.Tsarin samar da harsashi na capsule gelatin abu ne mai sauƙi, amma akwai wasu matsaloli da al'amura kamar rashin kariya daga danshi da magungunan oxygen, ƙarancin narkewar ƙwayoyi, da jinkirta tarwatsewar harsashin capsule yayin ajiya.Sabili da haka, ana amfani da hypromellose, a matsayin maye gurbin gelatin capsules, a cikin shirye-shiryen capsules, wanda ke inganta haɓakawa da amfani da tasirin capsules, kuma an inganta shi sosai a gida da waje.

7 a matsayin bioadhesive

Fasahar bioadhesion, yin amfani da abubuwan haɓakawa tare da polymers na bioadhesive, ta hanyar mannewa ga mucosa na ilimin halitta, yana haɓaka ci gaba da ƙulla hulɗar da ke tsakanin shirye-shiryen da mucosa, don haka an saki miyagun ƙwayoyi a hankali kuma a shayar da mucosa don cimma manufar warkewa.A halin yanzu ana amfani da shi sosai Ana amfani da shi don magance cututtuka na kogon hanci, mucosa na baki da sauran sassa.Fasahar bioadhesion na hanji wani sabon tsarin isar da magunguna ne da aka haɓaka a cikin 'yan shekarun nan.Ba wai kawai yana tsawaita lokacin zama na shirye-shiryen magunguna a cikin ƙwayar gastrointestinal ba, amma kuma yana inganta aikin hulɗar tsakanin miyagun ƙwayoyi da membrane tantanin halitta a wurin sha, yana canza launin ruwan kwayar halitta, Inganta shigar da miyagun ƙwayoyi zuwa cikin hanji. Kwayoyin epithelial, don haka inganta bioavailability na miyagun ƙwayoyi.

8 a matsayin Gel

A matsayin shirye-shiryen m don fata, gel yana da jerin fa'idodi irin su aminci, kyakkyawa, tsaftacewa mai sauƙi, ƙananan farashi, tsari mai sauƙi na shirye-shirye, da kuma dacewa mai kyau tare da kwayoyi.hanya.

9 a matsayin mai hana lalatawa a cikin tsarin emulsification