IHydroxypropylmethylcellulose (HPMC) iyi-polymer esebenzayo esetshenziswa kabanzi kwezemithi, ukudla, izimonyo, kanye nezinhlelo zokusebenza ezahlukahlukene zezimboni.Ukusebenza kwayo kuhlobene eduze nezakhiwo zayo ze-viscosity, ezidlala indima ebalulekile ekunqumeni ukusebenza kwayo ekwakhiweni okuhlukahlukene.Le ndatshana ibheka ukubaluleka kwe-viscosity ekusebenzeni kwe-HPMC, idingida umthelela wayo ezimpahleni ezibalulekile njengokujiya, i-gelling, ukwakheka kwefilimu, nokukhululwa okuqhubekayo.
IHydroxypropylmethylcellulose (HPMC) i-semi-synthetic polymer etholakala ku-cellulose futhi yalungiswa ngokusabela kwamakhemikhali.Inezinhlobonhlobo zezicelo ngenxa yezakhiwo zayo eziyingqayizivele, kufaka phakathi ukuncibilika kwamanzi, ikhono lokwenza ifilimu kanye nemvelo engeyona i-ionic.Phakathi kwezakhiwo zayo ezihlukahlukene, i-viscosity iyipharamitha eyinhloko ethinta ukusebenza kwayo ezinhlelweni ezahlukene.
1.HPMC umsebenzi we-viscosity:
1.1 Ukuqina:
Omunye wemisebenzi eyinhloko ye-HPMC ekwenziweni okuningi ukujiya.I-viscosity yesisombululo se-HPMC ihlobene ngokuqondile nekhono layo lokwandisa i-viscosity ye-medium ezungezile.I-viscosity ephakeme amamaki e-HPMC avame ukusetshenziswa ekuqiniseni izinhlelo ezifana namapende, izinto ezinamathelayo kanye nemikhiqizo yokunakekelwa komuntu siqu.Umphumela wokujiya uphumela ekhonweni le-polymer ukugoqa futhi yakhe inethiwekhi ngaphakathi kwe-solvent, ngaleyo ndlela ivimbe ukugeleza kwendawo ephakathi.
1.2 I-Gelling:
Ngaphezu kokuqina, i-HPMC ingaphinda ibonise izakhiwo ze-gelling ngaphansi kwezimo ezithile.Ukuziphatha kwe-gelation kuhlobene eduze ne-viscosity yesisombululo se-HPMC.Amabanga aphezulu e-viscosity avame ukwakha ama-gel aqinile futhi abe nokuzinza okukhulu.I-Gelation ibaluleke kakhulu ekwenziweni kwemithi, lapho i-HPMC isetshenziselwa ukudala ama-matrics akhishwa okulawulwayo noma ukunikeza i-viscosity kumajeli we-topical namafutha okugcoba.
1.3 Ukwakhiwa kwefilimu:
I-HPMC isetshenziswa kakhulu ekwakhiweni kwezimbotshana, amafilimu kanye ne-encapsulation ngenxa yamakhono ayo okwenza ifilimu.I-viscosity yesisombululo se-HPMC ithinta kakhulu inqubo yokwakhiwa kwefilimu.Kuzinhlelo zokusebenza ezidinga amafilimu aminyene anamandla angcono emishini kanye nezakhiwo zokuthibela, amamaki e-viscosity aphezulu ayakhethwa.Ukwakhiwa kwamafilimu aqhubekayo afanayo kuncike ku-viscosity yesisombululo se-polymer kanye nekhono layo lokusabalalisa ngokulinganayo ku-substrate.
1.4 Ukukhishwa okuzinzile:
Ekwakhekeni kwemithi, i-HPMC ivamise ukusetshenziswa njengeyangaphambili ye-matrix kumafomu omthamo wokukhishwa olawulwayo.Izinga lokukhululwa kwesithako esisebenzayo kusuka ku-matrix lithintwa yi-viscosity yesisombululo se-HPMC.Amabanga aphezulu e-viscosity aphumela kumazinga okukhululwa kancane kusukela ku-matrix ngenxa yokuthi ukusakazeka kwama-molecule ezidakamizwa nge-polymer matrix evuvukele kuyavinjelwa.Lokhu kunika amandla ukwakhiwa kwamafomu omthamo wokukhishwa okuqhubekayo anamaphrofayela anwetshiwe okukhishwa kwezidakamizwa.
2. Izinto ezithinta i-HPMC viscosity:
Kunezici ezimbalwa ezingathinta i-viscosity yezixazululo ze-HPMC, kufaka phakathi:
Isisindo samangqamuzana: Isisindo samangqamuzana aphezulu amamaki e-HPMC ngokuvamile abonisa ama-viscosity aphezulu ngenxa yokwanda kweketango.
Izinga lokushintsha: Izinga lokushintshwa kwe-hydroxypropyl namaqembu e-methyl kuketango eliyinhloko le-cellulose lithinta ukuncibilika kanye ne-viscosity ye-HPMC.
Ukugxila: I-viscosity yezixazululo ze-HPMC ngokuvamile iyanda ngokugxila kwe-polymer ebudlelwaneni obungewona umugqa.
Izinga lokushisa: I-Viscosity ihlobene nezinga lokushisa.Uma izinga lokushisa liphezulu, i-viscosity izokwehla ngenxa yokunciphisa ukuxhumana phakathi kwe-polymer ne-solvent.
I-pH namandla e-ionic: Izinguquko ku-pH namandla e-ionic zingashintsha ukuncibilika kanye ne-viscosity ye-HPMC ngokusebenzisa i-ionization kanye nemiphumela eyinkimbinkimbi.
3. Lawula i-viscosity ye-HPMC:
Abakhiqizi bangakwazi ukulawula i-viscosity yezixazululo ze-HPMC ukuze bathole imiphumela efiselekayo kuzinhlelo zokusebenza ezihlukahlukene:
Ukukhethwa kwamabanga e-HPMC: Amabanga ahlukene e-HPMC ayatholakala ngama-viscosity ahlukene ukuze ahlangabezane nezidingo ezithile zokwakheka.
Ukuxutshwa namanye ama-polymer: Ukuhlanganisa i-HPMC namanye ama-polymer noma izithasiselo kungashintsha i-viscosity yayo futhi kuthuthukise ukusebenza kwayo.
Lungisa Ukugxila: Ukulawula ukugxila kwe-HPMC ekwakhiweni kuvumela ukulungiswa okunembile kwe-viscosity.
Ukulawula izinga lokushisa: Ukulawula izinga lokushisa kungasetshenziswa ukulungisa i-viscosity yesisombululo se-HPMC ngesikhathi sokucubungula.
I-pH kanye nokulungiswa kwamandla e-ionic: Ukushintsha i-pH namandla e-ionic okwakheka kungathinta ukunyibilika kanye ne-viscosity ye-HPMC.
I-Viscosity idlala indima ebalulekile ekuvimbeleni ukusebenza kwe-HPMC kuhlelo olubanzi lwezinhlelo zokusebenza.Ukuqonda ubudlelwano phakathi kwe-viscosity nokusebenza kwe-HPMC kubalulekile kubadidiyeli ukuze bakhe ukwakheka okuphumelelayo.Ngokukhetha ngokucophelela amabanga e-HPMC nokulawula i-viscosity ngamasu ahlukahlukene, abakhi bangakwazi ukuthuthukisa ukusebenza komkhiqizo futhi bahlangabezane nezimfuneko ezithile zohlelo lokusebenza.
Isikhathi sokuthumela: Feb-29-2024