Hydroxypropylmethylcellulose (HPMC) i polymer inoshanda yakawanda inoshandiswa zvakanyanya mumishonga, chikafu, zvizorwa, uye akasiyana maindasitiri ekushandisa.Kushanda kwayo kunoenderana zvakanyanya neayo viscosity zvimiro, izvo zvinotora basa rakakosha pakuona kuita kwayo mukuumbwa kwakasiyana.Ichi chinyorwa chinoongorora kukosha kwe viscosity mukushanda kweHPMC, kukurukura maitiro ayo pazvinhu zvakakosha zvakaita sekukora, gelling, kuumbwa kwemafirimu, uye kusunungurwa kwakasimba.
Hydroxypropylmethylcellulose (HPMC) is a semi-synthetic polymer inotorwa kubva muselulosi uye yakagadziridzwa kuburikidza nekuita kwemakemikari.Iyo ine huwandu hwakawanda hwekushandisa nekuda kweiyo yakasarudzika midziyo, kusanganisira kunyungudika kwemvura, kugona kugadzira firimu uye isiri-ionic hunhu.Pakati pezvimiro zvayo zvakasiyana, viscosity ndiyo yakakosha parameter inokanganisa mashandiro ayo mumashandisirwo akasiyana.
1.HPMC viscosity basa:
1.1 Kuwedzera:
Rimwe remabasa ekutanga eHPMC mune akawanda maumbirwo ari kukora.Iyo viscosity yeHPMC mhinduro yakanangana nekugona kwayo kuwedzera viscosity yepakati yakatenderedza.Yepamusoro viscosity HPMC mamakisi anowanzo shandiswa mukukora zvikumbiro senge pendi, zvinonamira uye zvigadzirwa zvekuchengeta munhu.Iko kukora mhedzisiro kunobva mukugona kwepolymer kupinza uye kugadzira network mukati meiyo solvent, zvichizokanganisa kuyerera kwepakati.
1.2 Gelling:
Pamusoro pekukora, HPMC inogona zvakare kuratidza gelling zvivakwa pasi pemamwe mamiriro.Iyo gelation maitiro ane hukama zvakanyanya kune viscosity yeHPMC mhinduro.Yepamusoro viscosity mamakisi anowanzo kuumba gel akasimba uye ane kugadzikana kukuru.Gelation inonyanya kukosha mukugadzirwa kwemishonga, uko HPMC inoshandiswa kugadzira matrices anodzorwa-anoburitswa kana kupa viscosity mune topical gels uye mafuta ekuzora.
1.3 Kugadzira firimu:
HPMC inoshandiswa zvakanyanya mukugadzira machira, mafirimu uye encapsulation nekuda kwekugona kwayo kugadzira firimu.Iyo viscosity yeHPMC mhinduro inokanganisa zvakanyanya maitiro ekugadzira firimu.Kune maapplication anoda mafirimu akakora ane simba remuchina uye zvipingamupinyi zvivakwa, mamakisi epamusoro eviscosity anosarudzwa.Kuumbwa kwemafirimu anoramba achiita mayunifomu kunoenderana nekuona kwepolymer mhinduro uye kugona kwayo kupararira zvakaenzana pane substrate.
1.4 Kuburitswa kwakasimba:
Mukugadzirwa kwemishonga, HPMC inowanzo shandiswa sematrix yakambodzora mafomu ekuburitsa dosage.Kuburitswa kwechigadzirwa chinoshanda kubva kumatrix chinokanganiswa ne viscosity yeHPMC mhinduro.Akakwira viscosity mamakisi anokonzeresa kunonoka kuburitsa mitengo kubva kumatrix nekuti kupararira kwemamorekuru emishonga kuburikidza nekuzvimba kwepolymer matrix kunodzivirirwa.Izvi zvinogonesa kugadzirwa kwemafomu ekuramba-kuburitswa kwedosi ane akawedzera kuburitswa kwemishonga.
2. Zvinhu zvinokanganisa HPMC viscosity:
Zvinhu zvakati wandei zvinogona kukanganisa viscosity yeHPMC mhinduro, kusanganisira:
Molecular Weight: Yepamusoro mamorekuru uremu HPMC mamakisi anowanzo ratidza akakwira viscosities nekuda kwekuwedzera ketani entanglement.
Dhigirii rekutsiva: Iyo dhigirii yekutsiva hydroxypropyl uye methyl mapoka pane cellulose main cheni inokanganisa kunyungudika uye viscosity yeHPMC.
Concentration: Iyo viscosity yeHPMC mhinduro inowanzowedzera nekuwedzera polymer kusungwa muhukama husina-mutsara.
Tembiricha: Viscosity inoenderana nekushisa.Iyo yakakwirira tembiricha, viscosity inodzikira nekuda kwekuderera kwekudyidzana pakati pepolymer uye solvent.
pH uye ionic simba: Shanduko mupH uye ionic simba inogona kushandura solubility uye viscosity yeHPMC kuburikidza neionization uye yakaoma mhedzisiro.
3. Kudzora HPMC viscosity:
MaFormulators anogona kudzora viscosity yeHPMC mhinduro kuti uwane mhedzisiro inodiwa mumhando dzakasiyana dzekushandisa:
Kusarudzwa kwemagiredhi eHPMC: Magiredhi akasiyana eHPMC anowanikwa aine maviscosities akasiyana kuti asangane nezvinodiwa zvekugadzira.
Kusanganisa nemamwe mapolymer: Kusanganisa HPMC nemamwe mapolymer kana zvinowedzera zvinogona kushandura viscosity yayo uye kuwedzera mashandiro ayo.
Gadzirisa Concentration: Kudzora kusungirirwa kweHPMC mukugadzirisa kunobvumira kunyatsogadziriswa kwe viscosity.
Kudzora tembiricha: Kudzora tembiricha inogona kushandiswa kugadzirisa viscosity yeHPMC mhinduro panguva yekugadzirisa.
pH uye ionic simba rekugadzirisa: Kuchinja iyo pH uye ionic simba rekugadzira kunogona kukanganisa solubility uye viscosity yeHPMC.
Viscosity inobata basa rakakosha mukuvharidzira kushanda kweHPMC mune zvakasiyana siyana zvekushandisa.Kunzwisisa hukama pakati peviscosity uye HPMC kuita kwakakosha kune vanogadzira kugadzira maumbirwo anoshanda.Nekunyatsosarudza mamakisi eHPMC uye kudzora viscosity kuburikidza neakasiyana mazano, vagadziri vanogona kukwidziridza kuita kwechigadzirwa uye kusangana nezvinodiwa zvekushandisa.
Nguva yekutumira: Feb-29-2024