Hydroxypropylmethylcellulose (HPMC) yog ib qho khoom siv polymer uas siv dav hauv cov tshuaj, khoom noj, tshuaj pleev ib ce, thiab ntau yam kev siv hauv kev lag luam.Nws cov functionality yog ze ze rau nws cov viscosity zog, uas ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab nws cov kev ua tau zoo hauv cov qauv sib txawv.Kab lus no tshawb txog qhov tseem ceeb ntawm viscosity hauv HPMC kev ua haujlwm, sib tham txog nws qhov cuam tshuam rau cov khoom tseem ceeb xws li thickening, gelling, tsim cov yeeb yaj kiab, thiab kev tso tawm mus tas li.
Hydroxypropylmethylcellulose (HPMC) yog ib tug semi-synthetic polymer muab los ntawm cellulose thiab hloov los ntawm ib tug tshuaj tiv thaiv.Nws muaj ntau yam kev siv vim nws cov khoom tshwj xeeb, suav nrog cov dej solubility, kev ua yeeb yaj kiab muaj peev xwm thiab cov xwm txheej uas tsis yog-ionic.Ntawm nws cov khoom sib txawv, viscosity yog qhov tseem ceeb uas cuam tshuam rau nws txoj haujlwm hauv kev siv sib txawv.
1.HPMC viscosity muaj nuj nqi:
1.1 Thickening:
Ib qho ntawm cov haujlwm tseem ceeb ntawm HPMC hauv ntau cov qauv yog thickening.Lub viscosity ntawm HPMC cov tshuaj yog ncaj qha ntsig txog nws lub peev xwm los ua kom cov viscosity ntawm qhov nruab nrab ib puag ncig.Cov qib viscosity siab dua HPMC feem ntau yog siv rau hauv cov ntaub ntawv tuab xws li cov xim, cov nplaum thiab cov khoom tu tus kheej.Cov nyhuv thickening tshwm sim los ntawm lub peev xwm ntawm cov polymer mus rau entangle thiab tsim ib lub network nyob rau hauv cov kuab tshuaj, yog li impeding lub ndlwg ntawm nruab nrab.
1.2 Kev hloov pauv:
Ntxiv rau qhov thickening, HPMC kuj tuaj yeem pom cov khoom gelling nyob rau hauv qee yam mob.Tus cwj pwm gelation yog ze ze rau qhov viscosity ntawm HPMC tov.Cov qib viscosity siab dua yuav ua rau cov gels muaj zog dua thiab muaj kev ruaj khov dua.Gelation yog ib qho tseem ceeb tshwj xeeb hauv cov tshuaj formulations, qhov twg HPMC yog siv los tsim tswj-tso matrices los yog muab viscosity nyob rau hauv tshuaj pleev ib ce thiab tshuaj pleev.
1.3 Zaj duab xis tsim:
HPMC yog siv dav hauv kev tsim cov txheej txheem, cov yeeb yaj kiab thiab cov encapsulation vim nws lub peev xwm ua yeeb yaj kiab.Lub viscosity ntawm HPMC cov tshuaj cuam tshuam rau cov txheej txheem tsim cov yeeb yaj kiab.Rau cov ntawv thov uas xav tau cov yeeb yaj kiab tuab nrog cov khoom siv zoo dua qub thiab cov khoom thaiv, cov qib viscosity siab dua yog nyiam.Kev tsim cov yeeb yaj kiab tsis tu ncua yog nyob ntawm qhov viscosity ntawm cov tshuaj polymer thiab nws lub peev xwm sib kis tusyees ntawm lub substrate.
1.4 Kev tso tawm tsis tu ncua:
Hauv cov tshuaj formulations, HPMC feem ntau yog siv raws li ib tug matrix qub rau cov ntaub ntawv tso tawm ntau npaum li cas.Qhov tso tawm tus nqi ntawm cov khoom xyaw nquag los ntawm matrix yog cuam tshuam los ntawm viscosity ntawm HPMC tov.Cov qib viscosity siab dua ua rau qeeb qeeb tso tawm ntawm cov matrix vim tias kev nthuav tawm ntawm cov tshuaj molecules los ntawm o ntawm polymer matrix yog cuam tshuam.Qhov no tso cai rau cov formulation ntawm sustained-tso tawm cov ntaub ntawv nrog rau ncua kev tso tshuaj profiles.
2. Yam cuam tshuam rau HPMC viscosity:
Ntau yam tuaj yeem cuam tshuam qhov viscosity ntawm HPMC cov kev daws teeb meem, suav nrog:
Molecular Luj: Cov qib molecular hnyav dua HPMC feem ntau pom muaj cov viscosities ntau dua vim muaj cov saw txuas ntxiv.
Degree ntawm kev hloov pauv: Lub degree ntawm kev hloov ntawm hydroxypropyl thiab methyl pawg ntawm cov cellulose lub ntsiab saw muaj feem xyuam rau cov solubility thiab viscosity ntawm HPMC.
Kev Cuam Tshuam: Lub viscosity ntawm HPMC cov kev daws teeb meem feem ntau nce nrog kev ua kom cov polymer concentration hauv kev sib raug zoo uas tsis yog-linear.
Kub: viscosity muaj feem xyuam rau qhov kub thiab txias.Qhov siab dua qhov kub, qhov viscosity yuav txo qis vim kev cuam tshuam ntawm cov polymer thiab cov hnyav.
pH thiab ionic zog: Hloov pH thiab ionic zog tuaj yeem hloov cov solubility thiab viscosity ntawm HPMC los ntawm ionization thiab complexation teebmeem.
3. Tswj HPMC viscosity:
Formulators tuaj yeem tswj cov viscosity ntawm HPMC cov kev daws teeb meem kom ua tiav cov txiaj ntsig xav tau hauv ntau yam kev siv:
Xaiv cov qib HPMC: Cov qib sib txawv ntawm HPMC muaj nrog cov viscosities sib txawv kom tau raws li cov qauv tsim tshwj xeeb.
Kev sib xyaw nrog lwm cov polymers: Kev sib xyaw HPMC nrog lwm cov polymers lossis cov khoom siv ntxiv tuaj yeem hloov nws cov viscosity thiab txhim kho nws txoj haujlwm.
Kho Concentration: Tswj qhov concentration ntawm HPMC nyob rau hauv lub formulation tso cai rau kev hloov kho ntawm viscosity.
Kev tswj qhov kub thiab txias: Kev tswj kub tuaj yeem siv los kho cov viscosity ntawm HPMC cov tshuaj thaum ua haujlwm.
Kev hloov pauv pH thiab ionic zog: Hloov pH thiab ionic lub zog ntawm cov qauv tuaj yeem cuam tshuam rau kev solubility thiab viscosity ntawm HPMC.
Viscosity plays lub luag haujlwm tseem ceeb hauv inhibiting kev ua haujlwm ntawm HPMC hauv ntau hom kev siv.Nkag siab txog kev sib raug zoo ntawm viscosity thiab HPMC kev ua tau zoo yog qhov tseem ceeb rau cov neeg tsim qauv tsim cov qauv tsim tau zoo.Los ntawm kev ua tib zoo xaiv cov qib HPMC thiab tswj cov viscosity los ntawm ntau lub tswv yim, cov neeg tsim khoom tuaj yeem ua kom zoo dua cov khoom lag luam thiab ua tau raws li cov kev cai tshwj xeeb.
Post lub sij hawm: Feb-29-2024