Hydroxypropylmethylcellulose (HPMC) bụ polymer multifunctional nke a na-ejikarị na ọgwụ, nri, ihe ntecha, na ngwa ụlọ ọrụ dị iche iche.Ọrụ ya nwere njikọ chiri anya na njirimara viscosity ya, nke na-arụ ọrụ dị oke mkpa n'ịchọpụta arụmọrụ ya n'ụdị dị iche iche.Edemede a na-enyocha mkpa viscosity dị na arụmọrụ HPMC, na-ekwurịta mmetụta ya na akụrụngwa ndị dị ka ịgba, gelling, nhazi ihe nkiri, na ntọhapụ na-adịgide adịgide.
Hydroxypropylmethylcellulose (HPMC) bụ polymer synthetic ọkara nke ewepụtara na cellulose ma gbanwee site na mmeghachi omume kemịkal.Ọ nwere ọtụtụ ngwa dị iche iche n'ihi ihe ndị pụrụ iche ya, gụnyere mmiri solubility, ike ịmepụta ihe nkiri na ọdịdị na-abụghị ionic.N'ime njirimara ya dị iche iche, viscosity bụ isi ihe na-emetụta ọrụ ya na ngwa dị iche iche.
Ọrụ viscosity 1.HPMC:
1.1 Na-agba ọsọ:
Otu n'ime isi ọrụ nke HPMC na ọtụtụ usoro bụ ndim.The viscosity nke a HPMC ngwọta na-metụtara kpọmkwem ike ya dịkwuo viscosity nke gburugburu gburugburu.A na-ejikarị akara ule viscosity HPMC dị elu na ngwa ndị na-eme mkpụkọ dị ka agba, nrapado na ngwaahịa nlekọta onwe onye.Mmetụta dị nro na-esi na ike nke polymer na-ejikọta na ịmepụta netwọk n'ime ihe mgbaze, si otú ahụ na-egbochi mgbasa nke usoro.
1.2 Ịgba ọsọ:
Na mgbakwunye na ndim, HPMC nwekwara ike igosipụta ihe eji eme gelling n'okpuru ọnọdụ ụfọdụ.Omume gelation nwere njikọ chiri anya na viscosity nke ngwọta HPMC.Ogo viscosity dị elu na-etolite gels siri ike ma nwee nkwụsi ike ka ukwuu.Gelation dị mkpa karịsịa na usoro ọgwụ, ebe a na-eji HPMC emepụta matrices a na-achịkwa ma ọ bụ iji nye viscosity na gels na ointments.
1.3 Nhazi ihe nkiri:
A na-eji HPMC eme ihe n'ọtụtụ ebe n'ụdị mkpuchi, ihe nkiri na mkpuchi n'ihi ike imepụta ihe nkiri ya.Viscosity nke HPMC ngwọta na-emetụta nke ukwuu usoro nhazi ihe nkiri.Maka ngwa na-achọ ihe nkiri gbara ọkpụrụkpụ nke nwere ike arụ ọrụ ka mma yana ihe mgbochi, akara viscosity dị elu na-ahọrọ.Nhazi nke ihe nkiri na-aga n'ihu na-adabere na viscosity nke ngwọta polymer na ikike ya ịgbasa ọbụna na mkpụrụ.
1.4 Ntọhapụ na-adịgide adịgide:
Na usoro ọgwụ, a na-ejikarị HPMC eme ihe dị ka matriks nke bụbu maka ụdị ntọhapụ a na-achịkwa.Ọnụego mwepụta nke ihe na-arụ ọrụ sitere na matriks na-emetụta viscosity nke ngwọta HPMC.Ogo viscosity dị elu na-ebute ọnụego ntọhapụ nwayọ site na matriks n'ihi na a na-egbochi mgbasa nke mkpụrụ ndụ ọgwụ site na matriks polymer fụrụ akpụ.Nke a na-enyere aka ịmepụta ụdị ntọhapụ na-adịgide adịgide yana profaịlụ ntọhapụ ọgwụ agbatị.
2. Ihe na-emetụta viscosity HPMC:
Ọtụtụ ihe nwere ike imetụta viscosity nke ngwọta HPMC, gụnyere:
Arọ Molecular: Akara ule HPMC dị elu na-egosipụtakarị viscosities dị elu n'ihi mmụba n'agbụ agbụ.
Ọkwa nnọchi: ogo nnọchi nke hydroxypropyl na methyl otu na cellulose isi yinye na-emetụta solubility na viscosity nke HPMC.
Ntụkwasị: The viscosity nke HPMC ngwọta n'ozuzu na-abawanye na-abawanye na polymer itinye uche na a na-abụghị linear mmekọrịta.
Okpomọkụ: Viscosity metụtara okpomọkụ.N'ịdị elu nke okpomọkụ, viscosity ga-ebelata n'ihi mbelata mmekọrịta n'etiti polymer na ihe mgbaze.
pH na ike ionic: Mgbanwe na pH na ike ionic nwere ike gbanwee solubility na viscosity nke HPMC site na ionization na mgbagwoju anya mmetụta.
3. Jikwa viscosity HPMC:
Ndị na-emepụta ihe nwere ike ijikwa viscosity nke ngwọta HPMC iji nweta nsonaazụ achọrọ na ngwa dị iche iche:
Nhọrọ nke akara ule HPMC: Akara ule HPMC dị iche iche dị na viscosities dị iche iche iji zute ihe ndị chọrọ nhazi.
Ịgwakọta na ndị ọzọ polymers: Ịgwakọta HPMC na ndị ọzọ polymers ma ọ bụ ihe mgbakwunye nwere ike ịgbanwe ya viscosity na welie ya ọrụ.
Gbanwee ntinye uche: Ịchịkwa mkpokọta HPMC na nhazi ahụ na-enye ohere ngbanwe nke ọma nke viscosity.
Njikwa okpomọkụ: Enwere ike iji njikwa okpomọkụ gbanwee viscosity nke ngwọta HPMC n'oge nhazi.
Mgbanwe pH na ike ionic: Ịgbanwe pH na ike ionic nke nhazi nwere ike imetụta solubility na viscosity nke HPMC.
Viscosity na-arụ ọrụ dị oke mkpa na igbochi ọrụ HPMC n'ọtụtụ ngwa.Ịghọta mmekọrịta dị n'etiti viscosity na arụmọrụ HPMC dị oke mkpa maka ndị na-emepụta ihe iji chepụta usoro dị irè.Site n'iji nlezianya họrọ akara ule HPMC na ịchịkwa viscosity site na atụmatụ dị iche iche, ndị na-emepụta ihe nwere ike ịkwalite arụmọrụ ngwaahịa na izute ihe achọrọ ngwa ngwa.
Oge nzipu: Feb-29-2024