IHydroxypropylmethylcellulose (HPMC) iyinhlanganisela eguquguqukayo esetshenziswa ezimbonini ezahlukahlukene ezihlanganisa ezemithi, ezokudla, ezokwakha nezimonyo.Ukuqonda ukwakheka kwayo, ukwakheka kwayo, izakhiwo kanye nokusetshenziswa kwayo kudinga ukucwaninga okujulile kokwakheka kwamakhemikhali ayo kanye nenqubo yokuhlanganisa.
ukwakheka kanye nesakhiwo
I-Cellulose Backbone: I-HPMC isuselwa ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo.I-Cellulose yakhiwe ngamaketanga amade amayunithi eglucose axhunywe ndawonye ngamabhondi e-β-1,4 glycosidic.
I-Methylation: I-Methylcellulose iyisandulela se-HPMC futhi ikhiqizwa ngokwelapha i-cellulose nge-alkali ne-methyl chloride.Inqubo ihilela ukufaka esikhundleni samaqembu e-hydroxyl (-OH) kumgogodla we-cellulose ngamaqembu e-methyl (-CH3).
I-Hydroxypropylation: Ngemva kwe-methylation, i-hydroxypropylation ivela.Kulesi sinyathelo, i-propylene oxide isabela nge-methylated cellulose, yethula amaqembu e-hydroxypropyl (-OCH2CHOHCH3) kumgogodla we-cellulose.
I-Degree of Substitution (DS): Izinga lokushintsha libhekisela enanini elimaphakathi le-hydroxypropyl namaqembu e-methyl ngeyunithi ngayinye ye-glucose ochungechungeni lwe-cellulose.Le pharamitha ithinta izici ze-HPMC, okuhlanganisa ukunyibilika kwayo, i-viscosity, nokuziphatha okushisayo.
ukuhlanganisa
Ukwelashwa kwe-alkaline: Imicu ye-Cellulose iqala ukuphathwa ngesisombululo se-alkaline, ngokuvamile i-sodium hydroxide (NaOH), ukunqamula amabhondi e-hydrogen e-intermolecular futhi andise ukufinyeleleka kwamaqembu e-cellulose hydroxyl.
I-Methylation: I-Cellulose ephathwa nge-alkali isabela nge-methyl chloride (CH3Cl) ngaphansi kwezimo ezilawulwayo, okuholela ekushintshweni kwamaqembu e-hydroxyl ngamaqembu e-methyl.
I-Hydroxypropylation: I-Methylated cellulose iphinde ihlangane ne-propylene oxide (C3H6O) phambi kwe-catalyst efana ne-sodium hydroxide.Lokhu kusabela kwethula amaqembu e-hydroxypropyl kumgogodla we-cellulose.
I-Neutralization and Purification: Yenza kungabi phakathi inhlanganisela yokusabela ukuze ususe noma isiphi isisekelo eseqile.Umkhiqizo otholiwe ungena ezinyathelweni zokuhlanzwa ezinjengokuhlunga, ukuwashwa, nokomiswa ukuze kutholwe umkhiqizo wokugcina we-HPMC.
isici
Ukunyibilika: I-HPMC iyancibilika emanzini futhi yenza isixazululo esicacile, esibonakalayo.Ukuncibilika kuncike ezintweni ezifana nezinga lokushintshwa, isisindo samangqamuzana, nezinga lokushisa.
I-Viscosity: Izixazululo ze-HPMC zibonisa ukuziphatha kwe-pseudoplastic, okusho ukuthi i-viscosity yazo iyancipha ngokunyuka kwezinga lokugunda.I-viscosity ingalawulwa ngokulungisa amapharamitha afana ne-DS, isisindo samangqamuzana nokugxila.
Ukwakhiwa Kwefilimu: I-HPMC yenza amafilimu aguquguqukayo nasobala lapho esakazwa kusixazululo sawo esimanzi.Lawa mafilimu athola izinhlelo zokusebenza kuma-coatings, emaphaketheni nakumakhemisi.
Ukuzinza Kwe-Thermal: I-HPMC izinzile ngokwezinga lokushisa elithile, ngaphezu kwalokho ukonakala kwenzeka.Ukuzinza kokushisa kuncike ezintweni ezifana ne-DS, umswakama, kanye nokuba khona kwezithasiselo.
Izindawo zokufaka izicelo
Ezemithi: I-HPMC isetshenziswa kakhulu ekwenziweni kwemithi njengama-thieners, ama-binders, ama-ejenti akhiqiza amafilimu kanye no-matrics abakhululwa okuqhubekayo.Ithuthukisa ukuhlakazeka kwethebhulethi, ukuhlakazeka kanye ne-bioavailability.
Ukudla: Embonini yokudla, i-HPMC isetshenziswa njenge-thickener, stabilizer, emulsifier kanye nesigcwalisi emikhiqizweni efana namasoso, okokugqoka, izimpahla ezibhakwayo nemikhiqizo yobisi.
Ukwakhiwa: I-HPMC yengezwa odakeni olusekelwe kusimende, i-stucco ne-adhesives yamathayela ukuze kuthuthukiswe ukusebenza, ukugcinwa kwamanzi nokunamathela.Ithuthukisa ukusebenza kwalezi zinto zokwakha ezimweni ezihlukahlukene.
Izimonyo: I-HPMC isetshenziswa njenge-thickener, emulsifier kanye ne-stabilizer ekwakhiweni kwezimonyo ezifana nokhilimu, izinto zokuthambisa kanye namajeli.Inikeza izici ezifiselekayo ze-rheological futhi ithuthukise ukuzinza komkhiqizo.
IHydroxypropyl methylcellulose (HPMC) iyinhlanganisela esebenza ngezindlela eziningi ehlanganiswe ku-cellulose ngezinqubo ze-methylation kanye ne-hydroxypropylation.Ukwakheka kwayo kwamakhemikhali, izakhiwo kanye nokusetshenziswa kwayo kuyenza ibe yisithako esibalulekile ezimbonini ezihlukene njengezemithi, ukudla, ukwakhiwa kanye nezimonyo.Ucwaningo olwengeziwe nokuthuthukiswa kobuchwepheshe be-HPMC luyaqhubeka nokwandisa izinhlelo zokusebenza ezingase lube khona futhi luthuthukise ukusebenza kwalo ekwenziweni okuhlukahlukene.
Isikhathi sokuthumela: Feb-20-2024