Hydroxypropylmethylcellulose (HPMC) bụ ngwakọta dị iche iche eji arụ ọrụ dị iche iche gụnyere ọgwụ, nri, ihe owuwu na ihe ịchọ mma.Ịghọta ihe mejupụtara ya, nhazi ya, ihe onwunwe na ngwa na-achọ nyocha miri emi nke usoro kemịkalụ ya na nhazi ya.
mejupụtara na nhazi
Ọkpụkpụ azụ Cellulose: HPMC sitere na cellulose, polymer eke dị na mgbidi cell osisi.Ihe mejupụtara cellulose bụ ogologo agbụ nke nkeji glucose jikọtara ọnụ site na njikọ β-1,4 glycosidic.
Methylation: Methylcellulose bụ ihe mbụ na HPMC ma na-emepụta ya site na ịgwọ cellulose na alkali na methyl chloride.Usoro a gụnyere iji dochie otu hydroxyl (-OH) na ọkpụkpụ azụ cellulose na otu methyl (-CH3).
Hydroxypropylation: Mgbe methylation gasịrị, hydroxypropylation na-eme.N'ime usoro a, propylene oxide na-emeghachi omume na cellulose methylated, na-ewebata otu hydroxypropyl (-OCH2CHOHCH3) na ọkpụkpụ azụ cellulose.
Degree of nnọchi (DS): Ogo nke nnọchi na-ezo aka na nkezi ọnụọgụ hydroxypropyl na methyl otu glucose n'ime agbụ cellulose.Oke a na-emetụta akụrụngwa nke HPMC, gụnyere solubility ya, viscosity na omume okpomọkụ.
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Ọgwụgwọ alkaline: A na-ebu ụzọ agwọ eriri cellulose na ngwọta alkaline, nke na-abụkarị sodium hydroxide (NaOH), iji mebie njikọ nke hydrogen intermolecular na ịbawanye ohere nke otu cellulose hydroxyl.
Methylation: Cellulose a na-emeso ya na alkali na-emeghachi omume na methyl chloride (CH3Cl) n'okpuru ọnọdụ a na-achịkwa, na-eme ka ndị otu methyl dochie otu hydroxyl.
Hydroxypropylation: Methylated cellulose na-emeghachi omume na propylene oxide (C3H6O) n'ihu ihe na-eme ihe dị ka sodium hydroxide.Mmeghachi omume a na-ewebata otu hydroxypropyl n'ime ọkpụkpụ azụ cellulose.
Neutralization na Ịdị Ọcha: Kwụsị ngwakọta mmeghachi omume iji wepụ isi ihe ọ bụla.Ngwaahịa enwetara na-enweta usoro nchacha dị ka nzacha, ịsa na ihicha iji nweta ngwaahịa HPMC ikpeazụ.
njirimara
Solubility: HPMC bụ soluble n'ime mmiri ma mepụta ngwọta doro anya, viscous.Solubility na-adabere n'ihe ndị dị ka ogo nke nnọchi, ịdị arọ molecular, na okpomọkụ.
Viscosity: Ihe ngwọta HPMC na-egosipụta omume pseudoplastic, nke pụtara na viscosity ha na-ebelata na ọnụ ọgụgụ shear na-abawanye.Enwere ike ịchịkwa viscosity site na ịhazigharị paramita dị ka DS, arọ molecular na itinye uche.
Nhazi ihe nkiri: HPMC na-etolite ihe nkiri na-agbanwe agbanwe na nke doro anya mgbe a na-etinye ya na ngwọta mmiri.Ihe nkiri ndị a na-achọta ngwa na mkpuchi, nkwakọ ngwaahịa na ọgwụ.
Thermal Stability: HPMC kwụsiri ike na okpomọkụ, n'elu nke mmebi na-apụta.Nkwụsi ike okpomọkụ dabere na ihe ndị dị ka DS, ọdịnaya mmiri, na ọnụnọ nke mgbakwunye.
Mpaghara ngwa
Pharmaceuticals: A na-eji HPMC n'ọtụtụ ebe n'ụdị ọgwụ dị ka ndị na-ekpu mmiri, ndị na-ekekọta ihe, ndị na-emepụta ihe nkiri na matrices na-ewepụta.Ọ na-eme ka mbadamba nkume gbasaa, mgbasa na bioavailability.
Nri: N'ụlọ ọrụ nri, a na-eji HPMC eme ihe dị ka thickener, stabilizer, emulsifier na filler na ngwaahịa ndị dị ka sauces, akwa akwa, ngwaahịa esiri esi na ngwaahịa mmiri ara ehi.
Ihe owuwu: A na-agbakwunye HPMC na ụrọ ndị sitere na ciment, stucco na adhesives tile iji melite arụmọrụ, njide mmiri na nrapanye.Ọ na-eme ka arụ ọrụ nke ihe owuwu ụlọ ndị a dị mma na ọnọdụ dị iche iche.
Ihe ịchọ mma: A na-eji HPMC eme ihe dị ka thickener, emulsifier na stabilizer n'ụdị ihe ịchọ mma dị ka ude, lotions na gels.Ọ na-enye akụrụngwa rheological na-achọsi ike ma na-eme ka nkwụsi ike ngwaahịa.
Hydroxypropyl methylcellulose (HPMC) bụ ngwakọta multifunctional arụpụtara site na cellulose site na usoro methylation na hydroxypropylation.Ọdịdị kemịkal ya, ihe onwunwe na ngwa ya na-eme ka ọ bụrụ ihe bara uru na ụlọ ọrụ dị iche iche dị ka ọgwụ, nri, ihe owuwu na ihe ịchọ mma.Nnyocha ọzọ na mmepe nke teknụzụ HPMC na-aga n'ihu na-amụba ngwa ndị nwere ike ime ma melite arụmọrụ ya n'ụdị dị iche iche.
Oge nzipu: Feb-20-2024