O le Hydroxypropylmethylcellulose (HPMC) ose fa'aogaina tele e fa'aaogaina i pisinisi eseese e aofia ai vaila'au, mea'ai, faufale ma mea teuteu.O le malamalama i lona tu'ufa'atasiga, fausaga, meatotino ma fa'aoga e mana'omia ai se su'esu'ega loloto o lona fa'aaupuga o vaila'au ma le fa'agasologa o le fa'asologa.
fatuga ma fausaga
Cellulose Backbone: O le HPMC e maua mai i le cellulose, o se polymer masani e maua i totonu o puipui o laau.O le cellulose e fausia i filifili uumi o iunite kulukose e feso'ota'i fa'atasi e fusi β-1,4 glycosidic.
Methylation: Methylcellulose o se mea muamua i le HPMC ma e gaosia e ala i le togafitia o le cellulose i le alkali ma le methyl chloride.O le faagasologa e aofia ai le suia o vaega hydroxyl (-OH) i luga o le cellulose backbone ma methyl (-CH3) vaega.
Hydroxypropylation: A maeʻa le methylation, e tupu le hydroxypropylation.I lenei laʻasaga, o le propylene oxide e tali atu i le methylated cellulose, faʻafeiloaʻi hydroxypropyl (-OCH2CHOHCH3) vaega i luga o le cellulose backbone.
Degree of Substitution (DS): O le tikeri o le suitulaga e faasino i le averesi numera o hydroxypropyl ma methyl vaega i le kulukose iunite i le filifili cellulose.O lenei parakalafa e a'afia ai meatotino a le HPMC, e aofia ai lona solubility, viscosity, ma amioga vevela.
tuufaatasia
Togafitiga Alkaline: O alava cellulose e muamua togafitia i se vaifofo alkaline, e masani lava o le sodium hydroxide (NaOH), e motusia ai sootaga o le hydrogen intermolecular ma faateleina ai le avanoa o vaega o le cellulose hydroxyl.
Methylation: O le cellulose e togafitia i le alkali e tali atu i le methyl chloride (CH3Cl) i lalo o tulaga pulea, e mafua ai le suia o vaega hydroxyl ma vaega methyl.
Hydroxypropylation: Methylated cellulose e toe tali atu i le propylene oxide (C3H6O) i le i ai o se faʻamalosi e pei o le sodium hydroxide.O le tali lea e fa'aofia ai vaega hydroxypropyl i totonu ole ponaivi o le cellulose.
Fa'amama ma Fa'amamāina: Fa'amama le fa'afefiloiga tali e aveese ai so'o se fa'avae tele.O le oloa na maua e faia ni laasaga faʻamamaina e pei o le faʻamamaina, fufuluina, ma faʻamago e maua ai le oloa mulimuli HPMC.
uiga
Soluble: HPMC e solu i le vai ma fai ai se vaifofo manino, viscous.O le solubility e fa'alagolago i mea e pei o le tikeri o le suia, mamafa mole, ma le vevela.
Viscosity: O vaifofo HPMC o lo'o fa'aalia uiga fa'afoliga, o lona uiga e fa'aitiitia le viscosity i le fa'ateleina o le sile.Viscosity e mafai ona pulea e ala i fetuutuunai tapulaʻa pei o le DS, mole mamafa ma le faʻatonuga.
Fuaina o Ata: HPMC e fa'atupu ata fe'avea'i ma manino pe a lafo mai lona vai vai.O nei ata tifaga e maua ai faʻaoga i faʻalavalava, afifiina ma vailaʻau.
Mauaina Fa'avela: HPMC e fa'amautu fa'amalama i se vevela fa'apitoa, i luga a'e lea e tupu ai le fa'aleagaina.O le mautu o le vevela e faʻalagolago i mea e pei o le DS, susu mea, ma le iai o mea faʻaopoopo.
Nofoaga fa'aoga
Pharmaceuticals: HPMC o loʻo faʻaaogaina lautele i vailaʻau faʻapitoa e pei o mafiafia, faʻamau, mea e fai ata tifaga ma matrices faʻasaʻo.E fa'aleleia ai le fa'amavaeina o laulau, fa'amavae ma le bioavailability.
Mea'ai: I totonu o pisinisi taumafa, o lo'o fa'aogaina le HPMC e fai ma mea mafiafia, fa'amautu, emulsifier ma fa'atumu oloa e pei o sosi, la'ei, tao tao ma oloa susu.
Fausiaina: Ua fa'aopoopoina le HPMC i sima fa'avae sima, stucco ma tile fa'apipi'i e fa'aleleia atili ai galuega, fa'amauina o le vai ma le pipii.E faʻaleleia ai le faʻatinoina o nei mea faufale i tulaga eseese.
Mea teuteu: O le HPMC o loʻo faʻaaogaina e avea o se mafiafia, emulsifier ma faʻamautu i mea teuteu e pei o kulimi, lotions ma gels.E tuʻuina atu mea manaʻomia rheological ma faʻaleleia le mautu o oloa.
O le Hydroxypropyl methylcellulose (HPMC) o se fa'aputuga fa'aopoopo e fa'apipi'iina mai le cellulose e ala i le methylation ma le hydroxypropylation.O lona fausaga vaila'au, meatotino ma fa'aoga ua avea ai ma mea taua i alamanuia e pei o vaila'au, mea'ai, faufale ma mea teuteu.O isi su'esu'ega ma atina'e o tekonolosi HPMC o lo'o fa'aauau pea ona fa'alauteleina ana fa'aoga talafeagai ma fa'aleleia lona fa'atinoga i le tele o fa'atulagaga.
Taimi meli: Feb-20-2024