Hydroxypropylmethylcellulose (HPMC) wani fili ne mai amfani da shi a masana'antu daban-daban ciki har da magunguna, abinci, gini da kayan kwalliya.Fahimtar abubuwan da ke tattare da shi, tsarinsa, kaddarorinsa da aikace-aikacensa yana buƙatar zurfafa nazarin tsarin sinadarai da tsarin hada shi.
abun da ke ciki da tsari
Kashin baya na Cellulose: An samo HPMC daga cellulose, wani nau'in polymer na halitta wanda aka samo a cikin ganuwar tantanin halitta.Cellulose ya ƙunshi dogayen sarƙoƙi na raka'o'in glucose wanda aka haɗa tare da haɗin gwiwar β-1,4 glycosidic.
Methylation: Methylcellulose shine farkon zuwa HPMC kuma ana samarwa ta hanyar magance cellulose tare da alkali da methyl chloride.Tsarin ya ƙunshi maye gurbin ƙungiyoyin hydroxyl (-OH) akan kashin bayan cellulose tare da ƙungiyoyin methyl (-CH3).
Hydroxypropylation: Bayan methylation, hydroxypropylation yana faruwa.A cikin wannan mataki, propylene oxide yana amsawa tare da cellulose methylated, yana gabatar da ƙungiyoyin hydroxypropyl (-OCH2CHOHCH3) akan kashin bayan cellulose.
Matsayin Sauyawa (DS): Matsayin maye gurbin yana nufin matsakaicin adadin hydroxypropyl da methyl a kowace naúrar glucose a cikin sarkar cellulose.Wannan siga yana rinjayar kaddarorin HPMC, gami da solubility, danko, da yanayin zafi.
kira
Maganin alkaline: Ana fara bi da filaye na cellulose tare da maganin alkaline, yawanci sodium hydroxide (NaOH), don karya haɗin haɗin hydrogen na intermolecular da kuma ƙara samun dama ga ƙungiyoyin cellulose hydroxyl.
Methylation: Cellulose da aka yi da alkali yana amsawa tare da methyl chloride (CH3Cl) a ƙarƙashin yanayin sarrafawa, wanda ya haifar da maye gurbin kungiyoyin hydroxyl tare da kungiyoyin methyl.
Hydroxypropylation: Methylated cellulose ya kara amsawa tare da propylene oxide (C3H6O) a gaban mai kara kuzari kamar sodium hydroxide.Wannan halayen yana gabatar da ƙungiyoyin hydroxypropyl a cikin kashin bayan cellulose.
Neutralization da Tsarkakewa: Tsabtace cakuda amsa don cire duk wani tushe mai yawa.Samfurin da aka samu yana ɗaukar matakan tsarkakewa kamar tacewa, wankewa, da bushewa don samun samfurin HPMC na ƙarshe.
hali
Solubility: HPMC yana narkewa cikin ruwa kuma yana samar da bayani mai haske, mai danko.Solubility ya dogara da dalilai kamar digiri na maye gurbin, nauyin kwayoyin, da zafin jiki.
Dangantaka: Hanyoyin HPMC suna nuna halayen pseudoplastic, ma'ana cewa dankon su yana raguwa tare da haɓaka ƙimar ƙarfi.Ana iya sarrafa danko ta hanyar daidaita sigogi kamar DS, nauyin kwayoyin halitta da maida hankali.
Samar da Fim: HPMC tana samar da fina-finai masu sassauƙa da bayyananne lokacin da aka jefa su daga maganin ruwa.Wadannan fina-finai suna samun aikace-aikace a cikin sutura, marufi da magunguna.
Ƙarfafawar thermal: HPMC yana da kwanciyar hankali a wani yanayin zafi, sama da abin da lalacewa ke faruwa.Kwanciyar zafi ya dogara da abubuwa kamar DS, abun cikin danshi, da kasancewar abubuwan ƙari.
Yankunan aikace-aikace
Pharmaceuticals: HPMC ana amfani dashi sosai a cikin ƙirar magunguna azaman masu kauri, masu ɗaure, wakilai masu ƙirƙirar fim da matrices masu dorewa.Yana inganta tarwatsewar kwamfutar hannu, rushewa da kuma bioavailability.
Abinci: A cikin masana'antar abinci, ana amfani da HPMC azaman mai kauri, stabilizer, emulsifier da filler a cikin samfura kamar miya, riguna, kayan gasa da kayan kiwo.
Gina: Ana ƙara HPMC zuwa turmi-tushen siminti, stucco da tile adhesives don inganta aikin aiki, riƙe ruwa da mannewa.Yana inganta aikin waɗannan kayan gini a cikin yanayi daban-daban.
Kayan shafawa: Ana amfani da HPMC azaman mai kauri, emulsifier da stabilizer a cikin kayan kwalliya kamar creams, lotions da gels.Yana ba da kyawawan kaddarorin rheological kuma yana haɓaka kwanciyar hankali samfurin.
Hydroxypropyl methylcellulose (HPMC) wani fili ne na multifunctional wanda aka haɗa daga cellulose ta hanyar methylation da hanyoyin hydroxypropylation.Tsarin sinadarai, kaddarorinsa da aikace-aikace sun sa ya zama wani abu mai mahimmanci a cikin masana'antu daban-daban kamar magunguna, abinci, gini da kayan kwalliya.Ci gaba da bincike da haɓaka fasahar HPMC na ci gaba da faɗaɗa yuwuwar aikace-aikacenta da haɓaka aikinta a cikin nau'ikan ƙira.
Lokacin aikawa: Fabrairu-20-2024