Hydroxypropyl methyl cellulose HPMC ke mofuta oa non-ionic cellulose motsoako oa ether, e fapaneng le ionic methyl carboxymethyl cellulose e tsoakiloeng ether, 'me ha e sebetse ka litšepe tse boima.Ka lebaka la likarohano tse fapaneng tsa methoxyl content le hydroxypropyl content ho hydroxypropyl methylcellulose le viscosities tse fapaneng, e fetohile mefuta e fapaneng ea mefuta e nang le thepa e fapaneng, mohlala, litaba tse phahameng tsa methoxyl le litaba tse tlase tsa hydroxypropyl Ts'ebetso ea eona e haufi le ea methyl cellulose, le mefuta e nang le dikahare tse tlase tsa methoxyl le dikahare tse phahameng tsa hydroxypropyl, tshebetso ya yona e haufi le ya hydroxypropyl methylcellulose.Leha ho le joalo, ka mefuta e sa tšoaneng, le hoja ho na le palo e nyenyane feela ea sehlopha sa hydroxypropyl kapa sehlopha se senyenyane sa methoxy, ho qhibiliha ha metsoako ea lintho tse phelang kapa mocheso oa flocculation ka tharollo ea metsi e fapane haholo.
1. Ho qhibiliha ha hydroxypropyl methylcellulose
①Solubility ea hydroxypropyl methyl cellulose metsing Hydroxypropyl methyl cellulose ha e le hantle ke methyl cellulose e fetotsoeng ke propylene oxide (methyl oxypropylene), kahoo e ntse e na le thepa e tšoanang le ea methyl cellulose.Cellulose e ts'oana le ho qhibiliha ha metsi a batang le ho se qhibilihe ha metsi a chesang.Leha ho le joalo, ka lebaka la sehlopha se fetotsoeng sa hydroxypropyl, mocheso oa eona oa gelation metsing a chesang o phahame haholo ho feta oa methyl cellulose.Mohlala, viscosity ea tharollo ea metsi ea hydroxypropyl methylcellulose e nang le 2% methoxyl content DS=0.73 le hydroxypropyl content MS=0.46 ke 500 mpa?s ho 20°C.Thempereichara ea eona ea gel E ka fihla haufi le 100°C, ha methylcellulose mochesong o tšoanang e ka ba 55°C feela.Ha e le ho qhibiliha ha eona metsing, le eona e ntlafalitsoe haholo.Ka mohlala, pulverized hydroxypropyl methylcellulose (sebopeho sa granular sa 0.2 ~ 0.5mm ka 20 ° C se nang le viscosity ea 4% ea metsi a metsi ho fihlela ho 2pa?s e ka sebelisoa Mocheso oa kamore, e qhibiliha habonolo metsing ntle le ho tsidifala.
②The solubility ea hydroxypropyl methyl cellulose in organic solvents Ho qhibiliha ha hydroxypropyl methyl cellulose ka har'a metsoako ea lintho tse phelang ho boetse ho molemo ho feta ea methyl cellulose, 'me methyl cellulose e hloka ho ba le tekanyo ea ho kenya methoxyl ho Lihlahisoa tse ka holimo ho 2.1, le high-viscosity e nang le methylcellulose hydroxypropyl MS=1.5 ~ 1.8 le methoxy DS=0.2 ~ 1.0, 'me kakaretso ea tekanyo ea substitution e ka holimo ho 1.8 e qhibiliha ka methanol ea anhydrous le tharollo ea ethanol bohareng, thermoplastic le metsi.E boetse e qhibiliha ka har'a li-hydrocarbon tse chlorine joalo ka dichloromethane le chloroform, le ka har'a metsoako ea tlhaho e kang acetone, isopropanol le joala ba diacetone.Ho qhibiliha ha eona ka har'a metsoako ea tlhaho ho molemo ho feta ho qhibiliha ha metsi.
2. Lintho tse amang viscosity ea hydroxypropyl methylcellulose
Lintlha tse susumetsang tsa hydroxypropyl methyl cellulose viscosity Qeto e tloaelehileng ea viscosity ea hydroxypropyl methyl cellulose, joalo ka li-cellulose ethers tse ling, e ipapisitse le tharollo ea 2% ea metsi ho 20°C.Viscosity ea sehlahisoa se tšoanang e eketseha ka keketseho ea mahloriso.Bakeng sa lihlahisoa tse nang le boima bo fapaneng ba limolek'hule sebakeng se le seng, lihlahisoa tse nang le boima bo boholo ba limolek'hule li na le viscosity e phahameng.Kamano ea eona le mocheso e tšoana le ea methyl cellulose.Ha mocheso o ntse o eketseha, viscosity e qala ho fokotseha, empa ha e fihla mocheso o itseng, viscosity e eketseha ka tšohanyetso 'me gelation e etsahala.Mocheso oa gel oa lihlahisoa tse tlaase-viscosity o phahame.e phahame.Sebaka sa eona sa gel ha se amane feela le viscosity ea ether, empa hape le karo-karolelano ea methoxy le hydroxypropyl ka ether le tekanyo eohle ea ho fetola.Hoa lokela ho hlokomeloa hore hydroxypropyl methylcellulose le eona ke pseudoplastic mme tharollo ea eona e tsitsitse mocheso oa kamore ntle le ho senyeha ha viscosity ntle le monyetla oa ho senyeha ha enzymatic.
3. Hydroxypropyl methylcellulose acid le ho hanyetsa alkali
Hydroxypropyl methylcellulose acid le alkali resistance Hydroxypropyl methylcellulose ka kakaretso e tsitsitse ho acid le alkali, mme ha e amehe ka har'a mofuta oa pH 2 ~ 12.E khona ho mamella tekanyo e itseng ea asiti e khanyang.Tse kang formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, joalo-joalo Leha ho le joalo, acid e concentrated e na le phello ea ho fokotsa viscosity.Alkali e kang caustic soda, potash ea caustic le metsi a lime ha e na phello ho eona, empa e ka eketsa hanyenyane viscosity ea tharollo, 'me joale ho tla ba le ketsahalo ea ho fokotseha butle nakong e tlang.
4. Ho kopanya ha hydroxypropyl methylcellulose
Miscibility ea Hydroxypropyl Methyl Cellulose Hydroxypropyl methyl cellulose tharollo e ka kopanngoa le motsoako oa polymer o qhibilihang ka metsi hore e be tharollo e tšoanang le e hlakileng e nang le viscosity e phahameng.Metsoako ena ea polymer e kenyelletsa polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose le methyl cellulose.Metsoako ea tlhaho ea polymer e kang gum arabic, gum ea linaoa tsa litsie, karaya gum, joalo-joalo le eona e na le motsoako o motle le tharollo ea eona.Hydroxypropyl methylcellulose e ka boela ea tsoakoa le mannitol kapa sorbitol esters ea stearic acid kapa palmitic acid, hape e ka kopanngoa le glycerin, sorbitol le mannitol.Metsoako ena e ka sebelisoa e le hydroxypropyl methylcellulose.Plastiki e entsoeng ka cellulose.
5. Ho se kopane le ho qhibiliha ha metsi ka hydroxypropyl methylcellulose
Li-insolubilized water-soluble cellulose ethers tsa hydroxypropyl methylcellulose li ka kopanngoa le aldehyde, 'me li-ether tsena tse qhibilihang ka metsing li tšeloa ka har'a tharollo 'me li fetoha tse sa qhibiliheng metsing.Li-aldehyde tse etsang hore hydroxypropyl methylcellulose e se ke ea qhibiliha li kenyelletsa formaldehyde, glyoxal, succinaldehyde, adipaldehyde, joalo-joalo Ha u sebelisa formaldehyde, tlhokomelo e khethehileng e lokela ho lefshoa ho boleng ba pH ba tharollo, eo glyoxal e arabelang ka potlako.Ka hona, glyoxal hangata e sebelisoa e le ntho e kopanyang tlhahiso ea indasteri.Tekanyetso ea mofuta ona oa motsoako oa crosslinking ka tharollo ke 0.2% ~ 10% ea boima ba ether, ka ho khetheha 7% ~ 10%, le 3.3% ~ 6% ke eona e loketseng ka ho fetisisa bakeng sa glyoxal.Kakaretso ea mocheso oa phekolo ke 0 ~ 30 ℃, 'me nako ke 1 ~ 120min.Karabelo ea li-cross-linking e lokela ho etsoa tlas'a maemo a acidic.Ka kakaretso, asiti e matla ea inorganic kapa organic carboxylic acid e eketsoa tharollong ho lokisa pH ea tharollo hore e ka ba 2 ~ 6, haholo-holo pakeng tsa 4 ~ 6, ebe li-aldehydes li eketsoa ho phethahatsa karabelo e kopanyang..Li-acid tse sebelisoang li kenyelletsa hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid kapa citric acid, eo har'a eona formic acid kapa acetic acid e loketseng, le formic acid ke eona e nepahetseng ka ho fetisisa.Asiti le aldehyde le tsona li ka eketsoa ka nako e le 'ngoe ho lumella tharollo hore e kopane ka har'a mofuta o lakatsehang oa pH.Hangata karabelo ena e sebelisoa ts'ebetsong ea ho qetela ea phekolo nakong ea ho lokisoa ha cellulose ethers.Ka mor'a hore cellulose ether e se ke ea qhibiliha, ho loketse ho hlatsoa le ho hloekisa ka metsi ka 20 ~ 25 ° C.Ha sehlahisoa se sebelisoa, ntho ea alkaline e ka kenyelletsoa tharollo ea sehlahisoa ho lokisa pH ea tharollo hore e be alkaline, 'me sehlahisoa se tla qhibiliha ka tharollo kapele.Mokhoa ona o boetse o sebetsa ho tharollo ea cellulose ether e entsoeng ka filimi ebe filimi e sebetsoa ho e etsa filimi e sa tsitsang.
6. Hydroxypropyl methylcellulose e hanyetsana le li-enzyme
Hydroxypropyl methylcellulose e hanana le li-enzyme.Ka khopolo, li-derivatives tsa cellulose, tse kang sehlopha se seng le se seng sa anhydroglucose, li na le sehlopha se nkang sebaka se tiileng, seo ho seng bonolo ho se tšoaetsoa ke likokoana-hloko, empa ha e le hantle sehlahisoa se phethiloeng Ha boleng ba phapanyetso bo feta 1, bo tla boela bo fokotsoe ke li-enzyme. ho bolelang hore tekanyo ea ho kenya sebaka sa sehlopha se seng le se seng sa ketane ea cellulose ha e tšoane ka ho lekaneng, 'me likokoana-hloko li ka senyeha haufi le lihlopha tsa anhydroglucose tse sa nkeloang sebaka ho etsa tsoekere., tse monngoang e le limatlafatsi bakeng sa likokoana-hloko.Ka hona, haeba tekanyo ea etherification substitution ea selulose e eketseha, khanyetso ea khoholeho ea enzymatic ea cellulose ether e boetse ea ntlafatsoa.Ho tlalehoa hore viscosity e setseng ea hydroxypropyl methylcellulose (DS = 1.9) ke 13.2%, methylcellulose (DS = 1.83) ke 7.3%, le methylcellulose (DS = 1.66) ke 3.8%, 'me hydroxyethyl cellulose ke 1.7%.Ho ka bonoa hore bokhoni ba anti-enzyme ba hydroxypropyl methylcellulose bo matla.Ka hona, khanyetso e ntle ea enzyme ea hydroxypropyl methylcellulose, e kopantsoeng le thepa ea eona e ntle ea ho qhalana, e teteaneng le ea ho etsa filimi, ka kakaretso e sebelisoa ka liaparo tsa emulsion ea metsi, joalo-joalo, 'me ka kakaretso ha e hloke ho eketsoa ha li-preservatives.Leha ho le joalo, bakeng sa polokelo ea nako e telele ea tharollo kapa tšilafalo e ka khonehang ea lefats'e le ka ntle, li-preservatives li ka eketsoa e le tšireletso, 'me khetho e ka khethoa ho ea ka litlhoko tsa ho qetela tsa tharollo.Phenylmercuric acetate le manganese fluorosilicate ke li-preservatives tse sebetsang hantle, empa li na le Toxicity ka bobeli, tlhokomelo e tlameha ho lefshoa ts'ebetsong, 'me tekanyo e tloaelehileng ke 1 ~ 5mg ea phenylmercuric acetate ka litha e le nngwe ea tharollo.
7. Thepa ea filimi ea hydroxypropyl methylcellulose
Ts'ebetso ea filimi ea hydroxypropyl methylcellulose Hydroxypropyl methylcellulose e na le thepa e ntle haholo ea ho etsa filimi, 'me tharollo ea eona e nang le metsi kapa tharollo ea mokelikeli oa lintho tse phelang e koahetsoe holim'a poleiti ea khalase,' me e fetoha e se nang mebala le e hlakileng ka mor'a ho omisa.Le filimi e thata.E na le khanyetso e ntle ea mongobo 'me e lula e tiile mocheso o phahameng.Ka mohlala, ho kenya polasetiki ea hygroscopic ho ka ntlafatsa bolelele le ho tenyetseha ha eona.Ho ntlafatsa ho feto-fetoha ha maemo, li-plasticizers tse kang glycerin le sorbitol ke tsona tse loketseng ka ho fetisisa.Tharollo e akaretsang ke 2% ~ 3%, 'me palo ea plasticizer ke 10% ~ 20% ea cellulose ether.Haeba litaba tsa plasticizer li phahame haholo, ts'ebetso ea shrinkage ea colloid dehydration e tla etsahala tlas'a mongobo o phahameng.Matla a thata a filimi e nang le polasetiki e kenyelletsoeng e kholoanyane ho feta e se nang polasetiki, 'me e eketseha ka keketseho ea palo e eketsehileng.Ha e le hygroscopicity ea filimi, e boetse e eketseha ka keketseho ea palo ea plasticizer.
Nako ea poso: Oct-13-2022