Hydroxypropyl methyl cellulose HPMC o se ituaiga e le ionic cellulose fefiloi eter, lea e ese mai ionic methyl carboxymethyl cellulose fefiloi eter, ma e le tali atu i metals mamafa.Ona o le eseesega o fua faatatau o le methoxyl anotusi ma le hydroxypropyl anotusi i le hydroxypropyl methylcellulose ma viscosities eseese, ua avea ma ituaiga eseese ma meatotino eseese, mo se faataitaiga, maualuga methoxyl anotusi ma maualalo hydroxypropyl anotusi O lona faatinoga e latalata i le methyl cellulose, ma o ituaiga e maualalo le methoxyl content ma maualuga hydroxypropyl content, o lona faʻatinoga e latalata ile hydroxypropyl methylcellulose.Ae ui i lea, i ituaiga eseese, e ui lava na o sina vaega itiiti o le hydroxypropyl group poʻo se vaega itiiti o le methoxy group o loʻo i ai, o le solubility i solvents organic poʻo le vevela o le flocculation i le vai vaifofo e matua ese lava.
1. Le solubility o le hydroxypropyl methylcellulose
①Solubility o le hydroxypropyl methyl cellulose i totonu o le vai Hydroxypropyl methyl cellulose o le mea moni o se methyl cellulose ua suia e propylene oxide (methyl oxypropylene), o lea o loʻo i ai pea mea tutusa ma le methyl cellulose.E tutusa le cellulose i le vai malulu ma le vai vevela.Ae ui i lea, ona o le suiga o le hydroxypropyl vaega, o lona vevela gelation i le vai vevela e sili atu le maualuga nai lo le methyl cellulose.Mo se fa'ata'ita'iga, o le viscosity o le vaifofo vai o le hydroxypropyl methylcellulose ma le 2% methoxyl content DS=0.73 ma le hydroxypropyl content MS=0.46 e 500 mpa?s ile 20°C.O lona vevela gel E mafai ona oʻo atu i le 100 ° C, ae o le methylcellulose i le vevela tutusa e naʻo le 55 ° C.Ae mo lona soluble i le vai, ua matua faaleleia foi.Mo se faʻataʻitaʻiga, o le pulverized hydroxypropyl methylcellulose (foliga faʻapitoa o le 0.2 ~ 0.5mm i le 20 ° C ma le viscosity o le 4% vaifofo vai e oʻo atu i le 2pa?s e mafai ona faʻaaogaina i I le vevela o le potu, e faigofie ona solu i totonu o le vai e aunoa ma le malulu.
②O le solubility o le hydroxypropyl methyl cellulose i solvents organic O le solubility o le hydroxypropyl methyl cellulose i solvents organic e sili atu foi nai lo le methyl cellulose, ma e manaʻomia e le methyl cellulose se tikeri o le suitulaga methoxyl i oloa i luga aʻe o le 2.1, ma le maualuga-viscosity hydroxypropyl o loʻo i ai le methylcellulose. hydroxypropyl MS = 1.5 ~ 1.8 ma methoxy DS = 0.2 ~ 1.0, ma le aofaʻi o le tikeri sui i luga aʻe o le 1.8 e mafai ona soluble i le anhydrous methanol ma le ethanol solutions medium, thermoplastic ma vai-soluble.E mafai foi ona solu i totonu o le chlorinated hydrocarbons e pei o le dichloromethane ma le chloroform, ma i totonu o solvents organic pei ole acetone, isopropanol ma le diacetone alcohol.E sili atu lona solubility i soluble organic nai lo vai soluble.
2. O mea e aafia ai le viscosity o le hydroxypropyl methylcellulose
O a'afiaga o le hydroxypropyl methyl cellulose viscosity O le fuaina o le viscosity masani o le hydroxypropyl methyl cellulose, e pei o isi cellulose ethers, e fa'avae i luga o se vaifofo 2% i le 20°C.O le viscosity o le oloa lava e tasi e faateleina i le faateleina o le faʻatonuga.Mo oloa e eseese mamafa mole mole i le faʻatonuga tutusa, o oloa e tele mole mamafa mamafa e maualuga atu le viscosity.O lona sootaga ma le vevela e tutusa ma le methyl cellulose.A faʻatuputeleina le vevela, e amata ona faʻaitiitia le viscosity, ae a oʻo i se vevela, faʻafuaseʻi ona faʻateleina le viscosity ma tupu ai le gelation.O le vevela gel o oloa maualalo-viscosity e maualuga atu.e maualuga.O lona tulaga gel e le gata e fesoʻotaʻi ma le viscosity o le ether, ae faʻapea foʻi i le fua faatatau o le methoxy ma le hydroxypropyl i le ether ma le tikeri atoa o le sui.E tatau ona maitauina o le hydroxypropyl methylcellulose o le pseudoplastic foi ma o lona fofo e mautu i le vevela o le potu e aunoa ma se faʻaleagaina o le viscosity sei vagana ai le avanoa e faʻaleagaina ai le enzymatic.
3. Hydroxypropyl methylcellulose acid ma alkali tetee
Hydroxypropyl methylcellulose acid ma alkali tetee Hydroxypropyl methylcellulose e masani ona mautu i acid ma alkali, ma e le aafia i le tele o pH 2 ~ 12.E mafai ona tatalia se aofaiga patino o le ga'o mama.E pei ole formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, ma isi.Alkali e pei o le soda, caustic potash ma le lime vai e leai se aoga i ai, ae mafai ona faʻatupulaʻia teisi le viscosity o le vaifofo, ona i ai lea o se faʻalavelave faʻagesegese i le lumanaʻi.
4. Fa'afefiloi ole hydroxypropyl methylcellulose
Fa'aliga ole Hydroxypropyl Methyl Cellulose Hydroxypropyl methyl cellulose solution e mafai ona fa'afefiloi ma le vai-soluble polymer compound e avea ma se vaifofo toniga ma manino ma maualuga le viscosity.O nei polymer compound e aofia ai le polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose ma le methyl cellulose.O mea fa'alenatura polymer e pei o le gum arabic, locust bean gum, karaya gum, ma isi mea e lelei foi le fa'afefiloi ma lona fofo.Hydroxypropyl methylcellulose e mafai foi ona faʻafefiloi ma le mannitol poʻo le sorbitol esters o le stearic acid poʻo le palmitic acid, ma e mafai foi ona faʻafefiloi ma le glycerin, sorbitol ma le mannitol.E mafai ona faʻaaogaina nei mea faʻapitoa e pei o le hydroxypropyl methylcellulose.Fa'apipi'i fa'apipi'i fa'aselulosa.
5. Le mafai ona solu ma vai solubility o le hydroxypropyl methylcellulose
Ole eter ole cellulose ole vai ole hydroxypropyl methylcellulose e mafai ona feso'ota'i i luga ole laiga ma aldehydes, ma o nei eter ole vai e fa'afefeteina i le vaifofo ma e le mafai ona solu ile vai.O aldehydes e faʻaaogaina ai le hydroxypropyl methylcellulose e le mafai ona faʻaaogaina e aofia ai formaldehyde, glyoxal, succinaldehyde, adipaldehyde, ma isi. Pe a faʻaaogaina formaldehyde, e tatau ona totogia faʻapitoa le tau o le pH o le vaifofo, e aofia ai le glyoxal vave tali atu.O le mea lea, o le glyoxal e masani ona faʻaaogaina e fai ma sui faʻafesoʻotaʻi i le gaosiga o pisinisi.O le fua o lenei ituaiga o sui sooupu crosslinking i le fofo o le 0.2% ~ 10% o le ether tele, sili 7% ~ 10%, ma 3.3% ~ 6% e sili ona talafeagai mo glyoxal.Ole vevela ole togafitiga masani ole 0 ~ 30℃, ma ole taimi ole 1~120min.E mana'omia le fa'atinoina o le fa'agasologa o feso'ota'iga i lalo ole tulaga oona.E masani lava, e faʻaopoopoina le vailaʻau malosi poʻo le carboxylic acid i le vaifofo e faʻafetaui ai le pH o le vaifofo i le 2 ~ 6, sili i le va o le 4 ~ 6, ona faʻaopoopoina lea o aldehydes e faʻatino ai le fesoʻotaʻiga fesoʻotaʻiga..O vailaʻau o loʻo faʻaaogaina e aofia ai le hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid poʻo le citric acid, e aofia ai le formic acid poʻo le acetic acid e talafeagai, ma le formic acid e sili ona lelei.O le acid ma le aldehyde e mafai foi ona faʻaopoopoina i le taimi e tasi e faʻataga ai le vaifofo e faʻafesoʻotaʻi i le pH manaʻomia.O lenei tali e masani ona faʻaaogaina i le faʻagasologa o togafitiga mulimuli i le sauniuniga o le cellulose ethers.A maeʻa ona faʻafefeteina le cellulose ether, e faigofie ona fufulu ma faʻamamaina i le vai ile 20 ~ 25 ° C.A faʻaaogaina le oloa, e mafai ona faʻaopopo se mea alkaline i le vaifofo o le oloa e faʻafetaui ai le pH o le vaifofo e avea ma alkaline, ma o le a faʻaumatia vave le oloa i le fofo.O lenei metotia e faʻaoga foi i le cellulose ether solution e faia i totonu o se ata tifaga ona faʻaogaina lea o le ata e avea ma ata e le mafai ona faʻaaogaina.
6. Hydroxypropyl methylcellulose e tetee i enzymes
Hydroxypropyl methylcellulose e tetee i enzymes.I le talitonuga, o mea e maua mai i le cellulose, e pei o vaega taʻitasi o le anhydroglucose, o loʻo i ai se vaega faʻapipiʻi faʻamautu, e le faigofie ona aʻafia e microorganisms, ae o le mea moni o le oloa maeʻa Pe a sili atu le tau suitulaga i le 1, o le a faʻaleagaina foi e enzymes, o lona uiga o le tikeri o le suitulaga o vaega taitasi i luga o le filifili cellulose e le o tutusa lelei, ma microorganisms e mafai ona tafi latalata i le le suia o vaega anhydroglucose e fausia ai suka., lea e mitiia e avea ma meaʻai mo microorganisms.O le mea lea, afai o le etherification suitulaga tikeri o le cellulose faateleina, o le tetee i enzymatic erosion o cellulose eter e faaleleia foi.Ua lipotia mai o le viscosity totoe o le hydroxypropyl methylcellulose (DS = 1.9) o le 13.2%, methylcellulose (DS = 1.83) o le 7.3%, ma le methylcellulose (DS = 1.66) o le 3.8%, ma le hydroxyethyl cellulose o le 1.7%.E mafai ona iloa o le malosi o le anti-enzyme o le hydroxypropyl methylcellulose e malosi.O le mea lea, o le sili atu o le enzyme teteʻe o le hydroxypropyl methylcellulose, faʻatasi ma lona faʻasalalau lelei, mafiafia ma ata tifaga, e masani ona faʻaaogaina i vai-emulsion coatings, ma isi, ma e masani lava e le manaʻomia le faʻaopoopoga o mea faʻasao.Ae ui i lea, mo le teuina umi o le fofo poʻo le faʻaleagaina o le lalolagi i fafo, e mafai ona faʻapipiʻi mea faʻasao e fai ma puipuiga, ma e mafai ona fuafua le filifiliga e tusa ai ma manaoga mulimuli o le fofo.Phenylmercuric acetate ma manganese fluorosilicate o ni puipuiga lelei, ae o loʻo i ai uma le Toxicity, e tatau ona gauai atu i le taotoga, ma o le fua e masani lava 1 ~ 5mg o le phenylmercuric acetate i le lita o le vaifofo.
7. Meatotino o ata tifaga hydroxypropyl methylcellulose
O le faatinoga o le hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose o loʻo i ai ni mea e sili ona lelei e fai ai ata, ma o lona vaifofo vai poʻo le vaifofo faʻamaʻi e ufiufi i luga o se ipu tioata, ma e le lanu ma manino pe a uma ona faʻamago.Ma ata tifaga faigata.E lelei le susū e tete'e ma tumau mausali i le vevela maualuga.Mo se faʻataʻitaʻiga, faʻaopoopoina se plasticizer hygroscopic e mafai ona faʻaleleia lona faʻalauteleina ma le fetuutuunai.Ina ia faʻaleleia le fetuutuunai, o mea faʻapipiʻi e pei o le glycerin ma le sorbitol e sili ona talafeagai.Ole faʻatonuga lautele ole fofo ole 2% ~ 3%, ma le aofaʻi o le plasticizer o le 10% ~ 20% o le cellulose ether.Afai e maualuga tele le mea o loʻo i totonu o le plasticizer, o le faʻaitiitia o le faʻamaʻi o le colloid o le a tupu i lalo o le maualuga o le susu.O le malosi faʻamalosi o le ata faʻatasi ma le plasticizer faaopoopo e sili atu le tele nai lo le leai o se plasticizer, ma faʻateleina i le faʻaopoopoga o le aofaʻi faaopoopo.Ae mo le hygroscopicity o le ata, e faʻateleina foi i le faʻaopoopoga o le aofaʻi o le plasticizer.
Taimi meli: Oke-13-2022